| 研究課題/領域番号 |
22K14742
|
|---|
| 研究種目 |
若手研究
|
| 配分区分 | 基金 |
|---|
| 審査区分 |
小区分35030:有機機能材料関連
|
|---|
| 研究機関 | 長崎大学 |
|---|
研究代表者 |
|
|---|
| 研究期間 (年度) |
2022-04-01 – 2026-03-31
|
| 研究課題ステータス |
交付 (2023年度)
|
| 配分額 *注記 |
4,160千円 (直接経費: 3,200千円、間接経費: 960千円)
2025年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
2024年度: 910千円 (直接経費: 700千円、間接経費: 210千円)
2023年度: 520千円 (直接経費: 400千円、間接経費: 120千円)
2022年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
|
|---|
| キーワード | cancer therapy / noble metal / prodrug / templated crystallize / nanomedicine / nanodrugs / metallic cluster / reprecipitation / crystallization |
|---|
| 研究開始時の研究の概要 |
The research proposal aims to be the first establishment of hybrid prodrug nanocrystals with morphology controlled by templated crystallization in the presence of noble metallic nanoparticles, to achieve self-delivery and on-demand drug release.
The obtained hybrid prodrug nanoparticles (NPs) are expected to: (i) Advance the traditional prodrug NPs to a multifunctional system with controllable drug release and designable targeting; and (ii) Provide a facile protocol to fabricate hybrid nanomaterials that size, shape, composition, and properties can be tuned.
|
| 研究実績の概要 |
The purpose of this research is to design and fabricate a carrier-free nanodrug via templated-crystallization method using SN-38, the active metabolite of irinotecan, acts as a potent inhibitor of DNA topoisomerase I. In this work, several derivatives of SN-38 were selected as the anticancer moiety, and Au cluster of ca. 10 nm was selected as a template. The nanodrugs are fabricated by reprecipitation method.
The formation yield of the hybrid nanodrugs were improved by adjusting the reprecipitation conditions, such as the good solvent of Au nanoparticles. The morphology of Au/SN-38Chol nanoparticles was confirmed SEM and showed a narrow size distribution and template-guided shape. Photothermal effect was investigated and exhibited a sufficient performance in comparison to pure Au nanoparticles.
|
| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
The second targets of the research plan are close to being complete, including observation of charge transfer effect between noble metal nanoparticles and drug molecules. The research is progressing to the profiling of the drug release kinetic at different conditions.
|
| 今後の研究の推進方策 |
The next targets of the research are investigation of charge transfer effect by UV-Vis, XPS, and FT-IR. The results are correlated with the drug release rate and composition of SN-38 hybrid NPs.
|
