| 研究課題/領域番号 |
22K15121
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分44020:発生生物学関連
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| 研究機関 | 金沢大学 |
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研究代表者 |
WANG Miaoxing 金沢大学, 新学術創成研究機構, 研究協力員 (50936557)
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| 研究期間 (年度) |
2022-04-01 – 2023-03-31
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| 研究課題ステータス |
中途終了 (2022年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2023年度: 2,080千円 (直接経費: 1,600千円、間接経費: 480千円)
2022年度: 2,470千円 (直接経費: 1,900千円、間接経費: 570千円)
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| キーワード | Wnt/PCP / column formation / Wnt / PCP / neuron |
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| 研究開始時の研究の概要 |
By using fly brain as a model and focusing on the columnar structures in the brain, I will clarify the following questions:
a. How does PCP signaling regulate the polarity of neurons during column formation.
b. If and how do Wnt ligands control the PCP singling in a single cell.
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| 研究実績の概要 |
Wnt/PCP signaling is evolutionarily conserved from Drosophila to humans and is highly related to cancer and Alzheimer’s disease. Nevertheless, recent studies argue contradictory results about the roles of Wnt ligands in regulating PCP signaling. Our study utilizes an excellent model system to clarify this problem by revealing evolutionarily conserved mechanisms of column formation.
In this project, we have generated knock-in alleles to visualized subcellular distribution of PCP proteins; 2) we identified the subcellular distribution of PCP proteins in the singal core columnar neurons by combining specific neurons-FLPase strains that express FLPase specifically in core columnar neurons with the knock-in strains. These findings and results provide an important basis for our research.
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