| 研究課題/領域番号 |
22K15252
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分47010:薬系化学および創薬科学関連
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| 研究機関 | 大阪大学 |
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研究代表者 |
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| 研究期間 (年度) |
2022-04-01 – 2024-03-31
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| 研究課題ステータス |
完了 (2023年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2023年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
2022年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
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| キーワード | natural product extract / chemical diversification / metal catalyst / lead compound |
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| 研究開始時の研究の概要 |
Natural products (NPs) play invaluable roles for drug discovery and development. However, during last two decades, the de-emphasis of NP research correlated to overall reduction in new leads and drug approval. To create brand new biologically active compounds from NPs, we set up our methodology by using of diversity-oriented synthesis of NP extracts, via metal nanoparticle catalysts. This synthesis could directly access a number of NP-like compounds in one-step. Our new approach is promising for faster and more efficient drug discovery and development.
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| 研究実績の概要 |
Our recent research extends previous success in diversification of natural product extracts. We have focused on employing Palladium nanoparticle catalyst for enhanced chemical diversification. These catalyst offers efficient catalysis of C-H bond activation, C-C cleavage, and cross-coupling reactions, facilitating the creation of diverse molecular scaffolds through C-C and/or C-heteroatom bond formations, thus generating new molecular structures. Additionally, we are currently developing highly reactive Rhodium nanoparticle catalyst, which hold promise for further expanding the scope and efficacy of chemical diversification. Our research underscores the potential of nanoparticle catalysts in driving innovative and sustainable approaches, with implications for advancing the exploration and exploitation of natural product diversity for pharmaceutical applications.
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