| 研究課題/領域番号 |
22K15487
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分49070:免疫学関連
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| 研究機関 | 東京医科歯科大学 |
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研究代表者 |
スルタン ソフィア・シェリル 東京医科歯科大学, 難治疾患研究所, 非常勤講師 (20838437)
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| 研究期間 (年度) |
2022-04-01 – 2023-03-31
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| 研究課題ステータス |
中途終了 (2022年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2023年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
2022年度: 2,730千円 (直接経費: 2,100千円、間接経費: 630千円)
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| キーワード | CD72 / C1Q / SLE / CD72-C1q interaction |
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| 研究開始時の研究の概要 |
Systemic Lupus Erythematosus is a multi-faceted autoimmune disease. Our research is focused on understanding the development of this disease. We are trying to find a mechanistic explanation of the immune-modulatory role of the complement protein C1q which is strongly implicated with SLE development.
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| 研究実績の概要 |
Systemic Lupus Erythematosus is an autoimmune disease in which B cells play an integral role through autoantibody secretion. Our lab has previously provided evidence of the involvement of CD72, an inhibitory B cell receptor in SLE development. In this project, we investigated the possibility that CD72 is a receptor for C1q ( a complement protein that binds to apoptotic cells ). Invitro studies showed an interaction between CD72 and C1q. For further investigation, functional analysis was done to study if a fusion protein composed of CD72 and C1q can inhibit B cell responses to apoptotic cells. To extend the scope of the study to an in vivo level, a targeting vector expressing a fusion protein composed of the globular domain of C1q fused to the CD72 receptor was created.
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