| 研究課題/領域番号 |
22K17259
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分57070:成長および発育系歯学関連
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| 研究機関 | 北海道医療大学 |
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研究代表者 |
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| 研究期間 (年度) |
2022-04-01 – 2024-03-31
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| 研究課題ステータス |
中途終了 (2023年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2024年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
2023年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2022年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | malassez / amelogenin / minelarization / Amleogenin / Clone / Malassez |
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| 研究開始時の研究の概要 |
The importance of these three trials is that they establish a therapeutic strategy for the regeneration of the entire PDL (tissue around tooth) complex to restore the functions of the tooth. Combining these three phases could help develop a therapeutic strategy for the regeneration of hard tissue or PDL tissue, from basic research to clinical application.
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| 研究実績の概要 |
In this study, we planned to isolate ERM from mice, but since it was difficult to isolate, we used amelogenin (Emdogain) extracted from pig tooth germ.
In my previous research, I reported that Amelogenin derived from porcine ERM plays a role in inhibiting the calcification of root and alveolar bone. However, it was also shown that amelogenin promotes the calcification of hydroxyapatite in enamel. This implies that the role of Amelogenin may differ based on where and when it is expressed in vivo.
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