| 研究課題/領域番号 |
22K17352
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分58020:衛生学および公衆衛生学分野関連:実験系を含む
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| 研究機関 | 大阪公立大学 |
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研究代表者 |
チバング・カバンバ エバリステ 大阪公立大学, 大学院医学研究科, 特任助教 (50900693)
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| 研究期間 (年度) |
2022-04-01 – 2024-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2023年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2022年度: 3,250千円 (直接経費: 2,500千円、間接経費: 750千円)
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| キーワード | SARS-CoV-2 / Virus / Congo / Sequencing / Genome / Mbujimayi / Laboratory |
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| 研究開始時の研究の概要 |
The outline of research is to provide a diagnostic and surveillance tool that enable generating actionable information on which to implement targeted public health strategy that will facilitate greater and early anticipation as well as initiation of effective strategies to mitigate and contain outbreaks of SARS-CoV-2 variants and other viruses.
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| 研究実績の概要 |
In the FY2022, we developed the portable viral surveillance toolkit and obtained various research authorizations. Therefore, we brought together needed equipment and reagents to set up and validate the portable toolkit fitted in a suitcase for low-cost and rapid sequencing of SARS-CoV-2 and other viruses circulating in different regions, including rural areas of the Democratic Republic of Congo (DRC). Crucial steps were taken to obtain research agreements including collaboration and material transfer agreements between Japanese and Congolese universities as well as the ABS permit by Congolese Officials. Finally, research protocols for field studies were drafted and submitted for approval to the National Ethics Committee of the Ministry of Health in the DRC.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The project experienced slight delays in receiving reagents ordered from outside of Japan, as well as in administrative procedures for obtaining authorizations from Congolese officials. Restrictions related to the COVID-19 pandemic situation also played some role in slowing activities. However, at this stage, the progress made is encouraging and suggests that the projects can be completed within the timeframe set by the grant.
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| 今後の研究の推進方策 |
The next phase of this project consists of the field deployment of the viral surveillance toolkit to conduct molecular surveys in rural DRC from July to September 2023. These surveys will sequence viruses possibly circulating among Congolese people and will also investigate the potential mother-to-child transmission of different viruses. In subjects positive for specific viruses such as SARS-CoV-2, Mpox, and hepatitis B virus, additional analyzes will be carried out to characterize the viral variants involved. Outcomes obtained will be discussed with local health-decision makers for early response to endemic viral infections and will be published as scientific articles in international journals.
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