| 研究課題/領域番号 |
22K18165
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分90110:生体医工学関連
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| 研究機関 | 北海道大学 |
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研究代表者 |
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| 研究期間 (年度) |
2022-04-01 – 2024-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2023年度: 2,080千円 (直接経費: 1,600千円、間接経費: 480千円)
2022年度: 2,470千円 (直接経費: 1,900千円、間接経費: 570千円)
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| キーワード | Mechanical stress / Microtubule / Motor Protein / in vitro / MD simulation |
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| 研究開始時の研究の概要 |
Microtubules (MTs) have recently gained attention as mechanosensors. Based on the finding that mechanically deformed MTs alter kinesin transport dynamics, I hypothesize that MTs are mechanotransducers. The present study will utilize the recently developed "micro stretcher" that applies mechanical stress on MTs in vitro and supports simultaneous fluorescence imaging to address issues like how mechanical stress-induced deformation of MT affect motor protein transport dynamics, if the dynamics are restored upon withdrawing stress and its theoretical basis from molecular dynamics simulation.
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