| 研究課題/領域番号 |
22K18182
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分90110:生体医工学関連
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| 研究機関 | 東京大学 |
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研究代表者 |
DANOY MATHIEU 東京大学, 大学院工学系研究科(工学部), 助教 (90882621)
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| 研究期間 (年度) |
2022-04-01 – 2023-03-31
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| 研究課題ステータス |
中途終了 (2022年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2024年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
2023年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
2022年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
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| キーワード | Tumor / Pancreas / Liver / hiPSCs / Stroma / Fibroblasts / Macrophages / Cancer / PDAC / Metastasis / Pathophysiology |
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| 研究開始時の研究の概要 |
A coculture model of hepatic and pancreatic ductal adenocarcinoma cells will be designed to mimic the development of metastasis of the latter within the liver. The model will aim at reproducing accurately the cellular environment while being compatible with clinical drug screening.
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| 研究実績の概要 |
The differentiation of hiPSCs-derived tumor models has been achieved with several cell lines. Depending on the cancer cell line used for the induction, the models were found to express markers typical of cancer stem cells, tumor-associated macrophages, and cancer-associated fibroblasts. The function has also been tested for those cell types in terms of proteins such as Ki67. The different models have been sorted to investigate the percentage in each cell type of each model. The project has been prematurely ended due to a change of employment of the principal investigator.
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