| 研究課題/領域番号 |
22K18200
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分90120:生体材料学関連
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
Han Aifang 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 (30938832)
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| 研究期間 (年度) |
2022-04-01 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2023年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円)
2022年度: 2,730千円 (直接経費: 2,100千円、間接経費: 630千円)
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| キーワード | micro-casting / cell morphogenesis / extracellular matrix / biomaterial / surface mobility |
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| 研究開始時の研究の概要 |
The applicant has been designed a unique substrate. The substrate is different in surface molecular mobility relying on the stripe-patterned distribution. When cells sensitively recognized the mobility stripe via the integrin-extracellular matrix (ECM) attachment, the cell morphology may be affected, such as elongation. Through the observation, the applicant wants to point out the importance of the surface mobility in terms of cell morphogenesis.
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| 研究実績の概要 |
Micro-casting fabrication of multi collagen strips patterned surface has been
achieved. The addition of DMS-co-EO into Polydimethylsiloxane(PDMS) mold has improved the harvesting of collagen strips greatly. The underlying reason is due to the increased wettability of DMS-co-EO added PDMS mold compared to PDMS mold. The fibroblast cell elongation morphology has been observed onto the micro-patterned collagen strip surface.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
I take maternity leave and childcare leave during 2023.07-2024.03
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| 今後の研究の推進方策 |
I will continue to do other cell types (stem cell, muscle cell) to observe the cell morphology on the micropatterned extracellular matrix surface. Also, I will try different types of extracellular matrix (alumina, fibronectin) micropatterned on the device to detect the cell morphology.
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