| 研究課題/領域番号 |
22K18737
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| 研究種目 |
挑戦的研究(萌芽)
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| 配分区分 | 基金 |
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| 審査区分 |
中区分17:地球惑星科学およびその関連分野
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| 研究機関 | 九州大学 |
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研究代表者 |
エダラテイ カベー 九州大学, カーボンニュートラル・エネルギー国際研究所, 准教授 (60709608)
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| 研究期間 (年度) |
2022-06-30 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
6,500千円 (直接経費: 5,000千円、間接経費: 1,500千円)
2024年度: 2,080千円 (直接経費: 1,600千円、間接経費: 480千円)
2023年度: 2,210千円 (直接経費: 1,700千円、間接経費: 510千円)
2022年度: 2,210千円 (直接経費: 1,700千円、間接経費: 510千円)
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| キーワード | Origin of Life / High-Pressure Torsion / Protein / Amino Acids / RNA |
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| 研究開始時の研究の概要 |
This project challenges to shed light on the origin of life by mechanical production of protein and RNA as two essential biomolecules. Since such a mechanical production could possibly happen by meteoroid/asteroid/comet collision in the early earth conditions, the collisions are simulated by high-pressure torsion (HPT) under high pressure, high strain and high temperature. The project focuses on the processing of amino acids and adenosine monophosphate which are the building blocks of RNA and protein.
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| 研究実績の概要 |
L-glutamic acid, and L-serine, as two amino acids detected in meteorites, were further processed by high-pressure torsion (HPT) and examined by ex situ X-ray diffraction, Raman spectroscopy, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and in situ mechanical shear testing. No polymerization, chemical reactions, or phase transformations are detected after HPT, indicating that the stability and presence of these two amino acids in meteorites are quite reasonable. However, some microstructural and mechanical changes like crystal size reduction to the nanometer level, crystal defect formation, lattice expansion by vacancy formation, and shear strength enhancement to the steady state are found. HPT was also applied to adenosine monophosphate as a monomer for the formation of DNA and RNA. The material shows some structural and chemical changes that need to be examined by detailed analyses in FY2024. Such changes are more severe in the presence of water.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
we completed our detailed analysis of three main amino acids and we also could process adenosine monophosphate. It was also possible to establish a mass spectroscopy system in the laboratory which will further enhance the quality of analyses to find a piece of evidence for the formation of polymers by astronomical impacts.
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| 今後の研究の推進方策 |
The main focus in FY2024 will be on the analysis of adenosine monophosphate with different characterization methods including ex situ X-ray diffraction, Raman spectroscopy, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and in situ mechanical shear testing. Moreover, a mixture of amino acids will be subjected to high-pressure torsion to find if polymerization can occur. The effect of phosphoric acid and an oxide mineral on the behavior of amino acids will be examined as well.
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