| 研究課題/領域番号 |
22K20647
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| 研究種目 |
研究活動スタート支援
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| 配分区分 | 基金 |
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| 審査区分 |
0702:細胞レベルから個体レベルの生物学およびその関連分野
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| 研究機関 | 東北大学 |
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研究代表者 |
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| 研究期間 (年度) |
2022-08-31 – 2024-03-31
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| 研究課題ステータス |
完了 (2023年度)
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| 配分額 *注記 |
2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
2023年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2022年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | Osteocytes / Transcriptome / Proteome / Glut 1 / Diabetes / Bone / Osteokines / Skeleton / Obesity / Proteomics / Animal models / Skeletal regulation / Osteocyte / Energy metabolism / Skeletal Endocrinology |
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| 研究開始時の研究の概要 |
In this project I will define the relationship between osteocytes and glucose uptake, its mechanism, its effect on metabolic disorders, and identify osteokines as tools for early prediction of diabetes
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| 研究実績の概要 |
The purpose of this research is two-fold: 1.Evaluate the regulation of energy homeostasis by the skeleton (bone) and 2.The effect of energy perturbation on the skeleton. We developed Glut1 bone specific knockout mice to study the effect of glucose abstinence on bone structural and functional parameters. Mice body weight decreased in the knockout group which indicates that glucose metabolism by the skeleton affects whole body metabolism and bone density. Additionally transcriptome and proteome-wide analysis conducted on hyperglycemic osteocytes (bone cells) were used to constructing a molecular network to reveal a bone-specific effect of hyperglycemia across the analyzed omics levels which revealed a dissociation between transcription (gene expression) and translation (osteokine levels).
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