研究開始時の研究の概要 |
We will assess whether PilVax nasal vaccine induces antigen (M2e)-specific antibody responses in both mucosal and systemic compartments. When significant titers of M2e-specific mucosal IgA and serum IgG antibody responses are noted, we will test the functional properties of the M2e-specific antibodies by challenging vaccinated mice with influenza virus strains (H1N1, e.g., A/California and H3N2, e.g., A/Guizhou) to confirm protective immunity.
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