| 研究実績の概要 |
Fast and direct permeation of drug molecules is crucial for effective biotherapeutics. Inspired by fluorous compounds disrupting the hydrogen-bonding network of water, Abir developed CyclicFP-X, a fluoro-crown ether phosphate. It efficiently delivers bioactive cargos into cancer cells without endocytic entrapment. In contrast, nonfluorinated analogues failed to internalize, while acyclic fluorous analogues showed slow uptake via endocytic trapping. CyclicFP-X, designed to be compact and highly water soluble, disrupts lipid vesicles' hydration layers. Raman spectroscopy confirmed its -OH bonds in water. CyclicFP-X, conjugated with fluorouracil (FU), NBDHEX, and doxorubicin (DOX) as an anticancer drug, demonstrated its effectiveness as a carrier for biotherapeutics.
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