| 研究課題/領域番号 |
22KF0402
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| 補助金の研究課題番号 |
22F22077 (2022)
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 基金 (2023)
補助金 (2022) |
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| 応募区分 | 外国 |
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| 審査区分 |
小区分46010:神経科学一般関連
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| 研究分担者 |
HE HONGSHEN 国立研究開発法人理化学研究所, 脳神経科学研究センター, 外国人特別研究員
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| 研究期間 (年度) |
2023-03-08 – 2024-03-31
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| 研究課題ステータス |
完了 (2023年度)
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| 配分額 *注記 |
2,300千円 (直接経費: 2,300千円)
2023年度: 1,100千円 (直接経費: 1,100千円)
2022年度: 1,200千円 (直接経費: 1,200千円)
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| キーワード | hippocampus / CA2 / electrophysiology / SWR / behavioral state / consolidation / medial septum / spatial memory / locomotion / connectome |
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| 研究開始時の研究の概要 |
Spatial navigation critically relies on the hippocampus, a structure that functionally integrates the rate and temporal information that constitutes memory engrams. While much of the circuitry is well characterized, the role of input form the cortex to the small CA2 region remains unknown; my experiment will address the contribution of these projections to memory.
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| 研究実績の概要 |
We found that CA2 can differentially impact hippocampal network dynamics across behavioral state. During ripples silencing CA2 reduces network synchronization and weakens cross-frequency coupling and memory replay in CA1. During locomotion CA2 inhibition leads to a slower emergence of place fields and poorer lap-by-lap stability ,while during pausing periods, inhibition rsulted in reduced excitability of CA1 pyramidal cells. A novel convolutional neural network model confirmed our results on the population level, suggesting a functional role of CA2 in organizing and differentiating hippocampal network dynamics under distinct behavioral states. These results provide an overall viewpoint for novel functional roles of CA2, not only in organizing SWRs during quiet rest but also impacting learning-associated plasticity during locomotion and supporting spatial coding during awake immobility. These results have been summarized and published in Hippocampus (He et al., 2023).
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