| 研究課題/領域番号 |
22KF0418
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| 補助金の研究課題番号 |
22F22379 (2022)
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| 研究種目 |
特別研究員奨励費
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| 配分区分 | 基金 (2023)
補助金 (2022) |
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| 応募区分 | 外国 |
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| 審査区分 |
小区分45020:進化生物学関連
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| 研究機関 | 国立研究開発法人海洋研究開発機構 (2023)
国立研究開発法人産業技術総合研究所 (2022) |
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研究代表者 |
延 優 (NOBUMASARU・KONISHI) 国立研究開発法人海洋研究開発機構, 超先鋭研究開発部門(超先鋭研究開発プログラム), 主任研究員 (40805644)
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| 研究分担者 |
MEI RAN 国立研究開発法人海洋研究開発機構, 超先鋭研究開発部門(超先鋭研究開発プログラム), 外国人特別研究員
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| 研究期間 (年度) |
2023-03-08 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
2,200千円 (直接経費: 2,200千円)
2024年度: 600千円 (直接経費: 600千円)
2023年度: 500千円 (直接経費: 500千円)
2022年度: 1,100千円 (直接経費: 1,100千円)
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| キーワード | Archaea / Genomics / Evolution / Bioinformatics / Genes |
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| 研究開始時の研究の概要 |
We have massive amounts of genomic insight into life on Earth, yet the data remains challenging to explore due to the lack of organization - only a small fraction of genes have known biochemical function. However, we need not know genes’ functions to extract useful information. One approach to explore genetic space is combination of cutting-edge gene clustering algorithms and evolution reconstruction tools.
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| 研究実績の概要 |
Based on the clustering of genes from all publicly available archaea genomes into homologous groups using the workstation purchased with this grant, we reconstructed the evolutionary history of nearly half of the protein groups. This was performed through construction of rooted phylogenetic trees for each protein group and estimation of the simplest evolutionary scheme using these gene trees, a tree of life spanning all analyzed genomes, and duplication, transfer, and loss reconciliation. In doing so, the origin of each protein group and which lineages vertically or horizontally inherited or lost the functions could be predicted.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Tree estimation and duplication, transfer, loss reconciliation are time-consuming but in-house approaches for reducing calculation times allowed for rapid analysis.
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| 今後の研究の推進方策 |
Phylogenetic analyses of the remaining protein groups will be completed in the early half of the 2024 fiscal year. With a holistic view of the evolution of functions across the tree of archaeal life, we can begin to reconstruct the evolutionary background and relationships behind contemporary and ancient lifestyles. The obtained detailed evolutionary view of archaea will also be used to provide quantitative data regarding the evolution of archaea. The duplication, transfer, and loss rates in bacteria have been explored, but data/analyses remain scarce for archaea. Without such information, the fundamental evolutionary characteristics of the two domains of prokaryotic life cannot be compared. Here, in the following months, we aim to complete such a comparison to provide a clear view of the evolutionary differences between the two domains.
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