| 研究課題/領域番号 |
22KK0147
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| 研究種目 |
国際共同研究加速基金(国際共同研究強化(B))
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| 配分区分 | 基金 |
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| 審査区分 |
中区分58:社会医学、看護学およびその関連分野
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| 研究機関 | 長崎大学 |
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研究代表者 |
吉田 レイミント 長崎大学, 熱帯医学研究所, 教授 (90432963)
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| 研究分担者 |
樋泉 道子 長崎大学, 熱帯医学研究所, 准教授 (00778623)
柳原 克紀 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40315239)
森内 浩幸 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90315234)
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| 研究期間 (年度) |
2022-10-07 – 2025-03-31
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| 研究課題ステータス |
交付 (2022年度)
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| 配分額 *注記 |
20,020千円 (直接経費: 15,400千円、間接経費: 4,620千円)
2024年度: 5,720千円 (直接経費: 4,400千円、間接経費: 1,320千円)
2023年度: 7,410千円 (直接経費: 5,700千円、間接経費: 1,710千円)
2022年度: 6,890千円 (直接経費: 5,300千円、間接経費: 1,590千円)
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| キーワード | Hepatitis B Virus / Hepatitis C Virus / Hepatitis D Virus / incidence / genotype / drug resistant variant / Nigeria / Viral hepatitis / drug resistant / therapeutic |
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| 研究開始時の研究の概要 |
DNA/RNA will be extracted from HBV and HCV positive serum samples stored at Nigeria CDC. PCR and sequencing will be performed to determine the genotype, drug resistant variants and predict optimal viral hepatitis therapeutic options. A rapid PCR based genotyping assays will be developed.
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| 研究実績の概要 |
Necessary ethical approvals and Material Transfer Agreement have been obtained to conduct the study. A Nigeria PhD student, studying under the principal investigator at Nagasaki University visited Nigeria CDC to conduct the DNA extraction from 251 Hepatitis B positive samples and transported to Nagasaki University. The epidemiological information database of the viral hepatitis positive subjects has been obtained from Nigeria CDC.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The necessary ethical approvals and MTA have been completed. The epidemiological data of the viral hepatitis survey and the first batch of HBV positive samples have been obtained. The data analysis and sample testing processes are progressing well as planed.
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| 今後の研究の推進方策 |
2023 plan: The Japan research team plans to visit Nigeria CDC this year to discuss the ongoing data analysis and sample testing plan with the Nigeria CDC counterparts. Nucleic acid extraction of Hepatitis B Virus and Hepatitis C Virus samples will will be done. The samples will be transported to Nagasaki University for genotyping, drug resistant variant testing and whole genome sequencing analyses.
2024 plan: Further sample testing and data analysis will be done next year. The result of the study will be presented at domestic and international conference.
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