難治性心不全を克服するバイオニック自律神経制御システムの基盤研究

• 研究課題/領域番号: 23220013
• 研究種目: 基盤研究(S)
• 配分区分: 補助金
• 研究分野: 医用生体工学・生体材料学
• 研究機関: 九州大学
• 研究代表者: 砂川 賢二 九州大学, 学内共同利用施設等, 研究員 (50163043)
• 研究分担者: 岸 拓弥 九州大学, 循環器病未来医療研究センター, 准教授 (70423514) ; 廣岡 良隆 九州大学, 循環器病未来医療研究センター, 准教授 (90284497) ; 井手 友美 九州大学, 医学研究院, 講師 (90380625)
• 研究期間 (年度): 2011-04-01 – 2016-03-31
• 研究課題ステータス: 完了 (2015年度)
• 配分額: 214,760千円 (直接経費: 165,200千円、間接経費: 49,560千円); 2015年度: 42,640千円 (直接経費: 32,800千円、間接経費: 9,840千円); 2014年度: 42,640千円 (直接経費: 32,800千円、間接経費: 9,840千円); 2013年度: 42,640千円 (直接経費: 32,800千円、間接経費: 9,840千円); 2012年度: 42,640千円 (直接経費: 32,800千円、間接経費: 9,840千円); 2011年度: 44,200千円 (直接経費: 34,000千円、間接経費: 10,200千円)
• キーワード: 生体制御・治療 / 自律神経制御 / 循環制御 / 心不全 / バイオニック

研究成果の概要

自律神経系は心不全の病態の進展に深く関わっている。心不全は高齢者に多発するが高齢者では動脈硬化などで自律神経を制御する圧反射機能が低下している。本研究では圧反射機能の低下が心不全の発症に重要な役割を果たすことを証明するとともに、電子的に自律神経に介入し圧反射機能を再構成するバイオニック自律神経制御システムの開発を目指した。その結果、圧反射機能の低下は交感神経の緊張をもたらし有効循環血液量を増加させること、また腎臓の圧利尿特性を右方に移動させ利尿が減ることが示された。バイオニック自律神経制御システムは容量耐性を正常化させることが明らかになった。

評価記号

検証結果 (区分)

A

研究成果

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• [雑誌論文] Nanoparticle-Mediated Delivery of Pioglitazone Enhances Therapeutic Neovascularization in a Murine Model of Hindlimb Ischemia. (2012)
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• [雑誌論文] Combination therapy of atorvastatin and amlodipine inhibits sympathetic nervous system activation and improves cognitive function in hypertensive rats. (2012)
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• [雑誌論文] Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats. (2012)
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• [雑誌論文] Sympathoinhibition caused by orally administered telmisartan through inhibition of the AT₁ receptor in the rostral ventrolateral medulla of hypertensive rats. (2012)
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• [雑誌論文] Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells. (2012)
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• [雑誌論文] Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats. (2012)
  • 著者名/発表者名: Shinohara K, Hirooka Y, Ogawa K, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
  • 雑誌名: Clin Exp Hypertens 巻: 34(6) 号: 6 ページ: 456-62
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• [雑誌論文] Beraprost sodium, a stable prostacyclin analogue, improves insulin resistance in high-fat diet-induced obese mice. (2012)
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• [雑誌論文] Acetylcholinesterase Inhibitors Attenuate Angiogenesis (2012)
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  • 雑誌名: Clinical Science 巻: (In press) 号: 4 ページ: 241-249
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• [雑誌論文] Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. (2012)
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  • 査読あり
• [雑誌論文] Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats. (2012)
  • 著者名/発表者名: Nishihara M, Hirooka Y, Matsukawa R, Kishi T, Sunagawa K.
  • 雑誌名: J Hypertens 巻: 30(1) 号: 1 ページ: 97-106
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  • 査読あり
• [雑誌論文] Decreased brain sigma-1 receptor contributes to the relationship between heart failure and depression. (2012)
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  • 査読あり
• [雑誌論文] Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats (2012)
  • 著者名/発表者名: Nishihara M, et al
  • 雑誌名: J Hypertens 巻: 30 ページ: 97-106
  • 査読あり
• [雑誌論文] Acetylcholinesterase Inhibitors Attenuate Angiogenesis (2012)
  • 著者名/発表者名: Miyazaki R, et al
  • 雑誌名: Clin Sci (Lond) 巻: (印刷中)
  • 査読あり
• [雑誌論文] Beraprost sodium, a stable prostacyclin analogue, improves insulin resistance in high-fat diet-induced obese mice (2012)
  • 著者名/発表者名: Inoue E, et al
  • 雑誌名: J Endocrinol 巻: (印刷中)
  • 査読あり
• [雑誌論文] Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension (2011)
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  • 雑誌名: Am J Physiol Regul Integr Comp Physiol 巻: 300
  • 査読あり
• [雑誌論文] Peak systolic mitral annulus velocity reflects the status of ventricular-arterial coupling-theoretical and experimental analyses (2011)
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  • 雑誌名: J Am Soc Echocardiogr 巻: 24 ページ: 582-591
  • 査読あり
• [雑誌論文] Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation (2011)
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  • 雑誌名: Cardiovasc Res 巻: 91 ページ: 711-719
  • 査読あり
• [雑誌論文] Role of angiotensin-(1-7) in rostral ventrolateral medulla in blood pressure regulation via sympathetic nerve activity in Wistar-Kyoto and spontaneous hypertensive rats (2011)
  • 著者名/発表者名: Nakagaki T, et al
  • 雑誌名: Clin Exp Hypertens 巻: 33 ページ: 223-230
  • 査読あり
• [雑誌論文] Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats (2011)
  • 著者名/発表者名: Kishi T, et al
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  • 査読あり
• [雑誌論文] Neuregulin-1/ErbB signaling in rostral ventrolateral medulla is involved in blood pressure regulation as an antihypertensive system (2011)
  • 著者名/発表者名: Matsukawa R, et al
  • 雑誌名: J Hypertens 巻: 29 ページ: 1735-1742
  • 査読あり
• [雑誌論文] Brain AT1 receptor activates the sympathetic nervous system through toll-like receptor 4 in mice with heart faile J Cardiovasc Pharmacol (2011)
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  • 査読あり
• [雑誌論文] Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor (2011)
  • 著者名/発表者名: Matsuura H, et al
  • 雑誌名: Hypertension 巻: 58 ページ: 386-393
  • 査読あり
• [雑誌論文] matinib mesylate-incorporated nanoparticle-eluting stent attenuates in-stent neointimal formation in porcine coronary arteries (2011)
  • 著者名/発表者名: Masuda S, et al
  • 雑誌名: J Atheroscler Thromb 巻: 18 ページ: 1043-1053
  • 査読あり
• [雑誌論文] Consideration on step duration to assess open-loop static characteristics of the carotid sinus baroreflex in rats (2011)
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  • 雑誌名: Conf Proc IEEE Eng Med Biol Soc 巻: 2011 ページ: 689-692
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• [雑誌論文] Artificial baroreflex system restores volume tolerance in the absence of native baroreflex (2011)
  • 著者名/発表者名: Hosokawa K, et al
  • 雑誌名: Conf Proc IEEE Eng Med Biol Soc 巻: 2011 ページ: 697-699
  • 査読あり
• [雑誌論文] Experimental 'jet lag' causes sympathoexcitation via oxidative stress through AT1 receptor in brainstem (2011)
  • 著者名/発表者名: Kishi T, Sunagawa K
  • 雑誌名: Conf Proc IEEE Eng Med Biol Soc 巻: 2011 ページ: 1969-1972
  • 査読あり
• [雑誌論文] Impact of baroreflex on venous return surface (2011)
  • 著者名/発表者名: Sakamoto T, et al
  • 雑誌名: Conf Proc IEEE Eng Med Biol Soc 巻: 2011 ページ: 4295-4296
  • 査読あり
• [雑誌論文] Reduction of myocardial oxygen demand by controlling heart rate and hemodynamics simultaneously by novel circulatory model (2011)
  • 著者名/発表者名: Sugimachi M, et al
  • 雑誌名: Conf Proc IEEE Eng Med Biol Soc 巻: 2011 ページ: 4297-4300
  • 査読あり
• [学会発表] Synergy of Neuro-Mechanical Unloading Strikingly Reduces the Infarct Size and Prevents Chronic Heart Failure in Ischemia Reperfusion Model. (2016)
  • 著者名/発表者名: Arimura T, Saku K, Kakino T, Tohyama T, Nishikawa T, Murayama Y, Kishi T, Ide T, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] Twinkle Helicase Overexpression Prevents Cardiac Rupture after Myocardial Infarction by Alleviating Mitochondrial Insufficiency. (2016)
  • 著者名/発表者名: Ikeda M, Ide T, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] Increased Expression of Thrombin Receptor, PAR1 is a New Therapeutic Target for Pulmonary Hypertension. (2016)
  • 著者名/発表者名: Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] Carotid Body Denervation Improves Survival via Sympatho-inhibition in Hypertensive Heart Failure. (2016)
  • 著者名/発表者名: Fujii K, Saku K, Kishi T, Nishizaki A, Oga Y, Arimura T, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] The Early Anti-inflammatory Responses of Vagal Nerve Stimulation Plays a Pivotal Role in Improving Chronic Heart Failure after Myocardial Infarction. (2016)
  • 著者名/発表者名: Nishizaki A, Saku K, Oga Y, Kuwabara Y, Arimura T, Fujii K, Tohyama T, Nishikawa T, Kishi T, Ide T, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] Electrical Baroreflex Activation Improves Volume Load Induced Worsening of Heart Failure with Reduced Ejection Fraction. (2016)
  • 著者名/発表者名: Oga Y, Sakamoto T, Saku K, NIshizaki A, Arimura T, Fujii K, Tohyama T, Nishikawa T, Murayama Y, Kishi T, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] Critical Protective Role of Endogenous Nitric Oxide in Severe Pulmonary Arterial Hypertension in Rats. (2016)
  • 著者名/発表者名: Tanaka M, Abe K, Oka M, Schwenki D, Shirai M, Kuwahira I, Hirooka Y, Hoka S, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] Acute Inflammation Activates the Sympathetic Nervous System by Resetting the Central Arc and Desensitizes the Peripheral Arc to Sympathoexcitation. (2016)
  • 著者名/発表者名: Tohyama T, Saku K, Oga Y, Nishikawa T, Fujii K, Nishizaki A, Kishi T, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] NF-κB-Mediated Inflammation Plays a Key Role in Deteriorating RV Function in Pulmonary Artery Banding Rats. (2016)
  • 著者名/発表者名: Yoshida K, Abe K, Tanaka M, Shinoda M, Kuwabara Y, Saku K, Hirooka Y, Oka M, Sunagawa K.
  • 学会等名: 第80回日本循環器学会学術集会
  • 発表場所: 仙台
  • 年月日: 2016-03-18
• [学会発表] ntravascular Vagal Nerve Stimulation in Acute Myocardial Infarction Markedly Reduced Infarct Size and Improved Cardiac Function in the Long Term. (2015)
  • 著者名/発表者名: Arimura T, Saku K, Kakino T, Akashi T, Nishikawa T, Mirayama Y, Takehara T, Ide T, Takuya K, Sunagawa K.
  • 学会等名: Scientific Sessions 2015 of the American Heart Association
  • 発表場所: Orland
  • 年月日: 2015-11-07
  • 国際学会
• [学会発表] Transvascular Total Left Ventricular Unloading for Acute Myocardial Infarction Strikingly Reduced Myocardial Oxygen Consumption, Limited the Infarct Size and Prevented Heart Failure in the long term (2015)
  • 著者名/発表者名: Arimura T, Saku K, Kakino T, Akashi T, Murayama Y, Nishikawa T, Tohyama T, Ide T, Kishi T, Sunagawa K.
  • 学会等名: Scientific Sessions 2015 of the American Heart Association
  • 発表場所: Orland
  • 年月日: 2015-11-07
  • 国際学会
• [学会発表] Proteinase-activated Receptor 1 Antagonist Inhibited the Progression of Monocrotaline Induced Pulmonary Hypertension in Rats. (2015)
  • 著者名/発表者名: Kuwabara Y, Abe K, Sunagawa K
  • 学会等名: Scientific Sessions 2015 of the American Heart Association
  • 発表場所: Orland
  • 年月日: 2015-11-07
  • 国際学会
• [学会発表] Input Impedance Analysis Of Pulmonary Hypertension Models Indicates That Monocrotaline And Sugen/hypoxia Induce Mechanically Different Vascular Remodeling (2015)
  • 著者名/発表者名: Nishikawa T, Saku K, Sunagawa K
  • 学会等名: Scientific Sessions 2015 of the American Heart Association
  • 発表場所: Orland
  • 年月日: 2015-11-07
  • 国際学会
• [学会発表] The anesthetized Rat Model of Exercise Faithfully Simulates Respiratory Abnormalities in Chronic Heart Failure (2015)
  • 著者名/発表者名: Nishizaki A, Saku K, Oga Y, Fujii K, Arimura T, Takehara T, Akashi T, Murayama Y, Kishi T, Ide T, Sunagawa K.
  • 学会等名: Scientific Sessions 2015 of the American Heart Association
  • 発表場所: Orland
  • 年月日: 2015-11-07
  • 国際学会
• [学会発表] VNS Induced Early Suppression of The Excessive Inflammatory Response May Contribute to Its Beneficial Effects on Chronic Heart Failure. (2015)
  • 著者名/発表者名: Nishizaki A, Saku K, Oga Y, Fujii K, Arimura T, Takehara T, Akashi T, Murayama Y, Kishi T, Ide T, Sunagawa K.
  • 学会等名: Scientific Sessions 2015 of the American Heart Association
  • 発表場所: Orland
  • 年月日: 2015-11-07
  • 国際学会
• [学会発表] Carotid Body Denervation Improves Survival with Sympatho-inhibition in Rats with Hypertensive Heart Failure. (2015)
  • 著者名/発表者名: Fujii K, Saku K, Oga Y, Nishizaki A, Takehara T, Akashi T, Kishi T, Sunagawa K.
  • 学会等名: 第19回日本心不全学会学術集会
  • 発表場所: 大阪
  • 年月日: 2015-10-22
• [学会発表] The Akt-mTOR Axis is a Pivotal Regulator of Eccentric Hypertrophy during Volume Overload. (2015)
  • 著者名/発表者名: Ikeda M, Ide T, Fujino T, Sunagawa K.
  • 学会等名: 第19回日本心不全学会学術集会
  • 発表場所: 大阪
  • 年月日: 2015-10-22
• [学会発表] Chronic Heart Failure Markedly Attenuates the Low Pressure Baroreflex in Regulating Sympathetic Function in Rats. (2015)
  • 著者名/発表者名: Oga Y, Kishi T, Saku K, Nishizaki A, Arimura T, Fujii K, Tohyama T, Nishikawa T, Ide T, Sunagawa K.
  • 学会等名: 第19回日本心不全学会学術集会
  • 発表場所: 大阪
  • 年月日: 2015-10-22
• [学会発表] Right Ventricular Pressure-Volume Relationship to Evaluate Right ventricular-Pulmonary Aeterial Coupling and Energetics. (2015)
  • 著者名/発表者名: Sakamoto T, Abe K, Hosokawa K, Oi K, Mukai Y, Yamazaki Y, Nagao M, Ide T, Sunagawa K.
  • 学会等名: 第19回日本心不全学会学術集会
  • 発表場所: 大阪
  • 年月日: 2015-10-22
• [学会発表] The Neuro-Mechanical Unloading for Acute Myocardial Infarction Markedly Reduce the Infarct Size and Prevents Heart Failure in the Long Term. (2015)
  • 著者名/発表者名: Saku K, Arimura T, Kakino T, Sakamoto T, Tohyama T, Nishikawa T, Akashi T, Kishi T, Ide T, Sunagawa K.
  • 学会等名: 第19回日本心不全学会学術集会
  • 発表場所: 大阪
  • 年月日: 2015-10-22
• [学会発表] 心不全はどこの、どんな病気としてとらえたらよいのか (2015)
  • 著者名/発表者名: 砂川賢二
  • 学会等名: 第19回日本心不全学会学術集会
  • 発表場所: 大阪
  • 年月日: 2015-10-11
• [学会発表] Is renal nerve ablation a sound therpeutic strategy for the clinical treatment of HT? Insights gleaned from recent studies. (2015)
  • 著者名/発表者名: Nishizaki A, Saku K, Sunagawa K.
  • 学会等名: 25th Annual American Autonomic Society
  • 発表場所: Streasa
  • 年月日: 2015-09-26
  • 国際学会
• [学会発表] The vagal pathway to the viscera: from basic mechnisms to therapeotic applications. (2015)
  • 著者名/発表者名: Nishizaki A, Saku K, Sunagawa K.
  • 学会等名: 25th Annual American Autonomic Society
  • 発表場所: Streasa
  • 年月日: 2015-09-26
  • 国際学会
• [学会発表] Transvascular total left ventricular unloading in the acute phase of myocardial infarction markedly reduces infarct size and prevents heart failure in the long term. (2015)
  • 著者名/発表者名: Saku K, Sunagawa K.
  • 学会等名: European Society of Cardiology congress 2015
  • 発表場所: London
  • 年月日: 2015-08-31
  • 国際学会
• [学会発表] The Development of Pulmonary Artery Input Impedance in Experimental Pulmonary Hypertension. (2015)
  • 著者名/発表者名: Nishikawa T, Saku K, Sakamoto T, Kishi T, Sunagawa K.
  • 学会等名: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Milano
  • 年月日: 2015-08-25
  • 国際学会
• [学会発表] Baroreflex Activation Induced Sympathoinhibition Markedly Improves Hemodynamics in Rats with Reduced Ejection Fraction. (2015)
  • 著者名/発表者名: Oga Y, Sakamoto T, Saku K, Tohyama T, Nishikawa T, Murayama Y, Akashi T, Kishi T, Sunagawa K.
  • 学会等名: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Milano
  • 年月日: 2015-08-25
  • 国際学会
• [学会発表] Autonomic Regulation of the Pressure-Volume Relationship and Hemodynamics in Normal and Heart Failure. (2015)
  • 著者名/発表者名: Sakamoto T, Sunagawa K
  • 学会等名: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Milano
  • 年月日: 2015-08-25
  • 国際学会
• [学会発表] All about the Pressure-Volume Relationship of the Heart: From bench to Bedside and Beyond. (2015)
  • 著者名/発表者名: Sunagawa K.
  • 学会等名: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Milano
  • 年月日: 2015-08-25
  • 国際学会
• [学会発表] Closed Loop Neuromodulation in Cardiovascular Disease (2015)
  • 著者名/発表者名: Sunagawa K, Saku K, Hosokawa K, Oga Y.
  • 学会等名: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Milano
  • 年月日: 2015-08-25
  • 国際学会
• [学会発表] Experimental Acute Inflammation Induces Sympatho-Excitation Via the Resetting Baroreflex Neural Arc (2015)
  • 著者名/発表者名: Tohyama T, Saku K, Nishikawa T, Oga Y, Takehara T, Akashi T, Kishi T, Ide T, Sunagawa K.
  • 学会等名: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Milano
  • 年月日: 2015-08-25
  • 国際学会
• [学会発表] Carotid Body Denervation Attenuates Sympathetic Nerve Activity, Shifts the Pressure-Diuresis Curve to the Left and Improves Survival in rats with Hypertensive Heart Failure (2015)
  • 著者名/発表者名: Fujii K, Saku K, KIshi T, Takehara T, Akashi T, Oga Y, NIshizaki A, Arimura T, Tohyama T, Nishikawa T, Sunagawa K.
  • 学会等名: Experimental Biology 2015
  • 発表場所: San Diego
  • 年月日: 2015-04-01
  • 国際学会
• [学会発表] The Symptom Limited Up-titration of VNS May be Too Strong to Benefit Chronic Heart Failure before improving hemodynamics (2015)
  • 著者名/発表者名: Nishizaki A, Saku K, Akashi T, Takehara T, Oga Y, Arimura T, Fujii K, Kishi T, Ide T, Sunagawa K.
  • 学会等名: Experimental Biology 2015
  • 発表場所: San Diego
  • 年月日: 2015-04-01
  • 国際学会
• [学会発表] Chronic Heart Failure Blunts the Low Pressure Baroreflex Induced Biphasic Change of Sympathetic Nerve Activity (2015)
  • 著者名/発表者名: Oga Y, Kishi T, Saku K, Kakino T, Nishizaki A, Arimura T, Fujii K, Tohyama T, Nishikawa T, Sunagawa K.
  • 学会等名: Experimental Biology 2015
  • 発表場所: San Diego
  • 年月日: 2015-04-01
  • 国際学会
• [学会発表] Carotid Body Denervation Markedly Improves the Survival of Monocrotaline Induced Pulmonary Hypertension Rats. (2015)
  • 著者名/発表者名: Shinoda M, Saku K, Abe K, Takehara T, Kuwabara Y, Yoshida K, Fujii K, Nishizaki A, Oga Y, Sunagawa K.
  • 学会等名: Experimental Biology 2015
  • 発表場所: San Diego
  • 年月日: 2015-04-01
  • 国際学会
• [学会発表] Neural unloading using intravenous vagal nerve stimulation for acute myocardial infarction (AMI) improves cardiac function and prevents heart failure in the long term (2015)
  • 著者名/発表者名: Arimura T, Saku K, Kakino T, Akashi T, Nishikawa T, Murayama Y, Takehara T, Ide T, Kishi T, Sunagawa K.
  • 学会等名: Ｅｘｐｅｒｉｍｅｎｔａｌ Ｂｉｏｌｏｇｙ 2015
  • 発表場所: 米国 ボストン
  • 年月日: 2015-03-28 – 2015-04-01
• [学会発表] Carotid Body Denervation Attenuates Sympathetic Nerve Activity, Shifts the Pressure-Diuresis Curve to the Left and Improves Survival in rats with Hypertensive Heart Failure (2015)
  • 著者名/発表者名: Fujii K, Saku K, Kishi T, Akashi T, Oga Y, Nishizaki A, Arimura T, Tohyama T, Nishikawa T, Sunagawa K.
  • 学会等名: Ｅｘｐｅｒｉｍｅｎｔａｌ Ｂｉｏｌｏｇｙ 2015
  • 発表場所: 米国 ボストン
  • 年月日: 2015-03-28 – 2015-04-01
• [学会発表] Intravenous vagal nerve stimulation in acute myocardial infarction (AMI) markedly improves cardiac function and prevents chronic heart failure (2015)
  • 著者名/発表者名: Arimura T, Saku K, Kakino T, Akashi T, Murayama Y, Nishikawa T, Toyama T, Takehara T, Ide T, Kishi T, Sunagawa K
  • 学会等名: ACC 2015
  • 発表場所: 米国サンディエゴ
  • 年月日: 2015-03-15 – 2015-03-16
• [学会発表] Afferent Vagal Nerve Stimulation Dose Dependently Inhibits Sympathetic Nerve Activity Through the Resetting of Baroreflex Central Arc (2014)
  • 著者名/発表者名: Oga Y, Kishi T, Saku K, Kakino T, Nishizaki A, Fujii K, Arimura T, Ikeda M, Ide T, Sunagawa K.
  • 学会等名: AHA 2014
  • 発表場所: 米国シカゴ
  • 年月日: 2014-11-15 – 2014-11-19
• [学会発表] Discordant Impact of Baroreflex Activation on Cardiac Output Between the Normal Heart and Failing Heart (2014)
  • 著者名/発表者名: Sakamoto T, Kakino T, Saku K, Sakamoto K, Hosokawa K, Sunagawa K.
  • 学会等名: AHA 2014
  • 発表場所: 米国シカゴ
  • 年月日: 2014-11-15 – 2014-11-19
• [学会発表] Differential impacts of vagal nerve stimulus frequency on heart rate and respiration (2014)
  • 著者名/発表者名: Nishizaki A, Saku K, Kakino T, Ikeda M, Oga Y, Kuwabara Y, Ide T, Kishi T, Sunagawa K.
  • 学会等名: 25th Annual American Autonomic Society
  • 発表場所: プエルトリコ
  • 年月日: 2014-11-04 – 2014-11-08
• [学会発表] 経静脈的迷走神経刺激は急性心筋梗塞の梗塞サイズを著減させ、慢性期の心不全を改善させる (2014)
  • 著者名/発表者名: 有村貴博、朔啓太、柿野貴盛、赤司卓也、村山佳範、竹原孝子、西崎晶子、大賀泰寬、池田昌隆、藤井香菜、井手友美、岸拓弥、砂川賢二
  • 学会等名: 第18回日本心不全学会学術集会
  • 発表場所: 大阪
  • 年月日: 2014-10-10 – 2014-10-12
• [学会発表] Concomitant therapy with vagal nerve stimulation (VNS) and total flow support of left ventricular assist device (LVAD) maximally suppresses the infarct size in ischemia reperfusion (IR) model (2014)
  • 著者名/発表者名: Kakino T, Saku K, Arimura T, Akashi T, Sakamoto T, Murayama Y, Nishizaki A, Oga Y, Kishi T, Ikeda M, Ide T, Sunagawa K.
  • 学会等名: ESC 2014
  • 発表場所: バルセロナ
  • 年月日: 2014-08-30 – 2014-09-03
• [学会発表] Estimation of Left Ventricular End-Systolic Elastance on Veno-Arterial Extracorporeal Membrane Oxygenation (2014)
  • 著者名/発表者名: Nishikawa T, Kakino T, Saku K, Kishi T, Sunagawa K.
  • 学会等名: IEEE EMBC 2014
  • 発表場所: 米国 シカゴ
  • 年月日: 2014-08-25 – 2014-08-30
• [学会発表] 心不全モデルラットの麻酔下坐骨神経刺激は心不全における運動時呼吸パターン異常の再現モデルである (2014)
  • 著者名/発表者名: 西崎晶子、宮本忠吉、朔啓太、上田真也、井手友美、岸拓弥、砂川賢二
  • 学会等名: 第20回日本心臓リハビリテーション学会学術集会
  • 発表場所: 京都
  • 年月日: 2014-07-19 – 2014-07-20
• [学会発表] 左室補助装置 (LVAD)によるTotal unloadingは著明な左室酸素消費量の低下をもたらす (2014)
  • 著者名/発表者名: 有村貴博、朔啓太、柿野貴盛、赤司卓也、竹原孝子、西崎晶子、大賀泰寬、池田昌隆、藤井香菜、井手友美、砂川賢二
  • 学会等名: 第53回日本生体医工学会大会
  • 発表場所: 仙台
  • 年月日: 2014-06-24 – 2014-06-26
• [学会発表] Intravascular electrical stimulation of carotid sinus activates baroreflex and decreases arterial pressure in an anesthetized dog (2014)
  • 著者名/発表者名: Sakamoto T, Saku K, Kakino T, Arimura T, Sunagawa K.
  • 学会等名: 第53回日本生体医工学会大会
  • 発表場所: 仙台
  • 年月日: 2014-06-24 – 2014-06-26
• [学会発表] Development of a rat model of exercise under anesthesia capable of reproducing abnormal respiratory responses in Chronic Heart Failure (2014)
  • 著者名/発表者名: Nishizaki A, Miyamoto T, Saku K, Ueda S, Manabe K, Kishi T, Kakino T, Oga Y, Arimura T, Fujii K, Ide T, Sunagawa K.
  • 学会等名: Ｅｘｐｅｒｉｍｅｎｔａｌ Ｂｉｏｌｏｇｙ 2014
  • 発表場所: 米国 サンディエゴ
  • 年月日: 2014-04-26 – 2014-04-30
• [学会発表] Transvenous vagal nerve stimulation (VNS) in acute myocardial infarction (AMI) markedly reduces the infarction size and improves chronic cardiac function (2014)
  • 著者名/発表者名: Arimura T, Saku K, Kakino T, Akashi T, Takehara T, Nishizaki A, Oga Y, Fujii K, Ikeda M, Ide T, Kishi T, Sunagawa K.
  • 学会等名: Ｅｘｐｅｒｉｍｅｎｔａｌ Ｂｉｏｌｏｇｙ 2014
  • 発表場所: 米国 サンディエゴ
  • 年月日: 2014-04-26 – 2014-04-30
• [学会発表] The Increase of Mitochondrial DNA Copy Number Attenuates Eccentric Cardiac Remodeling In Volume Overload Model. (2013)
  • 著者名/発表者名: Ikeda M, Ide T, Fujino T, Hata Y, Takehara T, Onitsuka K, Tobushi T, Sakamoto K, Saku K, Kakino T, Tyynismaa H, Suomalainen A, Sunagawa K.
  • 学会等名: Experimental Biology 2013
  • 発表場所: Boston, U.S.A.
• [学会発表] Central Sympathoinhibition Ameliorates the Reduction of Splenic Regulatory T Cells with Decreased IL-17 Production in Hypertensive Rats (2013)
  • 著者名/発表者名: Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
  • 学会等名: Experimental Biology 2013
  • 発表場所: Boston, U.S.A.
• [学会発表] Azilsartan, New Angiotensin II Type 1 Receptor Blocker, Would Suppress Morning Surge in Hypertension. (2013)
  • 著者名/発表者名: Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
  • 学会等名: Experimental Biology 2013
  • 発表場所: Boston, U.S.A.
• [学会発表] Quantitative Prediction of Impact of Left Ventricular Assist Device (LVAD) on Hemodynamics. (2013)
  • 著者名/発表者名: Kakino T, Saku K, Sakamoto T, Sakamoto K, Akashi T, Tobushi T, Murayama Y, Fujino T, Onitsuka K, Ikeda M, Oga Y, Nishizaki A, Kuwabara Y, Ide T, Sunagawa K.
  • 学会等名: Experimental Biology 2013
  • 発表場所: Boston, U.S.A.
• [学会発表] Central sympathoinhibition by moxonidine attenuates brain oxidative stress, prevents cardiac remodeling and improves prognosis associated with reduction of sympathetic hyperactivity in rats with hypertensive heart failure. (2013)
  • 著者名/発表者名: Honda N, Hirooka Y, Matsukawa R, Ito K, Sunagawa K.
  • 学会等名: Experimental Biology 2013
  • 発表場所: Boston, U.S.A.
• [学会発表] Afferent Vagal Nerve Stimulation Resets the Baroreflex Neural Arc and Inhibits Sympathetic Nerve Activity. (2013)
  • 著者名/発表者名: Saku K, Sakamoto K, Hosokawa K, Kakino T, Ikeda M, Oga Y, Nishizaki A, Ide T, Sunagawa K.
  • 学会等名: Experimental Biology 2013
  • 発表場所: Boston, U.S.A.
• [学会発表] Central Sympathoinhibition by Moxonidine Improves Prognosis in Rats with Hypertensive Heart Failure. (2013)
  • 著者名/発表者名: Honda N, Hirooka Y, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] The Increase of Mitochondrial DNA Copy Number Attenuates Eccentric Cardiac Remodeling in Volume Overload Model. (2013)
  • 著者名/発表者名: Ikeda M, Ide T, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Ideal Depressor Effect of New Angiotensin II Receptor Blocker, Azilsartan, Around Rest-To-Active Phase in Hypertensive Rats. (2013)
  • 著者名/発表者名: Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Full Support Left Ventricular Assist Device (LVAD) Remarkably Reduces the Infarct Size in Ischemia Reperfusion Model in Dogs. (2013)
  • 著者名/発表者名: Kakino T, Saku K, Sakamoto K, Sakamoto T, Kishi T, Ide T, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Splenic Regulatory T Cells Were Associated with AT1 Receptors in the Brain in Hypertensive Rats. (2013)
  • 著者名/発表者名: Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] A New Endothelin Receptor Antagonist Macitentan Prevents Endothelin-1 Induced Contraction in Intrapulmonary Arteries in Rats with Severe Pulmonary Arterial Hypertension. (2013)
  • 著者名/発表者名: Kunita M, Abbe K, Hirooka Y, Hirano K, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] High Voltage, Not Age and Blood Pressure, of Stimulus Exaggerates Inducibility of Atrial Fibrillation by Rapid Electrical Stimulation in Hypertensive Rats. (2013)
  • 著者名/発表者名: Nagayama T, Kishi T, Hirooka Y, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Vascular Intrinsic Circadian Rhythm of Vascular Contractility under the Regulation of Clock Gene RORa. (2013)
  • 著者名/発表者名: Saito T, Ide T, Ichiki T, Sunagawa K, Hirano K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Prediction of Hemodynamic Impact of the Venoarterial Extracorporeal Membrane Oxygenation (ECMO). (2013)
  • 著者名/発表者名: Sakamoto K, Kakino T, Saku K, Tanaka A, Sakamoto T, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Baroreflex Induced Changes in Stressed Blood Volume Is the Central Mechanism Preventing Volume Load Induced Pulmonary Edema. (2013)
  • 著者名/発表者名: Sakamoto T, Kakino T, Sakamoto K, Saku K, Sunagawa K
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Concomitant Vagal Stimulation on Top of Left Ventricular Assist Device Markedly Reduces the Infarct Size in Ischemia Reperfusion Model. (2013)
  • 著者名/発表者名: Saku K, Kakino T, Sakamoto K, Kishi T, Ide T, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Closed-Loop Neuromodulation Integrated into the Native Physiology Saves Many Patients with Refractory Cardiovascular Diseases. (2013)
  • 著者名/発表者名: Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Baroreflex Steepens the Renal Pressure-Diuresis Relation and Contributes to Stabilize Body Fluid Equilibrium. (2013)
  • 著者名/発表者名: Tobushi T, Kishi T, Hosokawa K, Murayama Y, Sunagawa K.
  • 学会等名: 35th Annual International Conference of the IEEE Engineering in Medicine & Biology Society 2013
  • 発表場所: Osaka, Japan
• [学会発表] Total unloading of the Left Ventricle by circulatory Assist Device (LVAD) strikingly reduces the infract size in ischemia-reperfusion injury. (2013)
  • 著者名/発表者名: Saku K, Kakino T, Sakamoto K, Sakamoto T, Akashi T, Hata Y, Kishi T, Ide T, Sunagawa K.
  • 学会等名: ESC Congress 2013
  • 発表場所: Amsterdam, Netherlands
• [学会発表] Afferent vagal nerve stimulation induced sympathoinhibition may in part attribute to the beneficial impact of vagal nerve stimulation on heart failure. (2013)
  • 著者名/発表者名: Saku K, Sakamoto K, Onitsuka K, Tobushi T, Oga Y, Nishizaki A, Kakino T, Kishi T, Ide T, Sunagawa K.
  • 学会等名: ESC Congress 2013
  • 発表場所: Amsterdam, Netherlands
• [学会発表] Prediction of hemodynamic impact of the venoarterial Extracorporeal Membrane Oxygenation (ECMO) (2013)
  • 著者名/発表者名: Kakino T, Sakamoto K, Saku K, Sakamoto T, Akashi T, Oga Y, Nishizaki A, Kishi T, Ide T, Sunagawa K.
  • 学会等名: ESC Congress 2013
  • 発表場所: Amsterdam, Netherlands
• [学会発表] Beneficial impact of vagal nerve stimulation on CHF is not stimulus dose dependent. (2013)
  • 著者名/発表者名: Nishizaki A, Sakamoto K, Saku K, Ikeda M, Kakino T, Oga Y, Kuwabara Y, Kishi T, Ide T, Sunagawa K.
  • 学会等名: 24th International Sumposium on the Autonomic Nervous System 2013.
  • 発表場所: The Big Island, Hawaii
• [学会発表] Volume loading evokes biphasic changes in sympathetic nerve activity via vagally mediated low pressure baroreflex. (2013)
  • 著者名/発表者名: Oga Y, Kishi T, Saku K, Kakino T, Ikeda M, Nishizaki A, Kuwabara Y, Ide T, Sunagawa K.
  • 学会等名: 24th International Sumposium on the Autonomic Nervous System 2013.
  • 発表場所: The Big Island, Hawaii
• [学会発表] Afferent vagal nerve stimulation resets the baroreflex neural arc and inhibits sympathetic nerve activity. (2013)
  • 著者名/発表者名: Saku K, Sakamoto K, Oga Y, Nishizaki A, Kishi T, Ide T, Sunagawa K.
  • 学会等名: 24th International Sumposium on the Autonomic Nervous System 2013.
  • 発表場所: The Big Island, Hawaii
• [学会発表] Quantitative synthesis of baroreflex on dynamic circulatory equilibrium: model based analysis and experimental validation. (2013)
  • 著者名/発表者名: Sakamoto T, Sunagawa K.
  • 学会等名: 24th International Sumposium on the Autonomic Nervous System 2013.
  • 発表場所: The Big Island, Hawaii
• [学会発表] Central Sympathoinhibition by Moxonidine Attenuated Brain Oxidative Stress, Prevented Cardiac Dysfunction and Improved Prognosis in Rats With Hypertensive Heart Failure. (2013)
  • 著者名/発表者名: Honda N, Hirooka Y, Ito K, Matsukawa R, Sunagawa K.
  • 学会等名: American Heart Association Scientific Sessions 2013
  • 発表場所: Dallas, U.S.A
• [学会発表] Changes in the Vascular Properties, Not the Ventricular Properties, Predominantly Contributes to the Baroreflex Induced Arterial Pressure Regulation. (2013)
  • 著者名/発表者名: Sakamoto T, Kakino T, Saku K, Sakamoto K, Sunagawa K.
  • 学会等名: American Heart Association Scientific Sessions 2013
  • 発表場所: Dallas, U.S.A
• [学会発表] Salt Loading in the Presesnce of Baroreflex Failure Predisposes to Pulmonary Edema in Spontaneously Hypertensive Rat. (2013)
  • 著者名/発表者名: Saku K, Sakamoto K, Kakino T, Oga Y, Nishizaki A, Ikeda M, Kuwahara Y, Kishi T, Sunagawa K.
  • 学会等名: American Heart Association Scientific Sessions 2013
  • 発表場所: Dallas, U.S.A
• [学会発表] Concomitant Vagal Nerve Stimulation With Total Flow Support of Left Ventricular Assist Device Virtually Nullifies the Infarct Size in Ischemia Reperfusion Model. (2013)
  • 著者名/発表者名: Saku K, Kakino T, Akashi T, Sakamoto K, Sakamoto T, Ide T, Kishi T, Sunagawa K.
  • 学会等名: American Heart Association Scientific Sessions 2013
  • 発表場所: Dallas, U.S.A
• [学会発表] Total Left Ventricular Unloading Strikingly Reduces the Infarct Size in Ischemia Reperfusion. (2013)
  • 著者名/発表者名: Kakino T, Saku K, Akashi T, Sakamoto K, Sakamoto T, Kishi T, Ide T, Sunagawa K.
  • 学会等名: American Heart Association Scientific Sessions 2013
  • 発表場所: Dallas, U.S.A
• [学会発表] Crucial Role of Proteinase-Activated Receptor 1 in the Development of Monocrotaline Induced Pulmonary Arterial Hypertension in Rats. (2013)
  • 著者名/発表者名: Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K.
  • 学会等名: American Heart Association Scientific Sessions 2013
  • 発表場所: Dallas, U.S.A
• [学会発表] A Novel Endothelin Receptor Antagonist, Macitentan Markedly Improved Severe Pulmonary Arterial Hypertension in Rats by a Nearly Complete Blockade of Endothelin Receptors. (2013)
  • 著者名/発表者名: Kunita M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K.
  • 学会等名: American Heart Association Scientific Sessions 2013
  • 発表場所: Dallas, U.S.A
• [学会発表] Impact of Bionic Cardiology in the 21st Century: Approaching an Artificial Brain (2013)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: the IEEE Conference on Point of Care Healthcare Technologies
  • 発表場所: インド
  • 招待講演
• [学会発表] 見直しが迫られる交感神経と血圧～脳を標的にした新たな治療戦略～ (2013)
  • 著者名/発表者名: 砂川賢二
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
  • 招待講演
• [学会発表] Abnormal Sympathoexcitation Caused by Brain in Cardiovascular Diseases -Brain is a Novel Therapeutic Target in Cardiovascular Diseases- (2013)
  • 著者名/発表者名: Kishi T et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Central Sympathoinhibition Induced by Blockade of Brain AT1 Receptors Ameliorates the Reduction of Splenic Regulatory T Cells in Hypertensive Rats (2013)
  • 著者名/発表者名: Katsuki M et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Aldosterone-independent MR Activation in the Choroid Plexus Increases Na<SUP>+</SUP> in Cerebrospinal Fluid and Induces Sympathoexcitation in Stroke-Prone Spontaneously Hypertensive Rats (2013)
  • 著者名/発表者名: Nakano M et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] A New Endothelin Receptor Antagonist Macitentan is a Potent Vasodilator in Intrapulmonary Arteries in Rats with Severe Pulmonary Hypertension (2013)
  • 著者名/発表者名: Kunita M et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Impact of Sympathoexcitation and Sympathoinhibition on Heart Failure (2013)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
  • 招待講演
• [学会発表] The Increase of Mitochondrial DNA Copy Number Attenuates Eccentric Cardiac Remodeling in Volume Overload Model (2013)
  • 著者名/発表者名: Ikeda M et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Estimation of Left Ventricular (LV) End-systolic Elastance (Ees) by Using Hemodynamic Changes Introduced by Percutaneous Cardiopulmonary Support (PCPS) (2013)
  • 著者名/発表者名: Kakino T et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Increased Mitochondrial DNA Copy Number Attenuates Excessive Mitochondrial Reactive Oxygen Species and inhibits NFAT Signaling in Cardiac Myocytes (2013)
  • 著者名/発表者名: Fujino T et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Circulating Angiotensin II Leads to Left Ventricular DiastolicDysfunction through Sympathoexcitation with Intrinsic Brain AT<SUB>1</SUB> Receptor Activation (2013)
  • 著者名/発表者名: Shinohara K et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Brain Tumor Necrosis Factor-α Augments Sympathoexcitation and Left Ventricular Remodeling of Heart Failure via Dysfunction of Keap1/Nrf2-mediated Antioxidant in Astrocyte (2013)
  • 著者名/発表者名: Kishi T et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] 新たな時代に入った交感神経と循環器疾患 (2013)
  • 著者名/発表者名: Sunagawa K et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
  • 招待講演
• [学会発表] Chronic Administration of Proteinase-Activated Receptor 1 (PAR1) Antagonist Attenuated Monocrotaline-Induced Pulmonary Hypertension in Rats (2013)
  • 著者名/発表者名: Kuwahara Y et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Baroreflex failure could play a role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF) (2013)
  • 著者名/発表者名: Sakamoto K et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Brain-targeted Intranasal Administration of Viral Inhibition Peptide of Toll-like Receptor 4 Prevents Left Ventricular Remodeling Via Sympathoinhibition in Heart Failure (2013)
  • 著者名/発表者名: Kishi T et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Central Sympathoinhibition by Moxonidine Suppresses Brain Oxidative Stress, Prevents Cardiac Remodeling And Improves Prognosis in Rats with Hypertensive Heart Failure (2013)
  • 著者名/発表者名: Honda S et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Baroreflex induced changes in stressed blood volume is the central mechanism preventing volume load induced pulmonary edema (2013)
  • 著者名/発表者名: Sakamoto T et al
  • 学会等名: 第77回日本循環器学会学術集会
  • 発表場所: 横浜
• [学会発表] Artificial Regulation of Physiological Regulation: Approaching an Artificial Brain. (2013)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: 17th Annual Hilton Head Workshop
  • 発表場所: 米国
  • 招待講演
• [学会発表] Central Sympathoinhibition Improves the Prognosis of Heart Failure in Salt Loading Induced-Hypertensive Rat (2012)
  • 著者名/発表者名: Honda S, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-18
• [学会発表] Mineralocorticoid Receptors Activation in Choroid Piexus Is Involved in Central Nervous System Mechanisms of Hypertension in Stroke-Prone Spontaneously Hypertensive Rats (2012)
  • 著者名/発表者名: Nakano M, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-18
• [学会発表] Renal Afferent Nerve Stimulation Induces Baroreflex Resetting through the Activation of Sympathorenal Axis without Compromising Arterial Pressure Buffering Function (2012)
  • 著者名/発表者名: Tobushi T, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-18
• [学会発表] Combination of Amlodipine and Atorvastatin Causes Sympathoinhibition and Improves Cognitive Function Independent of Blood Pressure-lowering Effects in Hypertensive Rats (2012)
  • 著者名/発表者名: Kishi T, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-18
• [学会発表] Isolated Pure Systolic Stress Upregulates Hypertrophy-related Genes, Whereas Isolated Diastolic Strain Upregulates Fibrosis-related Genes (2012)
  • 著者名/発表者名: Onitsuka K, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-17
• [学会発表] Autoimplantation of Astrocyte into Cardiovascular Center of Brainstem Markedly Improves Survival Rate of Post-myocardial Infarction Heart Failure Rats through Sympathoinhibition (2012)
  • 著者名/発表者名: Kishi T, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-17
• [学会発表] Activation of Mineralocorticoid Receptors in the Rostral Ventrolateral Medulla Enhances Sympathetic Nerve Activity in Stroke-prone Spontaneously Hypertensive rats (2012)
  • 著者名/発表者名: Nakagaki T, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: 国際会議場、福岡
  • 年月日: 2012-03-17
• [学会発表] Chronic Reduction of Oxidative Stress in Paraventricular Nucleus Decreases Heart Rate by Modulating Autonomic Nervous System in Spontaneously Hypertensive Rats (2012)
  • 著者名/発表者名: Nishihara M, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: 国際会議場、福岡
  • 年月日: 2012-03-17
• [学会発表] Blockade of Angiotensin II Type 1 Receptor in the Brain Decreases Angiotensin II-induced Elevated Left Ventricular End-diastolic Pressure via Sympathoinhibition (2012)
  • 著者名/発表者名: Shinohara K, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: 福岡国際センター、福岡
  • 年月日: 2012-03-17
• [学会発表] Baroreflex Modulates Only Stressed Volume Not the Slope of the Venous Return Surface (2012)
  • 著者名/発表者名: Sakamoto T, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-16
• [学会発表] Activation of Central NRG-1/ErbB Signaling Improves Cardiac Function in Heart Failure with Pressure Overload through Sympathoinhibiton (2012)
  • 著者名/発表者名: Matsukawa R, et al
  • 学会等名: 第76回日本循環器学会学術集会
  • 発表場所: マリンメッセ福岡、福岡
  • 年月日: 2012-03-16
• [学会発表] Blockade of brain angiotensinII type1 receptor attenuates angiotensin II-induced left ventricular end-diastolic pressure elevation and myocardial hypertrophy via sympathoinhibition. (2012)
  • 著者名/発表者名: Shinohara K et al
  • 学会等名: Experimental Biology 2012
  • 発表場所: 米国
• [学会発表] Central chemoreflex activation resets the setpoint pressure of baroreflex without compromising its function. (2012)
  • 著者名/発表者名: Saku K et al
  • 学会等名: Experimental Biology 2012
  • 発表場所: 米国
• [学会発表] Renal afferent nerve stimulation induces baroreflex resetting through the activation of sympathorenal axis without compromising arterial pressure buffering function. (2012)
  • 著者名/発表者名: Tobushi T et al
  • 学会等名: Experimental Biology 2012
  • 発表場所: 米国
• [学会発表] Mineralocorticoid receptors activation in choroid plexus and PVN exaggerates salt-induced development of hypertension in stroke-prone spontaneously hypertensive rats. (2012)
  • 著者名/発表者名: Nakano M et al
  • 学会等名: Experimental Biology 2012
  • 発表場所: 米国
• [学会発表] Central angiotensinII induces sympatheoexcitaiton and attenuates the open loop baroreflex gain without altering central baroreflex characteristics. (2012)
  • 著者名/発表者名: Onitsuka K et al
  • 学会等名: Experimental Biology 2012
  • 発表場所: 米国
• [学会発表] Impact of Bionic Cardiology on Refractory Cardiovascular Diseases Approaching an Artificial Brain. (2012)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: Invitation to Workshop in Cleveland Clinic
  • 発表場所: 米国
  • 招待講演
• [学会発表] Impact of electrical vagal stimulation on heart failure (2012)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: Neural Interfaces Conference
  • 発表場所: 米国
  • 招待講演
• [学会発表] Regulation of Cardiovascular Function. Vagal nerve stimulation improves survival in heart failure. (2012)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: 9th International Neurologic and Cardiac Electrophysiology Symposium.
  • 発表場所: タイ
  • 招待講演
• [学会発表] Bionic technology: future promise and remaining problems, when will we ready to meet the cyborg? (2012)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: 9th International Neurologic and Cardiac Electrophysiology Symposium.
  • 発表場所: タイ
  • 招待講演
• [学会発表] The Central Chemoreflex Activation Resets the Arterial Baroreflex Neural Arc without Compromising Its Pressure Buffering Function (2012)
  • 著者名/発表者名: Saku K et al
  • 学会等名: EMBC 2012
  • 発表場所: 米国
• [学会発表] Prediction of Hemodynamic Impact of Percutaneous Cardiopulmonary Bypass (2012)
  • 著者名/発表者名: Kakino T et al
  • 学会等名: EMBC 2012
  • 発表場所: 米国
• [学会発表] Renal Afferent Nerve Stimulation Induces Baroreflex Resetting without Compromising Arterial Pressure Buffering Function (2012)
  • 著者名/発表者名: Tobushi T et al
  • 学会等名: EMBC 2012
  • 発表場所: 米国
• [学会発表] デバイスによる高血圧治療 (2012)
  • 著者名/発表者名: 砂川 賢二
  • 学会等名: 第35回日本高血圧学会
  • 発表場所: 名古屋
  • 招待講演
• [学会発表] Baroreflex induced changes in stressed blood volume, not cardiac output curve, is the central mechanism preventing volume load induced pulmonary edema (2012)
  • 著者名/発表者名: Sakamoto T et al
  • 学会等名: 23rd International Symposium on the Autonomic Nervous System
  • 発表場所: バハマ
• [学会発表] The central chemoreflex activation induces sympathoexcitation and resets the arterial baroreflex without compromising its pressure stabilizing function (2012)
  • 著者名/発表者名: Saku K et al
  • 学会等名: 23rd International Symposium on the Autonomic Nervous System
  • 発表場所: バハマ
• [学会発表] Baroreflex Failure Predisposes to Pulmonary Edema In Conscious Rats with Normal Left Ventricular Function (2012)
  • 著者名/発表者名: Sakamoto K et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Baroreflex Induced Changes in Stressed Blood Volume, Not Cardiac Output Curve, is the Central Mechanism Preventing Volume Load Induced Pulmonary Edema (2012)
  • 著者名/発表者名: Sakamoto T et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Quantitative Prediction of the Hemodynamic Impact of Left Ventricular Assist Device (2012)
  • 著者名/発表者名: Kakino T et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Central Chemoreflex Activation Induces Sympathoexcitation, Whereas Does Not Affect Dynamic or Static Baroreflex Function (2012)
  • 著者名/発表者名: Saku K et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Central Angiotensin II Induces Sympathoexcitation and Attenuates the Open Loop Baroreflex Gain without Altering Central Baroreflex Characteristics (2012)
  • 著者名/発表者名: Onitsuka K et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Renal Afferent Nerve Stimulation Induces Baroreflex Resetting Without Compromising Arterial Pressure Buffering Function (2012)
  • 著者名/発表者名: Tobushi T et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Mineralocorticoid Receptors (MR)/Epithelial Na Channels (ENaCs) Pathway Activation in Choroid Plexus Exaggerates Salt-Induced Hypertension with Sympathoexcitation in Stoke-Prone Spontaneously Hypertensive Rats (2012)
  • 著者名/発表者名: Nakano M et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Cardiac Sympathetic Afferent Stimulation Increases Brain ENaCs, thereby Concomitant Salt Loading Leads to Sympathoexcitation (2012)
  • 著者名/発表者名: Ito K et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Brain Senses the Circulating Angiotensin II Subsequently Leading to Left Ventricular Diastolic Dysfunction through the Central Sympathoexcitation (2012)
  • 著者名/発表者名: Shinohara K et al
  • 学会等名: AHA 2012
  • 発表場所: 米国
• [学会発表] Central NRG-1/ErbB Signaling Has a Pivotal Role in Sympathoexcitation in Heart Failure (2011)
  • 著者名/発表者名: Matsukawa R, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Activation of Mineralocorticoid Receptors in the Rostral Ventrolateral Medulla Enhances Sympathetic Activity in Stroke-Prone Spontaneously Hypertensive Rats (2011)
  • 著者名/発表者名: Nakagaki T, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Inhibition of ROS in the Rostral Ventrolateral Medulla Improves Baroreflex Function in Stroke-Prone Spontaneously Hypertensive Rats (2011)
  • 著者名/発表者名: Ogawa K, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Attenuating ErbB2 Signaling in the Rostral Ventrolateral Medulla Reduces Nitric Oxide Synthesis and Induces Hypertension (2011)
  • 著者名/発表者名: Matsukawa R, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Oral Administration of Telmisartan Causes Sympathoinhibition through the Blockade of AT_1 Receptor in the Cardiovascular Center of Brainstem and the Activation of the Systemic PPAR-γ in Metabolic Syndrome (2011)
  • 著者名/発表者名: Kishi T, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Combination Therapy of Amlodipine with Atorvastatin Suppresses Sympathetic Nerve Activity and Improves Cognitive Function Independent of Depressor Effects (2011)
  • 著者名/発表者名: Kishi T, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Autoimplantation of-Astrocytes into the Cardiovascular Center of Brainstem Causes Sympathoinhibition and Decreases the Mortality Rate in Myocardial Infarction-Induced Heart Failure (2011)
  • 著者名/発表者名: Kishi T, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Inhibition of the Toll-Like Receptor 4 in the Brainstem Causes the Sympathoinhibition and Improves the Left Ventricular Systolic Dysfunction in Heart Failure (2011)
  • 著者名/発表者名: Ogawa K, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-16
• [学会発表] Recombinant Mitochondrial Transcriptional Factor A Protein Attenuates Pathological Remodeling in Cardiac Myocytes (2011)
  • 著者名/発表者名: Fujino T, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland,U.S.A.
  • 年月日: 2011-11-15
• [学会発表] Baroreflex Failure Induces Striking Volume Intolerance In A Rat Model With Normal Left Ventricular Function (2011)
  • 著者名/発表者名: Funakoshi K, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-14
• [学会発表] Artificial Baroreceptor Fully Antagonizes Baroreflex Failure Induced Volume Intolerance (2011)
  • 著者名/発表者名: Hosokawa K, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland, U.S.A.
  • 年月日: 2011-11-14
• [学会発表] Inhibition of NO-Mediated GABA Release by Reactive Oxygen Species in the Rostral Ventrolateral Medulla Results in Sympathoexcitation in Hypertensive Rats (2011)
  • 著者名/発表者名: Shinohara K, et al
  • 学会等名: Scientific Sessions 2011, American Heart Association
  • 発表場所: Orland,U.S.A.
  • 年月日: 2011-11-14
• [学会発表] Vagus Nerve Stimulation in Heart Failure (2011)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: ISAN/AAS-2011 Satellite Meeting
  • 発表場所: Buzios, Brazil(招待講演)
  • 年月日: 2011-09-17
• [学会発表] Bionic Baroreflex Control of Blood Pressure in Hypotensive & Hypertensive Disorders (2011)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: ISAN/AAS-2011 Satellite Meeting
  • 発表場所: Buzios, Brazil(招待講演)
  • 年月日: 2011-09-17
• [学会発表] What the vagal nerve stimulation can do for the diseased heart? (2011)
  • 著者名/発表者名: Sunagawa K
  • 学会等名: 7^<th> Congress of the International Society for Autonomic Neuroscience : ISAN, 22^<nd> Symposium of the American Autonomic Society
  • 発表場所: Buzios, Brazil(招待講演)
  • 年月日: 2011-09-16
• [学会発表] Autoimplantation of astrocytes into cardiovascular center of brainstem causes sympathoinhibition and decreases the mortality rate in hypertensive rats (2011)
  • 著者名/発表者名: Kishi T, Sunagawa K
  • 学会等名: 7^<th> Congress of the International Society for Autonomic Neuroscience : ISAN, 22^<nd> Symposium of the American Autonomic Society
  • 発表場所: Buzios, Brazil
  • 年月日: 2011-09-14
• [学会発表] Baroreflex changes only stressed volume not the slope of the venous return surface in anesthetized dogs (2011)
  • 著者名/発表者名: Sakamoto T, et al
  • 学会等名: 7^<th> Congress of the International Society for Autonomic Neuroscience : ISAN, 22^<nd> Symposium of the American Autonomic Society
  • 発表場所: Buzios, Brazil
  • 年月日: 2011-09-13
• [学会発表] Impact of Baroreflex on Venous Return Surface (2011)
  • 著者名/発表者名: Sakamoto T, et al
  • 学会等名: 33^<rd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Boston, U.S.A.
  • 年月日: 2011-09-01
• [学会発表] Artificial Baroreflex System Restores Volume Tolerance in the Absence of Native Baroreflex (2011)
  • 著者名/発表者名: Hosokawa K, et al
  • 学会等名: 33^<rd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Boston, U.S.A.
  • 年月日: 2011-08-31
• [学会発表] Experimental Jet Lag Causes Sympathoexcitation via Oxidative Stress through AT1 Receptor in the Brainstem (2011)
  • 著者名/発表者名: Kishi T, et al
  • 学会等名: 33^<rd> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 発表場所: Boston, U.S.A.
  • 年月日: 2011-08-31
• [産業財産権] 動脈厚反射機能障害に関連した疾患を治療するためのバイオニック動脈圧反射システム (2011)
  • 発明者名: 砂川賢二, 他
  • 権利者名: 九州大学
  • 出願年月日: 2011-09-21
  • 外国