変形性関節症の重症度定量的評価の確立および危険因子の解明：日英米国際共同研究

• 研究課題/領域番号: 23390356
• 研究種目: 基盤研究(B)
• 配分区分: 補助金
• 応募区分: 一般
• 研究分野: 整形外科学
• 研究機関: 東京大学
• 研究代表者: 村木 重之 東京大学, 医学部附属病院, 准教授 (40401070)
• 研究分担者: 吉村 典子 東京大学, 医学部附属病院, 特任准教授 (60240355) ; 阿久根 徹 , 国立障害者リハビリテーションセンター, 副院長 (60282662) ; 岡 敬之 東京大学, 医学部附属病院, 特任助教 (60401064)
• 研究期間 (年度): 2011-04-01 – 2015-03-31
• 研究課題ステータス: 完了 (2014年度)
• 配分額: 15,990千円 (直接経費: 12,300千円、間接経費: 3,690千円); 2013年度: 3,900千円 (直接経費: 3,000千円、間接経費: 900千円); 2012年度: 4,160千円 (直接経費: 3,200千円、間接経費: 960千円); 2011年度: 7,930千円 (直接経費: 6,100千円、間接経費: 1,830千円)
• キーワード: コホート / 医療・福祉 / 老化 / 疫学 / 国際比較 / 医療福祉 / ゲノム

研究成果の概要

われわれは膝、腰椎、股関節の関節裂隙、骨棘、その他OA 指標を定量化する自動定量システムを開発し、厳密なOA の国際比較を可能とした。本研究では、日本The ROAD Study（3,040例）, 英国The Chingford Study（1,353例）のコホート研究による国際共同研究を行い、膝、腰椎、股関節における関節裂隙幅、骨棘形成、その他OA 指標の基準値の確立及び人種間差の解明を行うとともに、特に男性において膝関節裂隙狭小化だけでなく骨棘形成もADL, QOLにおおきな影響を与えていること、さらには栄養状態や職業活動歴が膝関節裂隙狭小化や骨棘形成と有意な関連があることを明らかにした。

研究成果

• [雑誌論文] Association of Dietary Intake with Joint Space Narrowing and Osteophytosis at the Knee in Japanese Men and Women: The ROAD Study (2014)
  • 著者名/発表者名: Muraki S, Akune T, En-yo Y, Yoshida M, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
  • 雑誌名: Modern Rheum 巻: in press
  • 査読あり
• [雑誌論文] Prevalence and progression of the radiographic ossification of posterior longitudinal ligament and its associated factors in the Japanese populations: A 3-year follow-up of the ROAD study. (2014)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: Osteoporos Int 巻: 24 ページ: 1089-1098
  • DOI: 10.1007/s00198-013-2372-z
  • 査読あり / オープンアクセスとしている / 謝辞記載あり
• [雑誌論文] Prevalence, Incidence, and Progression of Lumbar Spondylosis by Gender and Age Strata (2014)
  • 著者名/発表者名: Muraki S, Yoshimura N, Akune T, Sakae Tanaka, Ikuno Takahashi, Saeko Fujiwara.
  • 雑誌名: Modern Rheum 巻: in press
  • 査読あり
• [雑誌論文] Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study. (2014)
  • 著者名/発表者名: Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
  • 雑誌名: Osteoporos Int 巻: 25 ページ: 1089-1098
  • DOI: 10.1007/s00198-013-2489-0
  • 査読あり / 謝辞記載あり
• [雑誌論文] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study (2014)
  • 著者名/発表者名: Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N.
  • 雑誌名: Geriatr Gerontol Int 巻: in press ページ: 695-701
  • DOI: 10.1111/ggi.12155
  • 査読あり / オープンアクセスとしている / 謝辞記載あり
• [雑誌論文] Prevalence of knee pain, lumbar pain and its co-existence in Japanese men and women: The LOCOMO (Longitudinal Cohorts of Motor System Organ) study. (2014)
  • 著者名/発表者名: Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
  • 雑誌名: J Bone Miner Metab. 巻: in press
  • 査読あり
• [雑誌論文] Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study (2014)
  • 著者名/発表者名: Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • 雑誌名: Osteoporos Int 巻: 25 ページ: 1081-1088
  • DOI: 10.1007/s00198-013-2550-z
  • 査読あり / オープンアクセスとしている / 謝辞記載あり
• [雑誌論文] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study (2014)
  • 著者名/発表者名: Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • 雑誌名: Osteoarthritis and Cartilage 巻: 22 ページ: 104-10
  • DOI: 10.1016/j.joca.2013.10.019
  • 査読あり / 謝辞記載あり
• [雑誌論文] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: The ROAD Study (2014)
  • 著者名/発表者名: Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N.
  • 雑誌名: Modern Rheum 巻: in press
  • 査読あり
• [雑誌論文] Association of physical activities of daily living with the incidence of certified need of care in the long-term care insurance system of Japan: the ROAD study. (2014)
  • 著者名/発表者名: Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • 雑誌名: J Orthop Sci 巻: in press
  • 査読あり
• [雑誌論文] Incidence of disability and its associated factors in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study (2014)
  • 著者名/発表者名: Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
  • 雑誌名: J Bone Miner Metab. 巻: in press
  • 査読あり
• [雑誌論文] Prevalence of diffuse idiopathic skeletal hyperostosis of the whole spine and its association with knee osteoarthritis: the ROAD study. (2014)
  • 著者名/発表者名: Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata1 K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • 雑誌名: J Bone Miner Metab. 巻: in press
  • 査読あり
• [雑誌論文] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based magnetic resonance imaging study: the Wakayama Spine Study (2014)
  • 著者名/発表者名: 52. Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • 雑誌名: Spine J 巻: in press ページ: 2811-2817
  • DOI: 10.1016/j.spinee.2014.03.051
  • 査読あり / オープンアクセスとしている / 謝辞記載あり
• [雑誌論文] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women: A longitudinal cohort study (2013)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Osteoporos Int 巻: 21(Epub ahead of print) ページ: 459-466
  • DOI: 10.1007/s00198-012-1967-0
  • 査読あり
• [雑誌論文] Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study. (2013)
  • 著者名/発表者名: Muraki S
  • 雑誌名: BMJ Open 巻: 52 ページ: 516-23
  • DOI: 10.1016/j.bone.2012.10.020
  • 査読あり
• [雑誌論文] The mid-term efficacy of intra-articular hyaluronic acid injections on joint structure: a nested case control study. (2013)
  • 著者名/発表者名: Oka H, Akune T, Muraki S, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N.
  • 雑誌名: Mod Rheumatol 巻: 23 ページ: 722-728
  • DOI: 10.1007/s10165-012-0725-7
  • NAID: 10031189167
  • 査読あり
• [雑誌論文] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the WakayamaSpine Study (2013)
  • 著者名/発表者名: Ishimoto Y
  • 雑誌名: Osteoarthritis Cartilage 巻: 印刷中 ページ: 783-788
  • DOI: 10.1016/j.joca.2013.02.656
  • 査読あり
• [雑誌論文] Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan: the Wakayama Spine Study. (2012)
  • 著者名/発表者名: Ishimoto Y
  • 雑誌名: Osteoarthritis Cartilage 巻: 20 ページ: 11-11
  • 査読あり
• [雑誌論文] Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan: the Wakayama spine study. (2012)
  • 著者名/発表者名: Nagata K
  • 雑誌名: Spine (Phila Pa 1976) 巻: 37 ページ: 1892-1898
  • 査読あり
• [雑誌論文] Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: A longitudinal population-based cohort study. (2012)
  • 著者名/発表者名: Muraki S
  • 雑誌名: Arthritis Rheum 巻: 64 ページ: 1447-1456
  • 査読あり
• [雑誌論文] Incidence and risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women: the ROAD study. (2012)
  • 著者名/発表者名: Muraki S
  • 雑誌名: Osteoarthritis Cartilage 巻: 20 ページ: 712-718
  • 査読あり
• [雑誌論文] Prevalence of vertebral fracture in Asian men and women: Comparison between Hong Kong, Thailand, Indonesia and Japan. (2012)
  • 著者名/発表者名: Kwok K
  • 雑誌名: Public Health 巻: 126 ページ: 523-531
  • 査読あり
• [雑誌論文] Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study. (2012)
  • 著者名/発表者名: Yoshimura N
  • 雑誌名: BMJ Open 巻: 2
  • 査読あり
• [雑誌論文] Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: The ROAD Study. (2012)
  • 著者名/発表者名: Muraki S
  • 雑誌名: Bone 巻: 52 ページ: 516-523
  • 査読あり
• [雑誌論文] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women: a longitudinal cohort study. (2012)
  • 著者名/発表者名: Muraki S
  • 雑誌名: Osteoporos Int 巻: 24 ページ: 459-466
  • 査読あり
• [雑誌論文] Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men : the ROAD study (2011)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Enyo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Spine (Phila Pa 1976) 巻: 36 ページ: 1312-1319
  • 査読あり
• [雑誌論文] Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee : the ROAD study (2011)
  • 著者名/発表者名: Muraki S, Oka H, Akune T, Enyo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Osteoarthritis Cartilage 巻: 19 ページ: 840-846
  • 査読あり
• [雑誌論文] Association of vitamin D status with knee pain and radiographic knee osteoarthritis (2011)
  • 著者名/発表者名: Muraki S, Dennison E, Jameson K, Boucher BJ, Akune T, Yoshimura N, Judge A, Arden NK, Javaid K, Cooper C
  • 雑誌名: Osteoarthritis Cartilage 巻: 19 ページ: 1301-1306
  • 査読あり
• [雑誌論文] Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan : A cross-sectional study (2011)
  • 著者名/発表者名: Muraki S, Oka H, Akune T, EnYo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Arthritis Rheum 巻: 63 ページ: 3859-3864
  • 査読あり
• [雑誌論文] Prevalence of falls and its association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women (2011)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, EnYo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Arthritis Care Res (Hoboken) 巻: 63 ページ: 1425-1431
  • 査読あり
• [雑誌論文] Changes in serum levels of biochemical markers of bone turnover over 10 years among Japanese men and women : associated factors and birth-cohort effect ; the Taiji study (2011)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: J Bone Miner Metab 巻: 29 ページ: 699-708
  • 査読あり
• [雑誌論文] Biochemical markers of bone turnover as predictors for occurrence of osteoporosis and osteoporotic fractures in men and women : Ten-year follow-up of the Taiji cohort study (2011)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: Mod Rheumatol 巻: 21 ページ: 608-620
  • 査読あり
• [雑誌論文] Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability : The second survey of the ROAD study (2011)
  • 著者名/発表者名: Yoshimura N, Oka H, Muraki S, Akune T, Hirabayashi N, Matsuda S, Nojiri T, Hatanaka K, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Kawaguchi H, Nakamura K
  • 雑誌名: J Orthop Sci 巻: 16 ページ: 768-777
  • 査読あり
• [雑誌論文] Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women : the ROAD study (2011)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: J Rheumatol 巻: 38 ページ: 921-930
  • 査読あり
• [雑誌論文] Capacity of endogenous sex steroids to predict bone loss in Japanese men : 10-year follow-up of the Taiji Cohort Study (2011)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 雑誌名: J Bone Miner Metab 巻: 29 ページ: 96-102
  • NAID: 10029023846
  • 査読あり
• [雑誌論文] Incidence and Risk Factors for Radiographic Knee Osteoarthritis and Knee Pain in Japanese Men and Women : a Longitudinal Population-Based Cohort Study
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Arthritis Rheum 巻: (In press)
  • 査読あり
• [雑誌論文] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and Women : A Longitudinal Cohort Study
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • 雑誌名: Osteoporos Int 巻: (In press)
  • 査読あり
• [雑誌論文] The Prevalence of Vertebral Fracture in Asian Men and Women : Comparison between Hong Kong, Thailand, Indonesia and Japan
  • 著者名/発表者名: Kwok A, Leung J, Chan A, Au B, Lau E, Yurianto H, Yuktanandana P, Yoshimura N, Muraki S, Oka H, Akune T, Leung P
  • 雑誌名: Public Health 巻: (In press)
  • 査読あり
• [学会発表] 変形性膝関節症の定量評価：The ROAD Study (2014)
  • 著者名/発表者名: 村木重之
  • 学会等名: 膝OAと運動・装具療法セミナー
  • 発表場所: 福岡
  • 招待講演
• [学会発表] Higher levels of serum 25(OH)D prevents the occurrence of osteoporosis, but deteriorates knee osteoarthritis: The ROAD study (2013)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Nakamura K, Tanaka S, Kawaguchi H, Akune T
  • 学会等名: IOF
  • 発表場所: Rome, Italy
• [学会発表] The Incidence Rate and Risk Factors for Radiographic Knee Osteoarthritis and Knee Pain: The ROAD Study (2013)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • 学会等名: IOF
  • 発表場所: Rome, Italy
• [学会発表] Association of diffuse idiopathic skeletal hyperostosis and bone mineral density and marker of bone metabolism: the ROAD study (2013)
  • 著者名/発表者名: Kagotani R, Muraki S, Oka H, Yoshida M, Hashizume H, Yamada H, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • 学会等名: IOF
  • 発表場所: Rome, Italy
• [学会発表] Risk Factors for Multiple Falls in Japanese Men and Women: The ROAD Study. (2013)
  • 著者名/発表者名: Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • 学会等名: 2nd Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR)
  • 発表場所: Kobe, Japan
• [学会発表] Prevalence of sarcopenia and its association with exercise habits in middle age and physical performance in the elderly participants of Japanese population-based cohorts: the ROAD study (2013)
  • 著者名/発表者名: Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • 学会等名: IOF regionals
  • 発表場所: Hong Kong, China
• [学会発表] 大規模縦断研究による変形性膝関節症の疫学 (2013)
  • 著者名/発表者名: 村木重之
  • 学会等名: 膝OAと運動・装具療法セミナー
  • 発表場所: 神戸
  • 招待講演
• [学会発表] 変形性股関節症の有病率および股関節痛との関連 ―The ROAD Studyー (2013)
  • 著者名/発表者名: 村木重之
  • 学会等名: 日本股関節学会
  • 発表場所: 広島
  • 招待講演
• [学会発表] Accumulation of metabolic risk factors raises the risk of occurrence and progression of knee osteoarthritis: the ROAD study. (2012)
  • 著者名/発表者名: Yoshimura N
  • 学会等名: Annual European Congress of Rheumatology (EULAR)
  • 発表場所: Berlin, Germany
• [学会発表] Mild Cognitive Impairment Increases The Risk of Knee Osteoarthritis: A 3-Year Follow-Up in The ROAD Study. (2012)
  • 著者名/発表者名: Yoshimura N
  • 学会等名: IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting
  • 発表場所: Kuala Lumpur, Malaysia
• [学会発表] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and women: The ROAD Study. (2012)
  • 著者名/発表者名: Muraki S
  • 学会等名: IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting
  • 発表場所: Kuala Lumpur, Malaysia
• [学会発表] 変形性膝関節症の発生率及びその危険因子 ―The ROAD Study― (2012)
  • 著者名/発表者名: 村木重之
  • 学会等名: 第85回日本整形外科学会
  • 発表場所: 京都
• [学会発表] 変形性関節症の疫学 The ROAD Study (2012)
  • 著者名/発表者名: 村木重之
  • 学会等名: 日本関節病学会
  • 発表場所: 鹿児島
  • 招待講演
• [学会発表] The prevalence of lumbar spinal stenosis using mobile MRI in local inhabitants : The ROAD-MRI study (2012)
  • 著者名/発表者名: Ishimoto Y, Yamada H, Nagata K, Hashizume H, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
  • 学会等名: AAOS
  • 発表場所: San Francisco, USA
• [学会発表] The Prevalence Of Cervical Cord Compression Using Mobile MRI In Local Inhabitants : The Road-MRI Study (2012)
  • 著者名/発表者名: Nagata K, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
  • 学会等名: AAOS
  • 発表場所: San Francisco, USA
• [学会発表] Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose intolerance raises the risk of occurence and progression of knee osteooarthritis : A 3-year follow-up of the ROAD Study (2012)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 学会等名: IOF-ECCEO
  • 発表場所: Bordeaux, France
• [学会発表] Prevalence of cervical cord compression and its relations to physical signs and performances in a Japanese population-based cohort : The ROAD-MRI Study (2011)
  • 著者名/発表者名: Nagata K, Yoshida M, Hashizume H, Yamada H, Ishimoto Y, Takiguchi N, Muraki S, Oka H, Akune T, Yoshimura N
  • 学会等名: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • 発表場所: Gifu, Japan
• [学会発表] The prevalence of lumbar spinal stenosis using MRI in a local cohort : The ROAD-MRI Study (2011)
  • 著者名/発表者名: Ishimoto Y, Yamada H, Hashizume H, Nagata K, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
  • 学会等名: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • 発表場所: Gifu, Japan
• [学会発表] The Prevalence of the lumbar spinal stenosis with Mobile MRI in a population-based cohort : The Road-MRI Study (2011)
  • 著者名/発表者名: Ishimoto Y, Yoshida M, Yamada H, Nagata K, Hashizume H, Takiguchi N, Shigeyuki M, Oka H, Akune T, Yoshimura N
  • 学会等名: Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS)
  • 発表場所: Gothenburg, Sweden
• [学会発表] Role of neuro muscular function in predicting the occurrence of disability : The ROAD study (2011)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 学会等名: IEA World Congress of Epidemiology
  • 発表場所: Edinburgh, Scotland
• [学会発表] Vitamin D insufficiency and deficiency as a risk factor for fast bone loss among elderly men and women : The ROAD study (2011)
  • 著者名/発表者名: Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 学会等名: The 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • 発表場所: Gold Coast, Australia
• [学会発表] Risk factors for multiple falls in a longitudinal population-based cohort study in Japan : the ROAD study (2011)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: The 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • 発表場所: Gold Coast, Australia
• [学会発表] Risk factors for the incidence and progress rate of radiographic knee osteoarthritis in Japanese men and women : the ROAD study (2011)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: Osteoarthritis Research Society International (OARSI) 2011 World Congress on Osteoarthritis
  • 発表場所: San Diego, USA
• [学会発表] Vitamin D Insufficiency and Occurrence of Osteoporosis and Disability : the ROAD study (2011)
  • 著者名/発表者名: Yoshimura N, Muraki M, Oka H, Kawaguchi H, Nakamura K, Akune T
  • 学会等名: The 33rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: San Diego, USA
• [学会発表] Incidence of multiple falls and risk factors in a longitudinal population-based cohort study in Japan : the ROAD study (2011)
  • 著者名/発表者名: Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • 学会等名: The 33rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • 発表場所: San Diego, USA
• [学会発表] Prevalence of cervical cord compression and its association with physical performance in a large population-based cohort : The ROAD-MRI Study (2011)
  • 著者名/発表者名: Nagata K, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
  • 学会等名: CSRS
  • 発表場所: Arizona, USA