交互脈の発生に関する数理モデルおよび動物モデルを用いた抑制方法の開発

• 研究課題/領域番号: 23500524
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 医用生体工学・生体材料学
• 研究機関: 首都大学東京
• 研究代表者: 矢澤 徹 首都大学東京, 理工学研究科, 助教 (30106603)
• 研究期間 (年度): 2011 – 2013
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 5,200千円 (直接経費: 4,000千円、間接経費: 1,200千円); 2013年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2012年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円); 2011年度: 2,600千円 (直接経費: 2,000千円、間接経費: 600千円)
• キーワード: 交互脈 / Alternans / 高カリウム / モデル / 心臓 / 不整脈 / イオン / 数理モデル / 生理学実験 / 甲殻類 / 動物モデル

研究概要

交互脈は死の予兆と言われる不整脈の1つで虚血性心疾患などで有名である。この不都合な脈が北島数理モデルで出せるか、条件を探った。イオンの血中濃度、組織液濃度、そして細胞内濃度のバランスが直接の因子と想定しシミュレーション実験をした。数理モデルには、私の研究したエビ心臓電位波形が使われており、2周期が出せる。各イオンを標準値から増減させる実験結果は意外であった。筋収縮にとって肝心要のイオンであるカルシウムより大量にある塩（しお）特にカリウムK＋の濃さの変化だけで交互脈が発生することを突き止めた。K+という塩分でも交互脈が発生しうることを突き止めた。抑制はKからである。

研究成果

• [雑誌論文] Alternans-Arrhythmia: A Simulation Study Based on Invertebrate Heart Neurobiology (2014)
  • 著者名/発表者名: Yazawa, T., and Kitajima, H
  • 雑誌名: Proceedings IMCIC2014 ページ: 184-189
• [雑誌論文] Alternans-Arrhythmia: A Simulation Study Based on Invertebrate Heart Neurobiology. (2014)
  • 著者名/発表者名: Yazawa, T., and Kitajima, H.
  • 雑誌名: Proceedings IMCIC2014 巻: - ページ: 184-189
  • 査読あり
• [雑誌論文] A Simulation Study of Alternans-Arrhythmia Based on Physiology of Invertebrate Heart (2013)
  • 著者名/発表者名: Yazawa, T., and Kitajima, H., and Shimizu, A
  • 雑誌名: Proceedings of The World Congress on Engineering and Computer Science 2013 ページ: 604-609
• [雑誌論文] Measurement of Stress Using DFA Heartbeat Analysis (2013)
  • 著者名/発表者名: Yazawa, T., Hutapea, A. M., Otomura, Y., Sagawa, K., Yamada, Y., Suzuki, T., and Katsuyama, T
  • 雑誌名: Proceedings of The World Congress on Engineering and Computer Science 2013 ページ: 596-603
• [雑誌論文] DFA of Cardiac and Psychological Abnormality: A Test of Quantification Method on Models and Humans. (2013)
  • 著者名/発表者名: Yazawa, T., Hutapea, A. M., Shimoda, Y., Otomura, Y., Sagawa, K., Yamada, Y., and Suzuki, T.
  • 雑誌名: Proceedings of The 17th World Multi-Conference on Systemics, Cybernetics and Informatics 巻: - ページ: 58-63
  • 査読あり
• [雑誌論文] Measurement of Stress Using DFA Heartbeat Analysis. (2013)
  • 著者名/発表者名: Yazawa, T., Hutapea, A. M., Otomura, Y., Sagawa, K., Yamada, Y., Suzuki, T., and Katsuyama, T.
  • 雑誌名: Proceedings of The World Congress on Engineering and Computer Science 2013 巻: - ページ: 596-603
  • 査読あり
• [雑誌論文] A Simulation Study of Alternans-Arrhythmia Based on Physiology of Invertebrate Heart. (2013)
  • 著者名/発表者名: Yazawa, T., and Kitajima, H., and Shimizu, A.
  • 雑誌名: Proceedings of The World Congress on Engineering and Computer Science 2013 巻: - ページ: 604-609
  • 査読あり
• [雑誌論文] Athlete heartbeats engaged in ergometer exercise: A detrended fluctuation analysis checking the heart rhythm condition (2012)
  • 著者名/発表者名: Yazawa, T., Hutapea, A., and Shimoda, Y
  • 雑誌名: Engineering Letters 巻: Vol. 20 ページ: 10-15
• [雑誌論文] Cardiac rhythm reflects mental condition as in chronic job stress: A detrended fluctuation analysis (2012)
  • 著者名/発表者名: Hutapea, A. M., and Yazawa, T
  • 雑誌名: Proceedings, Fall 2012 IIIS Conference 巻: 1 ページ: 201-206
• [雑誌論文] Time Series Analysis of Heartbeat-Interval at the Subjects Ranging from Crustacean Animal to Human (2012)
  • 著者名/発表者名: Yazawa, T., and Katsuyama, T
  • 雑誌名: Proceedings ページ: 94-99
• [雑誌論文] Neurodynamical control of the heart of freely moving animals including humans. Proceedings (2012)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., Shimizu, S., and Katsuyama, T
  • 雑誌名: ASME 2012 ページ: 1-10
• [雑誌論文] DFA Applied to the Neural-Regulation of the Heart (2012)
  • 著者名/発表者名: Yazawa, T., and Shimoda, Y
  • 雑誌名: Proceedings 巻: 2 ページ: 715-720
• [雑誌論文] Athlete heartbeats engaged in ergometer exercise: A detrended fluctuation analysis checking the heart rhythm condition. (2012)
  • 著者名/発表者名: Yazawa, T., Hutapea, A. M., Shimoda, Y.
  • 雑誌名: Engineering Letters 巻: 20 ページ: 10-15
  • 査読あり
• [雑誌論文] Neurodynamical control of the heart of freely moving animals including humans. (2012)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., Shimizu, S., Katsuyama, T.
  • 雑誌名: ASME 2012 Proceedings, 論文番号IMECE2012-85872 巻: I ページ: 1-10
• [雑誌論文] Time Series Analysis of Heartbeat-Interval at the Subjects Ranging from Crustacean Animal to Human (2012)
  • 著者名/発表者名: Yazawa, T., Katsuyama, T.,
  • 雑誌名: IIIS-IMETI2012 Proceedings 巻: I ページ: 94-99
• [雑誌論文] DFA Applied to the Neural-Regulation of the Heart. (2012)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y.
  • 雑誌名: WCECS- ICCB_14 Proceedings 巻: II ページ: 715-720
• [雑誌論文] Athlete Heartbeats Engaged in Ergometer Exercise: A Detrended Fluctuation Analysis Checking the Heart Rhythm Condition (2012)
  • 著者名/発表者名: Toru Yazawa, Albert M. Hutapea, and Yukio Shimoda
  • 雑誌名: Engineering Letters 巻: 20 ページ: 10-15
  • 査読あり
• [雑誌論文] Analysis of a cardiac mathematical model for suppressing alternans (2011)
  • 著者名/発表者名: Kitajima, H., and Yazawa, T
  • 雑誌名: IEICE Technical Report ページ: 61-64
• [雑誌論文] Detrended fluctuation analysis of arrhythmia: Scaling exponent as an index of heart wellness (2011)
  • 著者名/発表者名: Yazawa, T., Hutapea, A., Katsuyama, T., and Shimoda, Y
  • 雑誌名: Proceedings ASME2011 ページ: 10-10
• [雑誌論文] Quantification of athlete's heartbeats engaged in ergometer exercise: A detrended fluctuation analysis study checking the heart condition (2011)
  • 著者名/発表者名: Yazawa, T., Hutapea, A., and Shimoda, Y
  • 雑誌名: Proceedings WCECS2011 巻: Vol. 2 ページ: 585-590
• [雑誌論文] Quantification of Athlete’s Heartbeats Engaged in Ergometer Exercise: A Detrended Fluctuation Analysis Study Checking the Heart Condition (2011)
  • 著者名/発表者名: Toru Yazawa, Albert M. Hutapea, and Yukio Shimoda
  • 雑誌名: WCECS2011 巻: 2 ページ: 585-590
  • 査読あり
• [雑誌論文] Detrended Fluctuation Analysis of Arrhythmia: Scaling Exponent as an Index of Heart Wellness (2011)
  • 著者名/発表者名: Toru Yazawa, Albert M. Hutaapea, Tomoo Katsuyama, and Yukio Shimoda
  • 雑誌名: ASME2011 巻: Proceedings ページ: 1-10
  • 査読あり
• [学会発表] Alternans-Arrhythmia : A Simulation Study Based on Invertebrate Heart Neurobiology (2014)
  • 著者名/発表者名: Yazawa, T., and Kitajima. H
  • 学会等名: The International Multi-Conference On Complexity And Cybernetics
  • 発表場所: Orlando, FL, USA
• [学会発表] 招待講演 心臓はこころを映し出す窓２ (2014)
  • 著者名/発表者名: 矢澤徹
  • 学会等名: DVx Inc.
  • 発表場所: 東京
  • 招待講演
• [学会発表] A Simulation Study of Alternans-Arrhythmia Based on Physiology of Invertebrate Heart (2013)
  • 著者名/発表者名: Yazawa, T., Kitajima. H., and Shimizu, A
  • 学会等名: Proceedings of The World Congress on Engineering and Computer Science 2013
  • 発表場所: UC Berkeley, CA, USA
• [学会発表] Measurements of stress by heartbeat analysis : an empirical work of DFA both in animal models and humans (2013)
  • 著者名/発表者名: Yazawa, T
  • 学会等名: 23rd Annual Conference Society for Chaos Theory in Psychology & Life Sciences
  • 発表場所: Portland State University, Portland, Oregon, USA
• [学会発表] Measurements of stress by heartbeat analysis: an empirical work of DFA both in animal models and humans. (2013)
  • 著者名/発表者名: Yazawa, T.
  • 学会等名: 23rd Annual Conference Society for Chaos Theory in Psychology & Life Sciences.
  • 発表場所: Portland State University, Portland, Oregon, USA
• [学会発表] ストレス・不安を数値判定する心拍ゆらぎ解析法の開発. (2013)
  • 著者名/発表者名: 矢澤徹
  • 学会等名: イノベーションジャパン.
  • 発表場所: 東京
• [学会発表] Neurodynamical control of the heart of freely moving animals including humans (2012)
  • 著者名/発表者名: Yazawa, T
  • 学会等名: International Mechanical Engineering Congress & Exposition ASME 2012.
  • 発表場所: Houston, Texas, USA
• [学会発表] DFA Applied to the Neural-Regulation of the Heart (2012)
  • 著者名/発表者名: Yazawa, T
  • 学会等名: WCECS2012
  • 発表場所: UC Berkely, CA, USA
• [学会発表] Neurodynamical control of the heart of freely moving animals including humans. (2012)
  • 著者名/発表者名: Toru Yazawa
  • 学会等名: ASME２０１２
  • 発表場所: Houston, TX, USA
• [学会発表] DFA Applied to the Neural-Regulation of the Heart. (2012)
  • 著者名/発表者名: Toru Yazawa
  • 学会等名: WCECS2012
  • 発表場所: UC Berkeley, CA, USA
• [学会発表] Time series analysis of heartbeat-interval at the subjects ranging from crustacean animal to human. (2012)
  • 著者名/発表者名: Toru Yazawa
  • 学会等名: 5TH Int. Conf. Engeering, Technology and Innovation.
  • 発表場所: Orlando, FL. USA
• [学会発表] Scaling Exponent During Arrhythmia : Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool (2011)
  • 著者名/発表者名: Yazawa, T
  • 学会等名: International Mechanical Engineering Congress & Exposition ASME 2011
  • 発表場所: Denver, Colorado, USA
  • 年月日: 2011-11-16
• [学会発表] Quantification of Athlete's Heartbeats Engaged in Ergometer Exercise : A Detrended Fluctuation Analysis Study Checking the Heart Condition (2011)
  • 著者名/発表者名: Yazawa, T
  • 学会等名: International Conference on Computational Biology 2011
  • 発表場所: San Francisco, CA, USA
  • 年月日: 2011-10-21
• [学会発表] Detrended Fluctuation Analysis of Heartbeats While Engaging in Ergometer Exercise : Checking the Heart Condition by Numerical Quantification Method (2011)
  • 著者名/発表者名: Yazawa, T
  • 学会等名: The 5th International Symposium on Bio- and Medical Informatics and Cybernetics (BMIC 2011)
  • 発表場所: Orlando, FL, USA
  • 年月日: 2011-07-20
• [学会発表] 突然の心停止の予知：心電図の状態空間イメージング (2011)
  • 著者名/発表者名: 矢澤徹、霜田幸雄
  • 学会等名: 第20回日本バイオイメージング学会学術集会
  • 発表場所: 千歳
• [学会発表] Detrended Fluctuation Analysis of Heartbeats While Engaging in Ergometer Exercise: Checking the Heart Condition by Numerical Quantification Method (2011)
  • 著者名/発表者名: Toru Yazawa
  • 学会等名: The 5th International Symposium on Bio- and Medical Informatics and Cybernetics (BMIC 2011)
  • 発表場所: Orlando, FL, USA
• [学会発表] Quantification of Athlete's Heartbeats Engaged in Ergometer Exercise: A Detrended Fluctuation Analysis Study Checking the Heart Condition (2011)
  • 著者名/発表者名: Toru Yazawa
  • 学会等名: International Conference on Computational Biology 2011
  • 発表場所: San Francisco, CA, USA
• [学会発表] Scaling Exponent During Arrhythmia: Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool (2011)
  • 著者名/発表者名: Toru Yazawa
  • 学会等名: ASME 2011 International Mechanical Engineering Congress & Exposition
  • 発表場所: Denver, Colorado, USA
• [学会発表] Quantification of stress by fluctuation analysis of heartbeat-interval time series.
  • 著者名/発表者名: Toru Yazawa
  • 学会等名: sfn アメリカ北米神経科学学会
  • 発表場所: New Orleans, USA
• [学会発表] 心臓はこころを映し出す窓
  • 著者名/発表者名: 矢澤徹
  • 学会等名: DVX Inc.
  • 発表場所: 東京
  • 招待講演
• [図書] Detrended Fluctuation Analysis : An Experiment about the Neural-Regulation of the Herat and Motor Vibration. IAENG Transactions on Engineering Technologies (2014)
  • 著者名/発表者名: Yazawa, T., and Shimoda, Y
  • 出版者: Springer Science+Business Media Dordrecht 2013(in press)
• [図書] Quantification of Athlete's Heart Condition : A Detrended Fluctuation Analysis. In: IAENG Transactions on Engineering Technologies, Lecture Notes in Electrical Engineering (2013)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., and Hutapea, A. M
  • 出版者: Springer Science +Business Media Dordrecht
• [図書] IAENG Transactions on Engineering Technologies, Lecture Notes in Electrical Engineering. Volume 170, Book Chapter 25, Quantification of Athlete’s Heart Condition: A Detrended Fluctuation Analysis. (2013)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., and Hutapea, A. M.
  • 総ページ数: 14
  • 出版者: Springer Science +Business Media Dordrecht.
• [図書] Chap 20, Quantification of athlete’s heart condition: Detrended fluctuation analysis. IAENG Transactions on Engineering Technologies - Special Edition (2012)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., Hutapea, A. M.
  • 総ページ数: 15
  • 出版者: Springer, New York.
• [図書] DFA, a biomedical checking tool for the heart control system. In : Machine Learning and Systems Engineering (2011)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., and Katsuyama, T
• [図書] Low Scaling Exponent during Arrhythmia : Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool. In: Biomedical Engineering, Trends, Research and Technologies, Malgorzata Anna Komorowska and Sylwia Olsztynska-Janus (Eds.) (2011)
  • 著者名/発表者名: Yazawa, T., and Shimoda, Y
  • 出版者: InTech
• [図書] EVALUATION OF SLEEP BY DETRENDED FLUCTUATION ANALYSIS OF THE HEARTBEAT. In : IAENG Transactions on Engineering Technologies. S-L. Ao (Ed.) (2011)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., and Hutapea, A
  • 出版者: American Institute of Physics, AIP Book
• [図書] Biomedical Engineering, Trends, Research and Technologies (2011)
  • 著者名/発表者名: Toru Yazawa and Yukio Shimoda
  • 出版者: Low Scaling Exponent during Arrhythmia: Detrended Fluctuation Analysis is a Beneficial Biomedical Computation Tool
• [図書] IAENG Trans actions on Engineering Technologies (2011)
  • 著者名/発表者名: Toru Yazawa , Yukio Shimoda and Albert M. Hutapea
  • 出版者: EVALUATION OF SLEEP BY DETRENDED FLUCTUATION ANALYSIS OF THE HEARTBEAT
• [図書] Machine Learnig and Systems Engineering (2011)
  • 著者名/発表者名: Yazawa, T., Shimoda, Y., Katsuyama, T.
  • 出版者: DFA, a biomedical checking tool for the heart control system
• [備考]
  • URL: http://www.tokyo-sangaku.jp/labo/%E7%9F%A2%E6%BE%A4-%E5%BE%B9/
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