ＰＫ／ＰＤ理論と標的臓器の治療目標達成確率を指標とした抗菌剤の最適投与法の確立

• 研究課題/領域番号: 23590184
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 医療系薬学
• 研究機関: 広島大学
• 研究代表者: 森川 則文 広島大学, 医歯薬保健学研究院(薬), 教授 (30346481)
• 研究分担者: 猪川 和朗 広島大学, 大学院医歯薬保健学研究院 (薬), 准教授 (40363048) ; 池田 佳代 広島大学, 大学院医歯薬保健学研究院 (薬), 助教 (30379911)
• 研究期間 (年度): 2011 – 2013
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 5,460千円 (直接経費: 4,200千円、間接経費: 1,260千円); 2013年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2012年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2011年度: 3,380千円 (直接経費: 2,600千円、間接経費: 780千円)
• キーワード: 薬物動態 / 抗菌剤 / ＰＫ／ＰＤ理論 / 医療系薬学 / 日本 / 臨床 / 感染症 / PK/PD

研究概要

我々は、ヒト前立腺組織およびサイト固有の薬物動態学 - 薬力学的評価に基づく前立腺炎のための投与レジメンの評価にドリペネムとメロペネムの浸透性を報告した。我々は、血漿および尿中濃度データの薬物動態 - 薬力学の目標達成解析による腎機能障害を有する患者において、イミペネムの最適な投与法を報告した。私たちは、人間の肺とターゲット器官特異的薬力学シミュレーションにおけるセフェピム濃度データの薬物動態学的モデル解析を報告した。私たちは、気管支の上皮被覆液の臨床薬物動態およびクラリスロマイシンとテリスロマイシンの薬力学を報告した。

研究成果

• [雑誌論文] Clinical pharmacokinetics of meropenem in pancreatic juice and site-specific pharmacodynamic target attainment against Gram-negative bacteria : dosing considerations (2014)
  • 著者名/発表者名: Kondo N, Ikawa K, Murakami Y, Uemura K, Sudo T, Hashimoto Y, Ohge H, Morikawa N, Sueda T
  • 雑誌名: Pancreatology 巻: 14
  • 査読あり
• [雑誌論文] Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics (2013)
  • 著者名/発表者名: Karino F, Deguchi N, Kanda H, Ohe M, Kondo K, Tada M, Kuraki T, Nishimura N, Moriyama H, Ikawa K, Morikawa N, Isobe T
  • 雑誌名: J. Infect. Chemother 巻: 19
  • NAID: 10031155825
  • 査読あり
• [雑誌論文] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/ pharmacodynamic evaluation (2013)
  • 著者名/発表者名: Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M
  • 雑誌名: Int. J. Antimicrob. Agents 巻: 41
  • 査読あり
• [雑誌論文] Penetration of meropenem into human pancreatic juice (2013)
  • 著者名/発表者名: Ikawa K, Kondo N, Nakashima A, Yoshizawa K, Morikawa N, Ikeda K, Murakami Y, Ohge H, Sueda T
  • 雑誌名: Scand. J. Infect. Dis 巻: 45
  • 査読あり
• [雑誌論文] Development of initial loading procedure for teicoplanin in critically ill patients with severe infections (2013)
  • 著者名/発表者名: Matsumoto K, Kanazawa N, Watanabe E, Yokoyama Y, Fukamizu T, Shimodozono Y, Maeda C, Yasuda T, Kakihana Y, Ikawa K, Morikawa N, Takeda Y
  • 雑誌名: Biol. Pharm. Bull 巻: 36
  • NAID: 130003361437
  • 査読あり
• [雑誌論文] Population pharmacokinetic-pharmacodynamic target attainment analysis of imipenem plasma and urine data in neonates and children (2013)
  • 著者名/発表者名: Yoshizawa K, Ikawa K, Ikeda K, Ohge H, Morikawa N
  • 雑誌名: Pediatr. Infect. Dis. J 巻: 32
  • 査読あり
• [雑誌論文] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/pharmacodynamic evaluation. (2013)
  • 著者名/発表者名: Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M.
  • 雑誌名: Int. J. Antimicrob. Agents 巻: 41 ページ: 267-271
  • 査読あり
• [雑誌論文] Penetration of meropenem into human pancreatic juice. (2013)
  • 著者名/発表者名: Ikawa K, Kondo N, Nakashima A, Yoshizawa K, Morikawa N, Ikeda K, Murakami Y, Ohge H, Sueda T.
  • 雑誌名: Scand. J. Infect. Dis. 巻: 45 ページ: 404-406
  • 査読あり
• [雑誌論文] Population pharmacokinetic-pharmacodynamic target attainment analysis of imipenem plasma and urine data in neonates and children. (2013)
  • 著者名/発表者名: Yoshizawa K, Ikawa K, Ikeda K, Ohge H, Morikawa N.
  • 雑誌名: Pediatr. Infect. Dis. J. 巻: 32 ページ: 1208-1216
  • 査読あり
• [雑誌論文] Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation (2012)
  • 著者名/発表者名: Nakamura K, Ikawa K, Yamada Y, Arakawa M, Zennami K, Nishikawa G, Ikeda K, Morikawa N, Honda N
  • 雑誌名: J. Chemother 巻: 24
  • 査読あり
• [雑誌論文] Reduction in the incidence of MRSA with use of alcohol-based hand rub solutions and gloves (2012)
  • 著者名/発表者名: Matsumoto K, Shigemi A, Yaji K, Shimodozono Y, Takeda Y, Ikawa K, Morikawa N, Miyanohara H, Kawamura H, Orita M, Tokuda K, Nishi J, Yamada K
  • 雑誌名: J. Infect. Chemother 巻: 18
  • NAID: 10030545826
  • 査読あり
• [雑誌論文] Optimisation of imipenem regimens in patients with impaired renal function by pharmacokinetic-pharmacodynamic target attainment analysis of plasma and urinary concentration data (2012)
  • 著者名/発表者名: Yoshizawa K, Ikawa K, Ikeda K, Kumon H, Ohge H, Morikawa N
  • 雑誌名: Int. J. Antimicrob. Agents 巻: 40
  • 査読あり
• [雑誌論文] Pharmacokinetics of ampicillin-sulbactam and the renal function-based optimization of dosing regimens for prophylaxis in patients undergoing cardiovascular surgery (2012)
  • 著者名/発表者名: Yokoyama Y, Matsumoto K, Yamamoto H, Iguro Y, Imoto Y, Ikawa K, Morikawa N, Ishida S, Okano Y, Watanabe E, Shimodozono Y, Yamada K, Takeda Y
  • 雑誌名: J. Infect. Chemother 巻: 18
  • NAID: 10031143890
  • 査読あり
• [雑誌論文] Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation. (2012)
  • 著者名/発表者名: Nakamura K, Ikawa K, Yamada Y, Arakawa M, Zennami K, Nishikawa G, Ikeda K, Morikawa N, Honda N.
  • 雑誌名: Journal of Chemotherapy 巻: 24 ページ: 32-37
  • 査読あり
• [雑誌論文] Optimisation of imipenem regimens in patients with impaired renal function by pharmacokinetic-pharmacodynamic target attainment analysis of plasma and urinary concentration data. (2012)
  • 著者名/発表者名: Yoshizawa K, Ikawa K, Ikeda K, Kumon H, Ohge H, Morikawa N.
  • 雑誌名: Int J Antimicrob Agents. 巻: 40 ページ: 427-433
  • 査読あり
• [雑誌論文] Reduction in the incidence of MRSA with use of alcohol-based hand rub solutions and gloves. (2012)
  • 著者名/発表者名: Matsumoto K, Shigemi A, Yaji K, Shimodozono Y, Takeda Y, Ikawa K, Morikawa N, Miyanohara H, Kawamura H, Orita M, Tokuda K, Nishi J, Yamada K.
  • 雑誌名: J Infect Chemother. 巻: 18 ページ: 269-271
  • NAID: 10030545826
  • 査読あり
• [雑誌論文] Prostatic Penetration of Meropenem after intravenous Administration in patients Undergoing Transurethral Resection of the Prostate (2011)
  • 著者名/発表者名: Y.Yamada,K.Ikawa, K.Nakamura,K.Mitsui, M.Nakamura, H.Hibi, K.Ikeda, N.Morikawa, N.Honda
  • 雑誌名: Journal of Chemotherapy 巻: 23 ページ: 179-180
  • 査読あり
• [雑誌論文] Safety analysis of liposomal amphotericin B in adult patients: anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia. (2011)
  • 著者名/発表者名: Shigemi A, Matsumoto K, Ikawa K, Yaji K, Shimodozono Y, Morikawa N, Takeda Y, Yamada K
  • 雑誌名: Int J Antimicrob Agents. 巻: 38 ページ: 417-420
  • 査読あり
• [雑誌論文] An initial dosing method for teicoplanin based on the area under the serum concentration time curve required for MRSA eradication. (2011)
  • 著者名/発表者名: Kanazawa N, Matsumoto K, Ikawa K, Fukamizu T, Shigemi A, Yaji K, Shimodozono Y, Morikawa N, Takeda Y, Yamada K.
  • 雑誌名: J Infect Chemother. 巻: 17 ページ: 297-300
  • NAID: 10028171743
  • 査読あり
• [学会発表] Evaluation of predictive pharmacokinetic-pharmacodynamic software coupled with Bayesian method for carbapenem therapy in patients with pneumonia (2013)
  • 著者名/発表者名: Ishihara N, Nishimura N, Karino F, Miura K, Isobe T, Ikawa K, Morikawa N, Naora K
  • 学会等名: 73rd International Pharmaceutical Federation World Congress of Pharmacy and Pharmaceutical Sciences
  • 発表場所: Dublin, Ireland
• [学会発表] Clinical pharmacokinetics of doripenem and meropenem in prostate tissue, and dosing considerations for prostatitis based on site-specific pharmacodynamic target attainment (2013)
  • 著者名/発表者名: Ikawa K, Nakamura K, Nishikawa G, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M
  • 学会等名: 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
  • 発表場所: Salt Lake City, USA
• [学会発表] Pharmacokinetics and pharmacodynamics of biapenem in patients with bacterial pyelonephritis (2013)
  • 著者名/発表者名: Wada K, Yamamoto M, Mitsuhata R, Sako S, Ishii A, Kariyama R, Watanabe T, Ikawa K, Morikawa N, Kumon H
  • 学会等名: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • 発表場所: Yokohama, Japan
• [学会発表] Pharmacodynamics, pharmacokinetics of piperacillin/tazobactam in Japanese elderly patients with nursing and healthcare-associated pneumonia (2013)
  • 著者名/発表者名: Nishimura N, Karino F, Ishihara N, Moriyama H, Miura K, Sutani A, Kuraki T, Ikawa K, Morikawa N, Naora K, Isobe T
  • 学会等名: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • 発表場所: Yokohama, Japan
• [学会発表] Biliary pharmacokinetics and pharmacodynamic target attainment of intravenous pazufloxacin in surgery patients (2013)
  • 著者名/発表者名: Uegami S, Ohge H, Ikawa K, Shigemoto N, Nakashima A, Ikeda K, Morikawa N, Sueda T
  • 学会等名: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • 発表場所: Yokohama, Japan
• [学会発表] Pharmacokinetic and pharmacodynamic evaluation of sulbactam against Acinetobacter baumannii in a murine thigh infection model (2013)
  • 著者名/発表者名: Yokoyama Y, Matsumoto K, Watanabe E, Shigemi A, Umezaki Y, Takeshita A, Nakamura K, Okuno M, Ikawa K, Morikawa N, Takeda Y
  • 学会等名: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • 発表場所: Yokohama, Japan
• [学会発表] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation (2013)
  • 著者名/発表者名: Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Ikeda K, Morikawa N, Sumitomo M
  • 学会等名: 28th Annual Congress of the European Association of Urology
  • 発表場所: Milan, Italy
• [学会発表] Clinical pharmacokinetics of doripenem and meropenem in prostate tissue, and dosing considerations for prostatitis based on site-specific pharmacodynamic target attainment. (2013)
  • 著者名/発表者名: Ikawa K, Nakamura K, Nishikawa G, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M.
  • 学会等名: 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
  • 発表場所: Salt Lake City, USA
• [学会発表] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on site-specific pharmacokinetic- pharmacodynamic evaluation (2012)
  • 著者名/発表者名: Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Morikawa N, Sumitomo M
  • 学会等名: 32nd Congress of the Société Internationale d'Urologie
  • 発表場所: Fukuoka, Japan
• [学会発表] Clinical pharmacokinetics and pharmacodynamics of clarithromycin and telithromycin in epithelial lining fluid of the bronchi (2012)
  • 著者名/発表者名: Ikawa K, Kikuchi E, Kikuchi J, Nishimura M, Derendorf H, Morikawa N
  • 学会等名: 41st Annual Meeting of the American College of Clinical Pharmacology
  • 発表場所: San Diego, USA
• [学会発表] Pharmacokinetic modeling of cefepime concentration data in human lung and target-organ-specific pharmacodynamic simulation (2012)
  • 著者名/発表者名: Ikawa K, Iida S, Morikawa N
  • 学会等名: 1st World Conference on Pharmacometrics
  • 発表場所: Seoul, Korea
• [学会発表] Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic- pharmacodynamic evaluation (2012)
  • 著者名/発表者名: Nakamura K, Ikawa K, Yamada Y, Nishikawa G, Zennami K, Morikawa N, Sumitomo M
  • 学会等名: 27th Annual Congress of the European Association of Urology
  • 発表場所: Paris, France
• [学会発表] Clinical pharmacokinetics and pharmacodynamics of clarithromycin and telithromycin in epithelial lining fluid of the bronchi. (2012)
  • 著者名/発表者名: Ikawa K, Kikuchi E, Kikuchi J, Nishimura M, Derendorf H, Morikawa N.
  • 学会等名: 41st Annual Meeting of the American College of Clinical Pharmacology 2012.
  • 発表場所: San Diego, USA