日本都市部循環器疾患多次元コホートデータベースの開発と有用性に関する検討

• 研究課題/領域番号: 23591073
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 循環器内科学
• 研究機関: 公益財団法人心臓血管研究所
• 研究代表者: 山下 武志 公益財団法人心臓血管研究所, その他部局等, 研究員 (20302721)
• 研究期間 (年度): 2011 – 2013
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2013年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円); 2012年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2011年度: 2,210千円 (直接経費: 1,700千円、間接経費: 510千円)
• キーワード: コホート研究 / 心不全 / 冠動脈疾患 / 不整脈 / データベース

研究概要

本研究では、病院コホート型研究のデータベースを三次元化することを試みた。患者登録時の登録項目（Ｘ軸）に加えて、１年後の新たに加わった患者背景因子や治療（Ｙ軸）を組み込んだうえで、その後の患者アウトカム（Ｚ軸）に結びつけるものである。研究期間中に、（１）データベースに入力する項目の整理、（２）三次元化解析を可能とする新しいデータベースの作成、（３）データベースへの入力を行い、最終的にバグ修正作業を行った上で三次元データベースが完成した。二次元データベースの登録患者は20000例を超え、このデータベースによる循環器領域に関する医療課題を描出し、三次元データベースによる描出との比較が可能となった。

研究成果

• [雑誌論文] Coronary artery diseases in Japanese patients with nonvalvular atrial fibrillation (2014)
  • 著者名/発表者名: Senoo K, Suzuki S, Sagara K, Otsuka T, Matsuno S, Uejima T, Oikawa Y, Yajima J, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Lip GY, Yamashita T
  • 雑誌名: J Cardiol 巻: 63 ページ: 123-7
• [雑誌論文] Rivaroxaban in clinical practice for atrial fibrillation with special reference to prothrombin time (2014)
  • 著者名/発表者名: Suzuki S, Otsuka T, Sagara K, Kano H, Matsuno S, Kato Y, Takai H, Uejima T, Oikawa Y, Nagashima K, Kirigaya H, Yajima J, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Circ J 巻: 78 ページ: 763-6
  • NAID: 130003391010
• [雑誌論文] Progression to the persistent form in asymptomatic paroxysmal atrial fibrillation (2014)
  • 著者名/発表者名: Senoo K, Suzuki S, Otsuka T, Sagara K, Matsuno S, Kano H, Uejima T, Oikawa Y, Yajima J, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Circ J 巻: 78 ページ: 1121-6
  • NAID: 130003391080
• [雑誌論文] Relationship between cardiopulmonary exercise testing parameters and heart failure risk (H2ARDDscore) in atrial fibrillation (2014)
  • 著者名/発表者名: Suzuki S, Koike A, Sagara K, Otsuka T, Kano H, Matsuno S, Kato Y, Takai H, Uejima T, Oikawa Y, Nagashima K, Kirigaya H, Yajima J, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: J Arrhythmia 巻: 30 ページ: 173-9
• [雑誌論文] Effects of statin treatment in patients with coronary artery disease and chronic kidney disease. (2014)
  • 著者名/発表者名: Hidehiro Kaneko, Junji Yajima, Yuji Oikawa, Shingo Tanaka, Daisuke Fukamachi, Shinya Suzuki, Koichi Sagara, Takayuki Otsuka, Shunsuke Matsuno, Ryuichi Funada, Hiroto Kano, Tokuhisa Uejima, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita
  • 雑誌名: Heart Vessels 巻: 29 号: 1 ページ: 21-28
  • DOI: 10.1007/s00380-013-0325-2
  • 査読あり
• [雑誌論文] Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention. (2014)
  • 著者名/発表者名: Hidehiro Kaneko, Junji Yajima, Yuji Oikawa, Shingo Tanaka, Daisuke Fukamachi, Shinya Suzuki, Koichi Sagara, Takayuki Otsuka, Syunsuke Matsuno, Ryuichi Funada Hiroto Kano, Tokuhisa Uejima, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita
  • 雑誌名: Heart Vessels 巻: 29 号: 2 ページ: 156-164
  • DOI: 10.1007/s00380-013-0339-9
  • 査読あり
• [雑誌論文] Coronary artery diseases in Japanese patients with nonvalvular atrial fibrillation (2014)
  • 著者名/発表者名: Keitaro Senoo, Shinya Suzuki, Koichi Sagara, Takayuki Otsuka, Shunsuke Matsuno, Tokuhisa Uejima, Yuji Oikawa, Junji Yajima, Kazuyuki Nagashima, Hajime Kirigaya, Hitoshi Sawada, Tadanori Aizawa, Gregory Y.H. Lip, and Takeshi Yamashita
  • 雑誌名: Journal of Cardiology 巻: 63 号: 2 ページ: 123-127
  • DOI: 10.1016/j.jjcc.2013.08.007
  • 査読あり / オープンアクセス
• [雑誌論文] Role of arterial stiffness and impaired renal function in the progression of new coronary lesions after percutaneous coronary intervention (2013)
  • 著者名/発表者名: Kaneko H, Yajima J, Oikawa Y, Matsuno S, Funada R, Tanaka S, Fukamachi D, Suzuki S, Aizawa T, Yamashita T
  • 雑誌名: Cardiovasc Interv Ther 巻: 28 ページ: 56-62
• [雑誌論文] Effects of statin treatment in patients with coronary artery disease and chronic kidney disease (2013)
  • 著者名/発表者名: Kaneko H, Yajima J, Oikawa Y, Tanaka S, Fukamachi D, Suzuki S, Sagara K, Otsuka T, Matsuno S, Funada R, Kano H, Uejima T, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Heart Vessels
• [雑誌論文] Coronary artery diseases in Japanese patients with nonvalvular atrial fibrillation (2013)
  • 著者名/発表者名: Senoo K, Suzuki S, Sagara K, Otsuka T, Matsuno S, Uejima T, Oikawa Y, Yajima J, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Lip GY, Yamashita T
  • 雑誌名: J Cardiol 巻: 13 ページ: 250-5
• [雑誌論文] Effects of Smoking Habit on the Prevalence of Atrial Fibrillation in Japanese Patients With Special Reference to Sex Differences (2013)
  • 著者名/発表者名: Suzuki S, Sagara K, Otsuka T, Kano H, Matsuno S, Takai H, Uejima T, Oikawa Y, Koike A, Nagashima K, Kirigaya H, Yajima J, Tanabe H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Circ J 巻: (in press)
• [雑誌論文] Blue letter effects: Changes in physicians' attitudes towarddabigatran after a safety advisory in a specialized hospital for cardiovascular care in Japan (2013)
  • 著者名/発表者名: Suzuki S, Sagara K, Otsuka T, Kano H, Matsuno S, Takai H, Uejima T, Oikawa Y, Koike A, Nagashima K, Kirigaya H, Yajima J, Tanabe H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: J Cardiol 巻: 62 ページ: 366-73
• [雑誌論文] Usefulness of frequent supraventricular extrasystoles and a high CHADS2 score to predict first-time appearance of atrial fibrillation (2013)
  • 著者名/発表者名: Suzuki S, Sagara K, Otsuka T, Kano H, Matsuno S, Takai H, Uejima T, Oikawa Y, Koike A, Nagashima K, Kirigaya H, Yajima J, Tanabe H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Am J Cardiol 巻: 111 ページ: 1602-7
• [雑誌論文] Estimated glomerular filtration rate and proteinuria are associated with persistent form of atrial fibrillation : analysis in Japanese patients (2013)
  • 著者名/発表者名: Suzuki S, Sagara K, Otsuka T, Kanou H, Matsuno S, Uejima T, Oikawa Y, Koike A, Nagashima K, Kirigaya H, Yajima J, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: J Cardiol 巻: 61 ページ: 53-7
• [雑誌論文] Obesity paradox in Japanese patients after percutaneous coronary intervention : an observation cohort study (2013)
  • 著者名/発表者名: Kaneko H, Yajima J, Oikawa Y, Tanaka S, Fukamachi D, Suzuki S, Sagara K, Otsuka T, Matsuno S, Funada R, Kano H, Uejima T, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: J Cardiol 巻: 62 ページ: 18-24
• [雑誌論文] Clinical characteristics and long-term clinical outcomes of Japanese heart failure patients with preserved versus reduced left ventricular ejection fraction : a prospective cohort of Shinken Database 2004-2011 (2013)
  • 著者名/発表者名: Kaneko H, Suzuki S, Yajima J, Oikawa Y, Sagara K, Otsuka T, Matsuno S, Kano H, Uejima T, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: J Cardiol 巻: 62 ページ: 102-9
• [雑誌論文] Recent characteristics and outcomes of Japanese stable angina pectoris after percutaneous coronary intervention. An observational cohort study using the Shinken Database (2013)
  • 著者名/発表者名: Kaneko H, Yajima J, Oikawa Y, Tanaka S, Fukamachi D, Suzuki S, Sagara K, Otsuka T, Matsuno S, Funada R, Kano H, Uejima T, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Int Heart J 巻: 54 ページ: 335-40
• [雑誌論文] Clinical characteristics and long-term clinical outcomes of Japanese heart failure patients with preserved versus reduced left ventricular ejection fraction: a prospective cohort of Shinken Database 2004-2011. (2013)
  • 著者名/発表者名: Hidehiro Kaneko, Shinya Suzuki, Junji Yajima, Yuji Oikawa, Koichi Sagara, Takayuki Otsuka, Shunsuke Matsuno, Hiroto Kano, Tokuhisa Uejima, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita
  • 雑誌名: Journal of Cardiology 巻: 62 号: 2 ページ: 102-109
  • DOI: 10.1016/j.jjcc.2013.03.013
  • 査読あり
• [雑誌論文] Obesity Paradox in Japanese Patients after Percutaneous Coronary Intervention: an Observation Cohort Study (2013)
  • 著者名/発表者名: Hidehiro Kaneko, Junji Yajima, Yuji Oikawa, Shingo Tanaka,Daisuke Fukamachi, Shinya Suzuki, Koichi Sagara, Takayuki Otsuka, Shunsuke Matsuno, Ryuichi Funada, Hiroto Kano, Tokuhisa Uejima, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita
  • 雑誌名: Journal of Cardiology 巻: 62 号: 1 ページ: 18-24
  • DOI: 10.1016/j.jjcc.2013.02.009
  • 査読あり
• [雑誌論文] “Blue letter effects”: Changes in physicians’ attitudes toward dabigatran after a safety advisory in a specialized hospital for cardiovascular care in Japan. (2013)
  • 著者名/発表者名: Shinya Suzuki, Koichi Sagara, Takayuki Otsuka, Hiroto Kano, Shunsuke Matsuno, Hideaki Takai, Tokuhisa Uejima, Yuji Oikawa, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Junji Yajima, Hiroaki Tanabe, Hitoshi Sawada, Tadanori Aizawa, and Takeshi Yamashita
  • 雑誌名: Journal of Cardiology 巻: 62 号: 6 ページ: 366-373
  • DOI: 10.1016/j.jjcc.2013.05.016
  • 査読あり
• [雑誌論文] Effects of Smoking Habit on the Prevalence of Atrial Fibrillation in Japanese Patients With Special Reference to Sex Differences– Evidence From the Shinken Database – (2013)
  • 著者名/発表者名: Shinya Suzuki, Koichi Sagara, Takayuki Otsuka, Hiroto Kano, Shunsuke Matsuno, Hideaki Takai, Tokuhisa Uejima, Yuji Oikawa, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Junji Yajima, Hiroaki Tanabe, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita
  • 雑誌名: Circulation Journal 巻: 77 ページ: 2948-2953
  • NAID: 10031203580
  • 査読あり
• [雑誌論文] Usefulness of Frequent Supraventricular Extrasystoles and a High CHADS2 Score to Predict First-Time Appearance of Atrial Fibrillation. (2013)
  • 著者名/発表者名: Shinya Suzuki, Koichi Sagara, Takayuki Otsuka, Hiroto Kano, Shunsuke Matsuno, Hideaki Takai, Tokuhisa Uejima, Yuji Oikawa, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Junji Yajima, Hiroaki Tanabe, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita
  • 雑誌名: American Journal of Cardiology 巻: 111 号: 11 ページ: 1602-1607
  • DOI: 10.1016/j.amjcard.2013.01.335
  • 査読あり
• [雑誌論文] Gender-specific relationships between serum uric acid level and prevalence of atrial fibrillation (2012)
  • 著者名/発表者名: Suzuki S, Otsuka T, Sagara K, Uejima T, Oikawa Y, Yajima J, Koike A, Nagashima K, Kirigaya H, Ogasawara K, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Circ J 巻: 76 ページ: 755-757
• [雑誌論文] Dabigatran in Clinical Practice for Atrial Fibrillation With Special Reference to Activated Partial Thromboplastin Time (2012)
  • 著者名/発表者名: Suzuki S, Otsuka T, Sagara K, Matsuno S, Funada R, Uejima T, Oikawa Y, Yajima J, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Circ J 巻: 76 ページ: 755-757
  • NAID: 10030130511
• [雑誌論文] Relationship between 24-h Holter recordings and clinical outcomes in patients with permanent atrial fibrillation (2012)
  • 著者名/発表者名: Hirano K, Yamashita T, Suzuki S, Hayama E, Matsuoka J, Otsuka T, Sagara K, Fu LT, Sawada H, Aizawa T, Nakazato Y, Daida H
  • 雑誌名: J Cardiol 巻: 60 ページ: 42-6
  • NAID: 10031187767
• [雑誌論文] Distribution of first-detected atrial fibrillation patients without structural heart diseases in symptom classifications (2012)
  • 著者名/発表者名: Senoo K, Suzuki S, Sagara K, Otsuka T, Matsuno S, Funada R, Uejima T, Oikawa Y, Yajima J, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Circ J 巻: 76(4) ページ: 1020-3
  • NAID: 10030131782
• [雑誌論文] Role of cardiopulmonary dysfunction and left atrial remodeling in development of acute decompensated heart failure in chronic heart failure with preserved left ventricular ejection fraction (2012)
  • 著者名/発表者名: Kaneko H, Koike A, Senoo K, Tanaka S, Suzuki S, Nagayama O, Sagara K, Otsuka T, Matsuno S, Funada R, Uejima T, Oikawa Y, Yajima J, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: J Cardiol
  • NAID: 10031187757
• [雑誌論文] A New Scoring System for Evaluating the Risk of Heart Failure Events in Japanese Patients With Atrial Fibrillation (2012)
  • 著者名/発表者名: Suzuki S, Sagara K, Otsuka T, Matsuno S, Funada R, Uejima T, Oikawa Y, Yajima J, Koike A, Nagashima K, Kirigaya H, Sawada H, Aizawa T, Yamashita T
  • 雑誌名: Am J Cardiol
• [雑誌論文] Basic echocardiographic features of patients with latent left ventricular outflow tract obstruction without left ventricular hypertrophy (2012)
  • 著者名/発表者名: Semba H, Sawada H, Uejima T, Takeda N, Soma K, Abe H, Yamashita T, Nagai R
  • 雑誌名: Int Heart J 巻: 53 ページ: 230-3
  • NAID: 130001914152
• [雑誌論文] the Shinken Database Study Group. Impact of early statin initiation on secondary prevention in Japanese patients with coronary artery disease (2011)
  • 著者名/発表者名: Nakamura M, Yamashita T, Yajima J, Oikawa Y, Ogasawara K, Sagara K, Koike A, Kirigaya H, Nagashima K, Otsuka T, Uejima T, Funada R, Matsuno S, Suzuki S, Sawada H, Aizawa T
  • 雑誌名: J Cardiol 巻: 57 ページ: 172-180
• [雑誌論文] Recent mortality of Japanese patients with atrial fibrillation in an urban city of Tokyo (2011)
  • 著者名/発表者名: Suzuki S, Yamashita T, Otsuka T, Sagara K, Uejima T, Oikawa Y, Yajima J, Koike A, Nagashima K, Kirigaya H, Ogasawara K, Sawada H, Aizawa T
  • 雑誌名: J Cardiol 巻: 58 ページ: 116-23
  • NAID: 10031159582