細胞内カルシウム放出制御による新しい悪性高熱症・不整脈の治療開発と臨床応用

• 研究課題/領域番号: 23592256
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 麻酔・蘇生学
• 研究機関: 山口大学
• 研究代表者: 小林 茂樹 山口大学, 医学部附属病院, 講師 (90397993)
• 研究分担者: 山本 健 山口大学, 大学院医学系研究科, 准教授 (50363122) ; 矢野 雅文 山口大学, 大学院医学系研究科, 教授 (90294628)
• 研究期間 (年度): 2011 – 2013
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 5,200千円 (直接経費: 4,000千円、間接経費: 1,200千円); 2013年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2012年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円); 2011年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
• キーワード: 悪性高熱症 / 心室頻拍症 / 心不全 / ダントロレン / リアノジン受容体 / カテコラミン誘発性心室頻拍

研究概要

悪性高熱症(MH)、カテコラミン誘発性多形性心室頻拍症(CPVT)や心不全においては、リアノジン受容体(骨格筋型：RyR1,心筋型：RyR2)内のドメイン連関障害が、RyRからのCa2+漏出の原因と考えられている。MHの治療薬であるダントロレンは、RyR1に結合し、RyR1内のドメイン連関障害を是正し、RyR1からのCa2+漏出を抑制する。イヌ心不全モデルやCPVT型knock-inマウスにおいてもダントンは、RyR2に結合し、RyR2からのCa2+漏出を抑制し、心不全やCPVTを抑制する。このように、ダントロレンはRyR2を分子標的とした新しい心不全・不整脈治療薬となることが期待される。

研究成果

• [雑誌論文] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes (2014)
  • 著者名/発表者名: Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
  • 雑誌名: Biochem Biophys Res Commun 巻: (in press)
  • 査読あり
• [雑誌論文] A low-doseβ1 blocker effectively and safely slows heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation (2014)
  • 著者名/発表者名: Kobayashi S, Murakami W, Myoren T, Tateishi H, Okuda S, Doi M, Nao T, Wada Y, Matsuzaki M. Yano M
  • 雑誌名: Cardiology 巻: 127 ページ: 105-113
  • 査読あり
• [雑誌論文] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes (2014)
  • 著者名/発表者名: Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
  • 雑誌名: Biochem Biophys Res Commun 巻: 448(1) 号: 1 ページ: 1-7
  • DOI: 10.1016/j.bbrc.2014.03.152
  • 査読あり / オープンアクセス
• [雑誌論文] A low-dose β 1-blocker effectively and safely slows the heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation (2014)
  • 著者名/発表者名: Kobayashi S, Murakami W, Myoren T, Tateishi H, Okuda S, Doi M, Nao T, Wada Y, Matsuzaki M, Yano M
  • 雑誌名: Cardiology 巻: 127(2) 号: 2 ページ: 105-13
  • DOI: 10.1159/000355312
  • 査読あり
• [雑誌論文] Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy (2013)
  • 著者名/発表者名: Fujita T, Fujino N, Anan R, Tei C, Kubo T, Doi Y, Kinugawa S, Tsutsui H, Kobayashi S, Yano M, Asakura M, Kitakaze M, Komuro I, Konno T, Hayash Hi, Kawashiri M, Ino H, Yamagishi M
  • 雑誌名: JACC Heart Failure 巻: 6 ページ: 459-466
  • 査読あり
• [雑誌論文] Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy : Results From Multicenter Registration in Japan. (2013)
  • 著者名/発表者名: Fujita T, Komuro I (18人中13番目）
  • 雑誌名: JACC Heart Fail 巻: 6 号: 6 ページ: 459-466
  • DOI: 10.1016/j.jchf.2013.08.007
  • 査読あり
• [雑誌論文] A low-doseβblocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternansin patients with acute decompensated heart failure (2012)
  • 著者名/発表者名: Kobayashi S, Susa T, Tanaka T, Murakami W, Fukuta S, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
  • 雑誌名: Circ J 巻: 76 ページ: 1646-53
  • 査読あり
• [雑誌論文] Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker for predicting cardiac events and evaluating the effectiveness of carvedilol treatment in patients with chronic systolic heart failure (2012)
  • 著者名/発表者名: Susa T, Kobayashi S, Tanaka T, Murakami W, Akashi S, Kunitsugu I, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
  • 雑誌名: Circ J 巻: 76 ページ: 117-26
  • NAID: 10030034360
  • 査読あり
• [雑誌論文] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts (2012)
  • 著者名/発表者名: Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
  • 雑誌名: Cardiovasc Res 巻: 96 ページ: 433-43
  • 査読あり
• [雑誌論文] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts (2012)
  • 著者名/発表者名: Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
  • 雑誌名: Cardiovasc Res 巻: 96(3) 号: 3 ページ: 433-43
  • DOI: 10.1093/cvr/cvs271
  • 査読あり
• [雑誌論文] Low-Dose β-Blocker in Combination With Milrinone Safely Improves Cardiac Function and Eliminates Pulsus Alternans in Patients With Acute Decompensated Heart Failure (2012)
  • 著者名/発表者名: Shigeki Kobayashi et al
  • 雑誌名: Circulation Journal 巻: 76 号: 7 ページ: 1646-1653
  • DOI: 10.1253/circj.CJ-12-0033
  • NAID: 10030503344
  • ISSN: 1346-9843, 1347-4820
  • 査読あり
• [雑誌論文] Urinary 8-Hydroxy-2'-Deoxyguanosine as a Novel Biomarker for Predicting Cardiac Events and Evaluating the Effectiveness of Carvedilol Treatment in Patients With Chronic Systolic Heart Failure (2012)
  • 著者名/発表者名: Susa T, et al
  • 雑誌名: Circulation Journal 巻: 76 号: 1 ページ: 117-126
  • DOI: 10.1253/circj.CJ-11-0537
  • NAID: 10030034360
  • ISSN: 1346-9843, 1347-4820
  • 査読あり
• [雑誌論文] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia (2011)
  • 著者名/発表者名: Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
  • 雑誌名: Circulation 巻: 124 ページ: 682-94
  • 査読あり
• [雑誌論文] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure (2011)
  • 著者名/発表者名: Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M
  • 雑誌名: Eur J Heart Fail 巻: 13 ページ: 29-36
  • 査読あり
• [雑誌論文] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca^<2+> release leading to catecholaminergic polymorphic ventricular tachycardia (2011)
  • 著者名/発表者名: Takeshi Suetomi
  • 雑誌名: Circulation 巻: 124 号: 6 ページ: 682-694
  • DOI: 10.1161/circulationaha.111.023259
  • 査読あり
• [雑誌論文] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure (2011)
  • 著者名/発表者名: Shigeki Kobayashi
  • 雑誌名: European Journal of Heart Faililure 巻: 13 号: 1 ページ: 29-36
  • DOI: 10.1093/eurjhf/hfq178
  • 査読あり
• [学会発表] Relationship between Cardiac 18F-FDG-PET/CT Imaging and Urinary 8-hydroxy-2'-deoxyguanosine as a Biomarker of Oxidative Stress in Patients with Cardiac Sarcoidosis (2014)
  • 著者名/発表者名: Shigeki Kobayashi, Wakako Murakami, Takeki Myoren, Masakazu Fukuda, Kosuke Uchida, Makoto Ono, Hiroki Tateishi, Tetsuro Oda, Ryosuke Kametani, Tomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Masafumi Yano
  • 学会等名: 第７8回日本循環器学会学術集会
  • 発表場所: 東京、国際フォーラム
• [学会発表] A Novel Selective EP4 Receptor Agonist Improves Cardiomyocyte Function by Inhibiting Ca2+ Leak through the Ryanodine Receptor in Failing Cardiomyocytes (2014)
  • 著者名/発表者名: Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
  • 学会等名: 第７8回日本循環器学会学術集会
  • 発表場所: 東京、国際フォーラム
• [学会発表] Mapping the Binding Site of RyR2 “Unzipping” Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes (2014)
  • 著者名/発表者名: Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • 学会等名: 第７8回日本循環器学会学術集会
  • 発表場所: 東京、国際フォーラム
• [学会発表] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation (2014)
  • 著者名/発表者名: Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
  • 学会等名: 第７8回日本循環器学会学術集会
  • 発表場所: 東京、国際フォーラム
• [学会発表] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding (2014)
  • 著者名/発表者名: Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • 学会等名: 第７8回日本循環器学会学術集会
  • 発表場所: 東京、国際フォーラム
• [学会発表] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure (2014)
  • 著者名/発表者名: Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • 学会等名: 第７8回日本循環器学会学術集会
  • 発表場所: 東京、国際フォーラム
• [学会発表] Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy (2014)
  • 著者名/発表者名: Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
  • 学会等名: 第７8回日本循環器学会学術集会
  • 発表場所: 東京、国際フォーラム
• [学会発表] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca^<2+> Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes (2013)
  • 著者名/発表者名: Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
  • 学会等名: 86th Scientific Session of American Heart Association
  • 発表場所: Dallas, (U.S.A)
• [学会発表] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy (2013)
  • 著者名/発表者名: Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
  • 学会等名: 86th Scientific Session of American Heart Association
  • 発表場所: Dallas, USA
• [学会発表] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes (2013)
  • 著者名/発表者名: Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
  • 学会等名: 86th Scientific Session of American Heart Association
  • 発表場所: Dallas, USA
• [学会発表] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation (2013)
  • 著者名/発表者名: Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • 学会等名: 86th Scientific Session of American Heart Association
  • 発表場所: Dallas, USA
• [学会発表] Dantrolene inhibits aberrant Ca2+ release by stabilizing inter-domain interactions within the ryanodine receptor in cardiac troponin T-related familial hypertrophic cardiomyopathy (2013)
  • 著者名/発表者名: Shinichi Okuda, Masakazu Fukuda, Akihiro Hino, Takayoshi Katoh, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki, Masafumi Yano
  • 学会等名: European Society of Cardiololgy Congress 2013
  • 発表場所: Amsterdam, Nederland
• [学会発表] Elevated Myocardial Oxidative Stress Induced by Catecholamines Related to Transient Left Ventricular Cysfunction in Patients With Takotsubo Cardiomyopathy (2012)
  • 著者名/発表者名: Wakako Murakami, Shigeki Kobayashi, Tadamitsu Nakashima, Hiroki Tateishi, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: 85th Scientific Session of American Heart Association
  • 発表場所: Los Angeles, (U.S.A) (Oral)
• [学会発表] Urinary 8-hydroxy-2'-deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosis (2012)
  • 著者名/発表者名: Shigeki Kobayashi, Wakako Murakami, Seiko Fukuta, Masakazu Fukuda, Shinichi Okuda, Tomoko Nao, Masahiro Doi, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: 85th Scientific Session of American Heart Association
  • 発表場所: Los Angeles, (U.S.A) (Oral)
• [学会発表] Fixing Ca^<2+> Leakage From Cardiac Ryanodine Receptor by Low-dose ofβBlocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure (2012)
  • 著者名/発表者名: Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: 5th Scientific Session of American Heart Association
  • 発表場所: Los Angeles, (U.S.A) (Oral)
• [学会発表] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Marker of Left Ventricular Remodelling in Patients With Dilated Cardiomyopathy (2012)
  • 著者名/発表者名: Wakako Murakami, Shigeki Kobayashi, Takamasa Oda, Hiroki Tateishi, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: 85th Scientific Session of American Heart Association
  • 発表場所: Los Angeles, (U.S.A) (Poster)
• [学会発表] Urinary 8-hydroxy-2'-deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosis (2012)
  • 著者名/発表者名: Shigeki Kobayashi, Wakako Murakami, Seiko Fukuta, Masakazu Fukuda, Shinichi Okuda, Tomoko Nao, Masahiro Doi, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: 85th Scientific Session of American Heart Association
  • 発表場所: Los Angeles (USA)
• [学会発表] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose of β Blocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure (2012)
  • 著者名/発表者名: Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: 85th Scientific Session of American Heart Association
  • 発表場所: Los Angeles (USA)
• [学会発表] Elevated Myocardial Oxidative Stress Induced by Catecholamines Related to Transient Left Ventricular Cysfunction in Patients With Takotsubo Cardiomyopathy (2012)
  • 著者名/発表者名: Murakami W, Kobayashi S, Nakashima T,Tateishi H, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T,Yano M, Matsuzaki M
  • 学会等名: 85th Scientific Session of American Heart Association
  • 発表場所: Los Angeles (USA)
• [学会発表] Enhanced Binding of Calmodulin to RyR2 Inhibits Aberrant Ca2+ Release and Arrhythmogenesis in CPVT-Associated Mutation (2012)
  • 著者名/発表者名: Fukuda M, Yamamoto T, Kato T, Hino A, Suetomi T, Tateishi H, Doi M, Okuda S, Kobayashi S, Matsuzaki M, Yano M
  • 学会等名: 85th Scientific Session of American Heart Association
  • 発表場所: Los Angeles(USA)
• [学会発表] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia (2011)
  • 著者名/発表者名: Shigeki Kobayashi, Masafumi Yano,Takeshi Yamamoto, Masunori Matsuzaki
  • 学会等名: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • 発表場所: The National Center of Science Building(Tokyo) (Symposium)
• [学会発表] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis : Insight From Immunohistochemical Technique and ^<18>F-FDG PET/CT (2011)
  • 著者名/発表者名: Seiko Fukuta, Shigeki Kobayashi, Takeo Tanaka, Takehisa Susa, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Shuji Kawamura,Masafumi Yano, Masunori Matsuzaki
  • 学会等名: 84rd Scientific Session of American Heart Association
  • 発表場所: Orlando (U.S.A) (Poster) (Circulation.2011 ;124:A10269)
• [学会発表] Low-dose ofβblocker in combination with milrinone improve cardiac function in patients with acute decompensated heart failure (2011)
  • 著者名/発表者名: Shigeki Kobayashi, Takehisa Susa,Tanaka Takeo, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Tomoko Nao, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: European Society of Cardiololgy Congress 2011
  • 発表場所: Paris(France)(Eur Heart J32[Suppl 1] :785)
• [学会発表] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia (2011)
  • 著者名/発表者名: Shigeki Kobayashi, Masafumi Yano, Takeshi Yamamoto, Masunori Matsuzaki
  • 学会等名: The 28th Annual Meeting of the International Society for Heart Research Japanese Section(招待講演)
  • 発表場所: The National Center of Science Building, Tokyo
• [学会発表] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis: Insight From Immunohistochemical Technique and 18F-FDG PET/CT (2011)
  • 著者名/発表者名: Fukuta S, Kobayashi S, Tanaka T, Susa T, Murakami W, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Ueyama T, Okamura T, Kawamura S, Yano M, Matsuzaki M
  • 学会等名: 84rd Scientific Session of American Heart Association
  • 発表場所: Orland, FL, USA
• [学会発表] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) (2011)
  • 著者名/発表者名: Takeshi Suetomi; Masafumi Yano; Takayoshi Kato; Masakazu Fukuda; Akihiro Hino; Masahiro Doi; Shinichi Okuda; Shigeki Kobayashi; Yasuhiro Ikeda; Takeshi Yamamoto; Masunori Matsuzaki
  • 学会等名: 84rd Scientific Session of American Heart Association
  • 発表場所: Orland, FL, USA
• [学会発表] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation (2011)
  • 著者名/発表者名: Masakazu Fukuda, Masafumi Yano, Takayoshi Kato, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
  • 学会等名: 84rd Scientific Session of American Heart Association
  • 発表場所: Orland, FL, USA
• [学会発表] Low-dose of β blocker in combination with milrinone improve cardiac function in patients with acute decompensated heart failure (2011)
  • 著者名/発表者名: Shigeki Kobayashi, Takehisa Susa,Tanaka Takeo, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Tomoko Nao, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • 学会等名: European Society of Cardiololgy Congress 2011
  • 発表場所: Paris, France
• [図書] β遮断薬を使いこなす -生命予後の改善を目指して- (2013)
  • 著者名/発表者名: 小林 茂樹、矢野雅文
  • 総ページ数: 107
  • 出版者: 月刊循環器
• [図書] β遮断薬を臨床で活かす。 (2013)
  • 著者名/発表者名: 小林 茂樹、矢野雅文
  • 総ページ数: 172
  • 出版者: 南江堂
• [備考]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~ninai/result/paper_eng.html
• [備考] 山口大学大学院医学系研究科 器官病態内科学 ホームページ
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~ninai/medi/stuff.html