習慣流産をおこすG4四重鎖DNA多型

• 研究課題/領域番号: 23659182
• 研究種目: 挑戦的萌芽研究
• 配分区分: 基金
• 研究分野: 人類遺伝学
• 研究機関: 藤田保健衛生大学
• 研究代表者: 倉橋 浩樹 藤田保健衛生大学, 総合医科学研究所, 教授 (30243215)
• 研究期間 (年度): 2011 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円); 2012年度: 1,820千円 (直接経費: 1,400千円、間接経費: 420千円); 2011年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
• キーワード: 習慣流産 / アネキシン A5 / グアニン 4 重鎖 / プロモーター / 多型 / 円旋光二色性 / アネキシンA5 / グアニン4重鎖 / 遺伝子多型 / 二次構造 / SNP

研究概要

私たちは以前の研究で、胎盤性抗凝固因子であるアネキシンA5遺伝子のプロモーター領域にある遺伝子多型が習慣流産と関連し、女性が少数アリルを持つと流産のリスクが増加することを示した。このプロモーター領域の多型の位置にはグアニン4重鎖形成のコンセンサス配列がある。本研究では、プロモーター領域の多型がこのコンセンサスを変化させ、グアニン4重鎖の形成しやすさに影響し、その結果、少数アリルからのアネキシンA5の発現量が低下することが胎盤における過凝固をひきおこし、流産のリスクが増加するという仮説を証明した。

研究成果

• [雑誌論文] Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations (2013)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H
  • 雑誌名: Nat Commun 巻: 4 号: 1 ページ: 1592-1592
  • DOI: 10.1038/ncomms2595
  • 査読あり
• [雑誌論文] MTA3 regulates CGB5 and Snail genes in trophoblast (2013)
  • 著者名/発表者名: Chen Y, Miyazaki J, Nishizawa H, Kurahashi H, Leach R, Wang K
  • 雑誌名: Biochem Biophys Res Commun 巻: (In press) 号: 4 ページ: 379-384
  • DOI: 10.1016/j.bbrc.2013.02.102
  • 査読あり
• [雑誌論文] Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient patient (2013)
  • 著者名/発表者名: Tsuge I, Ito K, Ohye T, Kando N, Kondo Y, Nakajima Y, Inuo C, Kurahashi H, Urisu A
  • 雑誌名: Pediatric Pulmonology 巻: In press
  • 査読あり
• [雑誌論文] Chromosomal translocations and palindromic AT-rich repeats (2012)
  • 著者名/発表者名: Kato T, Kurahashi H, Emanuel BS
  • 雑誌名: Curr Opin Genet Dev 巻: 22 ページ: 221-228
  • 査読あり
• [雑誌論文] HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes (2012)
  • 著者名/発表者名: Kogo, H., Tsutsumi, M., Ohye, T., Inagaki, H., Abe, T., Kurahashi, H.
  • 雑誌名: Genes Cells 巻: 17 号: 6 ページ: 439-454
  • DOI: 10.1111/j.1365-2443.2012.01600.x
  • 査読あり
• [雑誌論文] HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity (2012)
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, Inagaki H, Kiyonari H, Kurahashi H
  • 雑誌名: Genes Cells 巻: 17 号: 11 ページ: 897-912
  • DOI: 10.1111/gtc.12005
  • 査読あり
• [雑誌論文] Failure of homologous synapsis and sex-specific reproduction problems (2012)
  • 著者名/発表者名: Kurahashi H, Kogo H, Tsutsumi M, Inagaki H, Ohye T
  • 雑誌名: Front Genet 巻: 3 ページ: 112-112
  • DOI: 10.3389/fgene.2012.00112
  • 査読あり
• [雑誌論文] Molecular basis of maternal age-related increase in oocyte aneuploidy (2012)
  • 著者名/発表者名: Kurahashi H, Tsutsumi M, Nishiyama S, Kogo H, Inagaki H, Ohye T
  • 雑誌名: Congenit Anom (Kyoto) 巻: 52 号: 1 ページ: 8-15
  • DOI: 10.1111/j.1741-4520.2011.00350.x
  • 査読あり
• [雑誌論文] Mechanism of complex gross chromosomal rearrangements : A commentary on Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation (2012)
  • 著者名/発表者名: Kurahashi H, Ohye T, Inagaki H, Kogo H, Tsutsumi M
  • 雑誌名: J Hum Genet 巻: 57 号: 2 ページ: 81-83
  • DOI: 10.1038/jhg.2011.143
  • NAID: 10030711395
  • 査読あり
• [雑誌論文] Screening of genes involved in chromosome segregation during meiosis I: in vitro gene transfer to mouse fetal oocytes. (2012)
  • 著者名/発表者名: Tsutsumi M, Kowa-Sugiyama H, Bolor H, Kogo H, Inagaki H, Ohye T, Yamada K, Taniguchi-Ikeda M, Toda T, Kurahashi H.
  • 雑誌名: J Hum Genet 巻: 57 号: 8 ページ: 515-522
  • DOI: 10.1038/jhg.2012.61
  • NAID: 10031056588
  • 査読あり
• [雑誌論文] Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia (2012)
  • 著者名/発表者名: Inagaki A, Nishizawa H, Ota S, Suzuki M, Inuzuka H, Miyamura H, Sekiya T, Kurahashi H, Udagawa Y
  • 雑誌名: Placenta 巻: 33 号: 11 ページ: 919-926
  • DOI: 10.1016/j.placenta.2012.08.003
  • 査読あり
• [雑誌論文] Serum neutrophil gelatinase-associated lipocalin during the early postoperative period predicts the recovery of graft function after kidney transplantation from donors after cardiac death (2012)
  • 著者名/発表者名: Kusaka M, Iwamatsu F, Kuroyanagi Y, Nakaya M, Ichino M, Marubashi S, Nagano H, Shiroki R, Kurahashi H, Hoshinaga K
  • 雑誌名: J Urol 巻: 187 号: 6 ページ: 2261-2267
  • DOI: 10.1016/j.juro.2012.01.033
  • 査読あり
• [雑誌論文] A Functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan (2012)
  • 著者名/発表者名: Ahmed WA, Tsutsumi M, Nakata S, Mori T, Nishimura Y, Fujisawa T, Kato I, Nakashima M, Kurahashi H, Suzuki K
  • 雑誌名: Laryngoscope 巻: 122 号: 4 ページ: 925-929
  • DOI: 10.1002/lary.23179
  • 査読あり
• [雑誌論文] Global Gene ExpressionProfiling in PPAR-γ Agonist-TreatedKidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease. (2012)
  • 著者名/発表者名: Yoshihara D, Kugita M, Yamaguchi T, Aukema HM, Kurahashi H, Morita M, Hiki Y, Calvet JP, Wallace DP, Toyohara T, Abe T, Nagao S.
  • 雑誌名: PPAR Res 巻: 2012 ページ: 695898-695898
  • DOI: 10.1155/2012/695898
  • 査読あり
• [雑誌論文] Chromosomal translocations and palindromic... (2012)
  • 著者名/発表者名: Kato T, Kurahashi H, Emanuel BS.
  • 雑誌名: Curr Opin Genet Dev. 巻: in press
  • 査読あり
• [雑誌論文] HORMAD1-dependent checkpoint/surveillance... (2012)
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, et al.
  • 雑誌名: Genes Cells 巻: in press
  • 査読あり
• [雑誌論文] A Functional variation in the hypocretin... (2012)
  • 著者名/発表者名: Ahmed WA, Tsutsumi M, Nakata S, et al.
  • 雑誌名: Laryngoscope 巻: in press
  • 査読あり
• [雑誌論文] Serum neutrophil gelatinase-associated... (2012)
  • 著者名/発表者名: Kusaka M, Iwamatsu F, Kuroyanagi Y, et al.
  • 雑誌名: J Urol 巻: in press
  • 査読あり
• [雑誌論文] DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation (2011)
  • 著者名/発表者名: Kato T, Inagaki H, Tong M, Kogo H, Ohye T, Yamada K, Tsutsumi M, Emanuel BS, Kurahashi H
  • 雑誌名: Mol Cytogenet 巻: 4 号: 1 ページ: 18-18
  • DOI: 10.1186/1755-8166-4-18
  • 査読あり
• [雑誌論文] Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy (2011)
  • 著者名/発表者名: Taniguchi-Ikeda M, Kobayashi K, Kanagawa M, Yu CC, Mori K, Oda T, Kuga A, Kurahashi H, Akman HO, DiMauro S, Kaji R, Yokota T, Takeda S, Toda T
  • 雑誌名: Nature 巻: 478 号: 7367 ページ: 127-131
  • DOI: 10.1038/nature10456
  • 査読あり
• [雑誌論文] Characterization of a novel mouse gene encoding an SYCP3-like protein that re-localizes from the XY body to the nucleolus during prophase of male meiosis I (2011)
  • 著者名/発表者名: Tsutsumi M, Kogo H, Kowa-Sugiyama H, Inagaki H, Ohye T, Kurahashi H
  • 雑誌名: Biol Reprod 巻: 85 号: 1 ページ: 165-171
  • DOI: 10.1095/biolreprod.110.087270
  • 査読あり
• [雑誌論文] Polymorphism in annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
  • 雑誌名: Mol Hum Reprod 巻: 17 号: 7 ページ: 447-452
  • DOI: 10.1093/molehr/gar008
  • 査読あり
• [雑誌論文] A rare synaptonemal complex protein 3 gene variant in unexplained female infertility (2011)
  • 著者名/発表者名: Nishiyama S, Kishi T, Kato T, Suzuki M, Bolor H, Udagawa Y, Kurahashi H
  • 雑誌名: Mol Hum Reprod 巻: 17 号: 4 ページ: 266-271
  • DOI: 10.1093/molehr/gaq098
  • 査読あり
• [雑誌論文] Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction (2011)
  • 著者名/発表者名: Nishizawa H, Ota S, Suzuki M, Kato T, Sekiya T, Kurahashi H, Udagawa Y
  • 雑誌名: Reprod Biol Endocrinol 巻: 9 号: 1 ページ: 107-107
  • DOI: 10.1186/1477-7827-9-107
  • 査読あり
• [雑誌論文] Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients (2011)
  • 著者名/発表者名: Nishizawa H, Suzuki M, Pryor-Koishi K, Sekiya T, Tada S, Kurahashi H, Udagawa Y
  • 雑誌名: Syst Biol Reprod Med 巻: 57 号: 4 ページ: 174-178
  • DOI: 10.3109/19396368.2011.587590
  • 査読あり
• [雑誌論文] Global gene expression profiling in early-stage polycystic kidney disease in the Han : SPRD Cy rat identifies a role for RXR signaling (2011)
  • 著者名/発表者名: Kugita M, Nishii K, Morita M, Yoshihara D, Kowa-Sugiyama H, Yamada K, Yamaguchi T, Wallace DP, Calvet JP, Kurahashi H, Nagao S
  • 雑誌名: Am J Physiol Renal Physiol 巻: 300 号: 1 ページ: F177-F188
  • DOI: 10.1152/ajprenal.00470.2010
  • 査読あり
• [雑誌論文] PPAR-{gamma} agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease (2011)
  • 著者名/発表者名: Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y, Aukema HM, Yamaguchi T, Calvet JP, Wallace DP, Nagao S
  • 雑誌名: Am J Physiol Renal Physiol 巻: 300 号: 2 ページ: F465-F474
  • DOI: 10.1152/ajprenal.00460.2010
  • 査読あり
• [雑誌論文] Lack of Association between Orexin Receptor Genes Polymorphisms and Obstructive Sleep Apnea Syndrome in Japanese (2011)
  • 著者名/発表者名: Ahmed WA, Mori T, Nishimura Y, Kitanaka T, Kato T, Bhardwaj KA, Kurahashi H, Suzuki K.
  • 雑誌名: Sleep Biol Rhythms 巻: 9 ページ: 73-77
  • 査読あり
• [雑誌論文] Lack of Association between Orexin Receptor... (2011)
  • 著者名/発表者名: Ahmed WA, Mori T, Nishimura Y, et al.
  • 雑誌名: Sleep Biol Rhythms 巻: 9 ページ: 73-77
  • 査読あり
• [雑誌論文] Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient patient.
  • 著者名/発表者名: Tsuge I, Ito K, Ohye T, Kando N, Kondo Y, Nakajima Y, Inuo C, Kurahashi H, Urisu A.
  • 雑誌名: Pediatric Pulmonology 巻: (in press)
  • 査読あり
• [学会発表] Mechanism of recurrent translocation t(11;22) initiated by cruciform conformation of palindromes (2012)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kurahashi H.
  • 学会等名: FASEB SRC:"Dynamic DNA structures in biology
  • 発表場所: Saxtons River, USA
• [学会発表] Polymorphisms in the ANXA5gene promoter in Japanese women with preeclampsia (2012)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S,Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kurahashi H, Udagawa Y.
  • 学会等名: The XX FIGO World Congress
  • 発表場所: Rome, Italy
• [学会発表] Pathogenic exon-trapping by SVA retrotransposon and rescue in Faukuyama muscular dystrophy (2012)
  • 著者名/発表者名: Taniguchi M, Kobayashi K, Kanagawa M, Yu CC, Oda T, Kuga A, Kurahashi H, Akmen HO,DiMauro S, Yokota T, Takeda S, Toda T
  • 学会等名: ASHG 2012, annual meeting
  • 発表場所: San Francisco
• [学会発表] Obstetric complication-associated ANXA5promoter polymorphisms affect gene expression via DNA secondary structures (2012)
  • 著者名/発表者名: Inagaki H, Ota S, Nishizawa H, Miyamura H, Nakahira K, Suzuki M, Nishiyama S, Udagawa Y, Yanagihara I, Kurahashi H.
  • 学会等名: ASHG 2012, annual meeting
  • 発表場所: San Francisco
• [学会発表] Polymorphisms in the ANXA5gene promoter in Japanese women with pre-eclampsia (2012)
  • 著者名/発表者名: Kurahashi H, Miyamura H, Nishizawa H, Ota S,Suzuki M, Inagaki A, Egusa H, Nishiyama S, Udagawa Y
  • 学会等名: European Society of Human Genetics Conference 2012
  • 発表場所: Nurnberg, Germany
• [学会発表] Mechanism of recurrent translocation t(11;22) initiated by cruciform conformation of palindromes (2012)
  • 著者名/発表者名: Inagaki, H., Ohye, T., Kogo, H., Tsutsum,i Kurahashi H
  • 学会等名: FASEB SRC:“Dynamic DNA structures in biology”
  • 発表場所: Saxtons River, USA
• [学会発表] Pathogenic exon-trapping by SVA retrotransposon and rescue in Faukuyama muscular dystrophy (2012)
  • 著者名/発表者名: Taniguchi M, Kobayashi K, Kanagawa M, Yu CC, Oda T, Kuga A, Kurahashi H, Akmen HO, DiMauro S, Yokota T, Takeda S, Toda T
  • 学会等名: ASHG 2012, annual meeting
  • 発表場所: San Francisco, USA
• [学会発表] Polymorphisms in the ANXA5gene promoter in Japanese women with pre-eclampsia (2011)
  • 著者名/発表者名: Kurahashi H, Miyamura H, Nishizawa H, Ota S,Suzuki M, Inagaki A, Egusa H, Nishiyama S, Udagawa Y.
  • 学会等名: European Society of Human Genetics Conference 2012.
  • 発表場所: Nurnberg,Germany
• [学会発表] GEN1 resolves cruciform-forming palindromic DNA leading to a recurrent translocation in humans. Keystone Symposia: Functional Consequences of Structural Variation in the Genome (2011)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • 学会等名: Steamboat Springs
  • 発表場所: Colorado, USA
• [学会発表] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Kurahashi H, Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Negi R, Markoff A, Yanagihara I, Udagawa, Y.
  • 学会等名: European Society of Human Genetics Conference 2011.
  • 発表場所: Amsterdam, Netherlands
• [学会発表] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H.
  • 学会等名: 59th Annual Clinical Meeting, ACOG
  • 発表場所: Washington DC, USA
• [学会発表] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T,Imayoshi Y, Markoff A, Yanagihara I,Udagawa Y, Kurahashi H.
  • 学会等名: 27th Annual Meeting of ESHRE - Stockholm 2011
  • 発表場所: Stockholm, Sweden
• [学会発表] Mechanism of recurrent translocation t(11;22) initiated by cruciform conformation of palindromic sequences (2011)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, Tsutsumi M, Kato T, Tong M, Emanuel BS, Kurahashi H.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal,Canada
• [学会発表] Identification of a novel palindrome mediated translocation associated with the t(3;8) of hereditary renal cancer (2011)
  • 著者名/発表者名: Kato T, Sheridan MB, Hacker AM, Inagaki H, Glover TW, Plon SE, Drabkin HA, Gemmill RM, Kurahashi H, Emanuel BS
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Identification of a recombination hotspot sequence at the breakpoint region of the 22q11 deletion using a yeast model (2011)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, Tsutsumi M, Emanuel BS, Kurahashi H.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal,Canada
• [学会発表] HORMAD1-deficiency causes azoospermia in males and pregnancy loss in females (2011)
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, Inagaki H,Kurahashi H.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Mutation in the SYCP3 gene identified in a woman with recurrent pregnancy loss affect the synaptonemal complex conformation at meiotic prophase I (2011)
  • 著者名/発表者名: Tsutsumi M, Kogo H, Inagaki H, Ohye T,Kurahashi H.
  • 学会等名: The 12th International Congress of Human Genetics, Montreal
  • 発表場所: Canada
• [学会発表] Polymorphisms in the annexin A5 gene promoter... (2011)
  • 著者名/発表者名: Kurahashi H, Miyamura H, Nishizawa H, et al.
  • 学会等名: European Society of Human Genetics Conference
  • 発表場所: Amsterdam, Netherlands
• [学会発表] Polymorphisms in the annexin A5 gene promoter... (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, et al.
  • 学会等名: 59th Annual Clinical Meeting, ACOG
  • 発表場所: Washington DC, USA
• [学会発表] Polymorphisms in the annexin A5 gene promoter... (2011)
  • 著者名/発表者名: Miyamura H, Nishizawa H, Ota S, et al.
  • 学会等名: 27th Annual Meeting of ESHRE - Stockholm 2011
  • 発表場所: Stockholm, Sweden
• [学会発表] Mechanism of recurrent translocation t(11;22)... (2011)
  • 著者名/発表者名: Inagaki H, Ohye T, Kogo H, et al.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Identification of a recombination hotspot... (2011)
  • 著者名/発表者名: Ohye T, Inagaki H, Kogo H, et al.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] HORMAD1-deficiency causes azoospermia in males... (2011)
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, et al.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Mutation in the SYCP3 gene identified in a... (2011)
  • 著者名/発表者名: Tsutsumi M, Kogo H, Inagaki H, et al.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] Identification of a novel palindrome mediated... (2011)
  • 著者名/発表者名: Kato T, Sheridan MB, Hacker AM, et al.
  • 学会等名: The 12th International Congress of Human Genetics
  • 発表場所: Montreal, Canada
• [学会発表] HORMAD1-dependent synapsis checkpoint in... (2011)
  • 著者名/発表者名: Kogo H, Tsutsumi M, Ohye T, et al.
  • 学会等名: 2011 FASEB Summer Research Conferences
  • 発表場所: Steamboat Springs, USA
• [学会発表] PPAR-gamma agonist ameliorates kidney and liver... (2011)
  • 著者名/発表者名: Yoshihara D, Kurahashi H, Morita M, et al.
  • 学会等名: World Congress of Nephrology 2011
  • 発表場所: Vancouver, Canada
• [学会発表] Global gene expression profiling in kidneys of... (2011)
  • 著者名/発表者名: Yoshihara D, Kugita M, Kurahashi H, et al.
  • 学会等名: American Society of Nephrology 44th Annual Meeting
  • 発表場所: Philadelphia, PA USA
• [備考] 藤田保健衛生大学・総合医科学研究所
  • URL: http://www.fujita-hu.ac.jp/ICMS/
• [備考] 分子遺伝学研究部門
  • URL: http://www.fujita-hu.ac.jp/?genome/mg/
• [備考] 研究代表者が運営
  • URL: http://www.fujita-hu.ac.jp/?genome/11&22/
• [備考] 藤田保健衛生大学・総合医科学研究所
  • URL: http://www.fujita-hu.ac.jp/ICMS/
• [備考] 藤田保健衛生大学・総合医科学研究所・分子遺伝学研究部門
  • URL: http://www.fujita-hu.ac.jp/~genome/mg/