形状記憶合金と MEMS 技術による低侵襲で広範・高密度な皮質脳波計測技術の開発

• 研究課題/領域番号: 23700493
• 研究種目: 若手研究(B)
• 配分区分: 基金
• 研究分野: 融合脳計測科学
• 研究機関: 静岡大学
• 研究代表者: 山川 俊貴 静岡大学, 工学部, 助教 (60510419)
• 研究期間 (年度): 2011 – 2012
• 研究課題ステータス: 完了 (2012年度)
• 配分額: 4,290千円 (直接経費: 3,300千円、間接経費: 990千円); 2012年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円); 2011年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
• キーワード: 脳活動記録(レコーディング) / 硬膜下電極 / 低侵襲 / フレキシブル回路技術 / ポリイミド / 形状記憶合金 / ＭＥＭＳ / 皮質脳波 / てんかん

研究概要

低侵襲な手術で硬膜下に挿入可能で、かつ侵襲部位よりも広範な領域の皮質脳波を、従来の硬膜下電極に比べ高い空間分解能(高密度)で計測可能な電極アレイを開発した。生体への長期留置環境を模擬したファントム実験において、電極の電気特性を評価し、生体への長期留置に耐える耐久性と安全性を備えていることを確認した。また、サルを用いた動物実験において、その留置手法の安全性と試作デバイスの脳波計測機能を実証した。

研究成果

• [雑誌論文] Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective. (2013)
  • 著者名/発表者名: Yeting He
  • 雑誌名: Brain Res 巻: 1497 ページ: 53-60
  • DOI: 10.1016/j.brainres.2012.11.041
  • 査読あり
• [雑誌論文] Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions (2011)
  • 著者名/発表者名: Fujii M, et al
  • 雑誌名: Epilepsia 巻: 53 号: 3 ページ: 489-493
  • DOI: 10.1111/j.1528-1167.2011.03388.x
  • 査読あり
• [雑誌論文] Subdural Electrocorticogram Measurement with a Minimally-Invasive Procedure using an SMA-Manipulated Microelectrode Array (2011)
  • 著者名/発表者名: Toshitaka Yamakawa
  • 雑誌名: Advanced Materials Research 巻: 222 ページ: 313-317
  • DOI: 10.4028/www.scientific.net/amr.222.313
  • 査読あり
• [学会発表] A Minimally Invasive Brain-Machine Interface Employing Flexible Electronics (2012)
  • 著者名/発表者名: Toshitaka Yamakawa, Toru Aoki, Takao Inoue, Masami Fujii, Michiyasu Suzuki, Takeshi Yamakawa
  • 学会等名: The 14th Takayanagi Kenjiro Memorial Symposium - Toward Advanced Imagince Science Creation
  • 発表場所: 浜松市
• [学会発表] Flexible Electronics for Diagnostics and Treatment of Intractable Epilepsy (2012)
  • 著者名/発表者名: Toshitaka Yamakawa, Toru Aoki, Takao Inoue, Masami Fujii, Michiyasu Suzuki, Takeshi Yamakawa
  • 学会等名: 13th International Young Scientists Conference Optics and High Technology Material Science - SPO 2012
  • 発表場所: Kyiv(ウクライナ)
• [学会発表] Measurement Sensitivity of Deep Artery on Transabdominal Fetal Pulse Oximetry (2012)
  • 著者名/発表者名: Tetsuya Iwano, Norbert Stuban, Toshitaka Yamakawa, Masatsugu Niwayama
  • 学会等名: 34th Annual International IEEE EMBS Conference
  • 発表場所: San Diego(米国)
• [学会発表] Theoretical and Experimental Study for Determination of Characteristics of Bone Tissue Using Diffuse Reflectance (2012)
  • 著者名/発表者名: Daisuke Wakabayashi, Kazuki Wakamori, Toshitaka Yamakawa, Masatsugu Niwayama
  • 学会等名: 34th Annual International IEEE EMBS Conference
  • 発表場所: San Diego(米国)
• [学会発表] Design and Electrochemical Characterization of Polyimide Based Subdural Grid Electrodes for Minimally-Invasive Implantation (2012)
  • 著者名/発表者名: Manato Kimura, Toru Aoki, Masatsugu Niwayama, Toshitaka Yamakawa
  • 学会等名: 34th Annual International IEEE EMBS Conference
  • 発表場所: San Diego(米国)
• [学会発表] Development of a Focal Brain Cooling Device for the Treatment of Intractable Epilepsy (2012)
  • 著者名/発表者名: Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Tatsuji Tokiwa, Shuji Aou, Toru Aoki, Yuichi Maruta, Masami Fujii, Michiyasu Suzuki
  • 学会等名: International Conference on Advanced Materials
  • 発表場所: Colombo(スリランカ)
• [学会発表] A Minimally Invasive Brain-Machine Interface Employing Flexible Electronics (2012)
  • 著者名/発表者名: Toshitaka Yamakawa
  • 学会等名: The 14th Takayanagi Kenjiro Memorial Symposium
  • 発表場所: 静岡大学(浜松市)
  • 招待講演
• [学会発表] Flexible Electronics for Diagnostics and Treatment of Intractable Epilepsy (2012)
  • 著者名/発表者名: Toshitaka Yamakawa
  • 学会等名: 13th International Young Scientists Conference Optics and High Technology Material Science
  • 発表場所: キエフ国立大学(ウクライナ)
  • 招待講演
• [学会発表] Measurement Sensitivity of Deep Artery on Transabdominal Fetal Pulse Oximetry (2012)
  • 著者名/発表者名: Tetsuya Iwano
  • 学会等名: 34th Annual International IEEE EMBS Conference
  • 発表場所: Hilton San Diego Bayfront(米国)
• [学会発表] Theoretical and Experimental Study for Determination of Characteristics of Bone Tissue Using Diffuse Reflectance (2012)
  • 著者名/発表者名: Daisuke Wakabayashi
  • 学会等名: 34th Annual International IEEE EMBS Conference
  • 発表場所: Hilton San Diego Bayfront(米国)
• [学会発表] Design and Electrochemical Characterization of Polyimide Based Subdural Grid Electrodes for Minimally-Invasive Implantation (2012)
  • 著者名/発表者名: Manato Kimura
  • 学会等名: 34th Annual International IEEE EMBS Conference
  • 発表場所: Hilton San Diego Bayfront(米国)
• [学会発表] Development of a Focal Brain Cooling Device for the Treatment of Intractable Epilepsy (2012)
  • 著者名/発表者名: Toshitaka Yamakawa
  • 学会等名: International Conference on Advanced Materials, Science and Engineering 2012
  • 発表場所: Galle Face Hotel(スリランカ)
  • 招待講演
• [学会発表] Cool the Brain: A novel strategy to control the abnormal brain activity (2011)
  • 著者名/発表者名: Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Tatsuji Tokiwa, Shuji Aou, Toru Aoki, Yuichi Maruta, Masami Fujii, Michiyasu Suzuki
  • 学会等名: 12th International Young Scientists Conference Optics and High Technology Material Science - SPO 2011
  • 発表場所: Kyiv(ウクライナ)
• [学会発表] Minimally-Invasive Epileptogenic Focus Detection Using the Subdural Electrodes Manipulated by the Shape-Memory-Alloy Thin Wire (2011)
  • 著者名/発表者名: Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Shuji Aou, Tatsuji Tokiwa, Masami Fujii, Michiyasu Suzuki
  • 学会等名: 2011 International Conference on Systems, Man, Cybernetics
  • 発表場所: Anchorage(米国)
• [学会発表] Development of a focal cerebral cooling system for the treatment of intractable epilepsy: An experimental study in cats and non-human primates (2011)
  • 著者名/発表者名: Takao Inoue, Masami Fujii, Yeting He, Yuichi Maruta, Hiroyuki Kida, Sadahiro Nomura, Michiyasu Suzuki, Toshitaka Yamakawa, Tatsuji Tokiwa, Takeshi Yamakawa, Kenichi Hirano, Masanori Niiyama, Hiromi Yamazaki
  • 学会等名: 2011 International Conference on Systems, Man, Cybernetics
  • 発表場所: Anchorage(米国)
• [学会発表] Alterative treatment of intractable epilepsy with focal brain cooling -A review of our past studies (2011)
  • 著者名/発表者名: Masami Fujii, Takao Inoue, Yeting He, Yuichi Maruta, Hirochika Imoto, Hiroyasu Koizumi, Sadahiro Nomura, Tatsuji Tokiwa, Satoshi Ishizuka, Takeshi Yamakawa, Toshitaka Yamakawa
  • 学会等名: 2011 International Conference on Systems, Man, Cybernetics
  • 発表場所: Anchorage(米国)
• [学会発表] Minimally-invasive ECoG recording using the novel subdural electrodes manipulated by a shape memory alloy guidewire (2011)
  • 著者名/発表者名: Toshitaka Yamakawa, Takeshi Yamakawa, Takao Inoue, Shuji Aou, Satoru Ishizuka, Masami Fujii, Michiyasu Suzuki
  • 学会等名: 29th International Epilepsy Congress
  • 発表場所: Rome(イタリア)
• [学会発表] Alterative treatment of intractable epilepsy with focal brain cooling (2011)
  • 著者名/発表者名: Masami Fujii, Takao Inoue, Y. He, H. Imoto, N. Tanaka, T. Oku, Yuichi Maruta, H. Koizumi, S. Nomura, Y. Owada, T. Saito, Toshitaka Yamakawa, T. Tokiwa, Takeshi Yamakawa, Michiyasu Suzuki
  • 学会等名: 29th International Epilepsy Congress
  • 発表場所: Rome(イタリア)
• [学会発表] Energy Discriminated X-ray CT using High Count Rate Photon (2011)
  • 著者名/発表者名: Toru Aoki, Akifumi Koike, Takaharu Okunoyama, Hisashi Morii, Shailendra Singh, Manato Kimura, Toshitaka Yamakawa, Hidenori Mimura
  • 発表場所: San Diego(米国)
• [学会発表] Carrier Transportation Properties in M-p-n and Schottky CdTe Diode (2011)
  • 著者名/発表者名: Manato Kimura, Akifumi Koike, Takaharu Okunoyama, Hisashi Morii, Shailendra Singh, Toshitaka Yamakawa, Hidenori Mimura, Toru Aoki
  • 学会等名: 2011 SPIE Optics + Photonics
  • 発表場所: San Diego(米国)
• [学会発表] A Low-Cost Long-Life R-R Interval Telemeter with Automatic Gain Control for Various ECG Amplitudes (2011)
  • 著者名/発表者名: Toshitaka Yamakawa, Genki Matsumoto, Toru Aoki
  • 学会等名: Inter-Academia 2011
  • 発表場所: Sucevita(ルーマニア)
• [学会発表] Cool the Brain: A novel strategy to control the abnormal brain activity (2011)
  • 著者名/発表者名: Toshitaka Yamakawa
  • 学会等名: 12th International Young Scientists Conference Optics and High Technology Material Science(招待講演)
  • 発表場所: キエフ国立大学(ウクライナ)
• [学会発表] Minimally-Invasive Epileptogenic Focus Detection Using the Subdural Electrodes Manipulated by the Shape-Memory-Alloy Thin Wire (2011)
  • 著者名/発表者名: Toshitaka Yamakawa
  • 学会等名: 2011 International Conference on Systems, Man, Cybernetics
  • 発表場所: ヒルトン・アンカレッジ(米国)
• [学会発表] Minimally-Invasive ECoG Recording Using the Novel Subdural Electrodes Manipulated by a Shape Memory Alloy Guidewire (2011)
  • 著者名/発表者名: Toshitaka Yamakawa
  • 学会等名: 29th International Epilepsy Congress
  • 発表場所: マリオット・ローマパークホテル(イタリア)
• [備考]
  • URL: http://www.ipc.shizuoka.ac.jp/ttyamak/