配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2025年度: 390千円 (直接経費: 300千円、間接経費: 90千円)
2024年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2023年度: 2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
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研究開始時の研究の概要 |
Nicotine and ethanol (EtOH) are often consumed together and produce an additive increase in dopamine release in the nucleus accumbens. COA-Cl has recently been shown to increase dopamine levels and to exert neuroprotective effects both in vivo and in vitro. Thus, the present study is aimed to investigate whether a combination of COA-Cl, EtOH and/or nicotine exerts additive neuroprotective effects against MPTP-induced neurotoxicity, and to identify its underlying mechanisms, with a focus on apoptosis.
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