| 研究課題/領域番号 |
23K13760
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分34010:無機・錯体化学関連
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| 研究機関 | 東京工業大学 |
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研究代表者 |
CATTI LORENZO 東京工業大学, 科学技術創成研究院, 助教 (50873478)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2025年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2024年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2023年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
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| キーワード | functionalized capsule / functionalized ligand / heterocapsule / テルペン環化反応 |
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| 研究開始時の研究の概要 |
Preparation of novel ligands with covalently attached acid functionalities.
Formation of nanosized M2L4 coordination capsules via self-assembly of these ligands in the presence of metal ions (Pd2+ or Pt2+).
Cyclization of linear terpene substrates inside the obtained capsules via protonation in water.
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| 研究実績の概要 |
The synthesis of a new bent endo-functionalized bispyridine ligand was achieved. During the synthesis the convex-selective deprotection of the alkoxy groups was successfully performed. The ligand features an internal OAc or OH substituent. Combination of this ligand with metal ions resulted in the formation of an internally functionalized coordination capsule, as indicated by NMR analysis. The formed capsule is believed to contain both internal OH and OAc functionalities, since a mixture of the functionalized ligand was used. Formation of such heterocapsules is an important step toward mimicking the active centers of natural enzymes.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The synthesis of the ligand was achieved without major problems. Importantly, the obtained OH functionalized ligand can likely be converted into other functionalized ligands, e.g. ones containing acidic groups. Additionally, current NMR data indicates formation of otherwise difficult-to-obtain heterocapsules, which might prove valuable for the selective recognition of biomolecules in water.
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| 今後の研究の推進方策 |
First the purification of the obtained ligand will be finalized, since the current ligand is obtained as a mixture of OH- and OAc-functionalized ligands. With the separated ligands in hand, we will first study the formation of homocapsules and their selective guest-uptake abilities. Next we will study the selective formation of e.g. 2+2 heterocapsules using a mixture of functionalized and unfunctionalized ligands. Selective formation will be attempted using template guest molecules or using functionalized ligands with sterically bulky substituents.
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