| 研究課題/領域番号 |
23K14502
|
|---|
| 研究種目 |
若手研究
|
| 配分区分 | 基金 |
|---|
| 審査区分 |
小区分49030:実験病理学関連
|
|---|
| 研究機関 | 大阪大学 |
|---|
研究代表者 |
ZEYNEP BAL 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (40924064)
|
|---|
| 研究期間 (年度) |
2023-04-01 – 2025-03-31
|
| 研究課題ステータス |
交付 (2023年度)
|
| 配分額 *注記 |
4,420千円 (直接経費: 3,400千円、間接経費: 1,020千円)
2024年度: 2,470千円 (直接経費: 1,900千円、間接経費: 570千円)
2023年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
|
|---|
| キーワード | osteonecrosis / vascularisation / bone regeneration / vascular regeneration / stem cells / Osteonecrosis / Vascularisation |
|---|
| 研究開始時の研究の概要 |
Osteonecrosis of the Femoral Head (ONFH) is an osteonecrotic condition originated from the inadequate blood supply to bone and has a high rate of disability. Until now the molecular aetiology behind ONFH has not been clarified. This study aims to develop a surgical mouse model for ONFH for the first time in the literature to clarify the molecular mechanisms leading to traumatic ONFH; in purpose of developing a regenerative treatment by transplantation of a specialised endothelial cell side population which can be applicable in clinics
|
| 研究実績の概要 |
Osteonecrosis of the Femoral Head (ONFH) is an osteonecrotic condition with a high rate of disability, originated from the inadequate blood supply to femoral head and the molecular aetiology behind traumatic ONFH has not been clarified yet. Thus we aimed to develop a mice trauma model to study the traumatic ONFH in detail and with in one year the model was able to be developed and the changes in vascularisation between necrotic bone and healthy bone are started to be observed already.
|
| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
The method in animal experiment has changed.
|
| 今後の研究の推進方策 |
Until now, we almost developed a mice model for traumatic ONFH and we started to observe the differences in vascular structures in necrotic femoral head and heathy one. From now on the vascularisation process in necrotic bone tissue and healthy bone tissue will be observed as well as the macrophage and neutrophil changes in two different situations. Also a treatment strategy with the help of an EC side population will try to be developed. Meanwhile if there will be a chance we also want to observe the differences between steroid induced ONFH and traumatic ONFH in disease development.
|
