| 研究課題/領域番号 |
23K14541
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分49070:免疫学関連
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| 研究機関 | 大阪大学 |
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研究代表者 |
Guenther Carla 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (00967135)
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| 研究期間 (年度) |
2023-04-01 – 2028-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2027年度: 390千円 (直接経費: 300千円、間接経費: 90千円)
2026年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
2025年度: 650千円 (直接経費: 500千円、間接経費: 150千円)
2024年度: 1,170千円 (直接経費: 900千円、間接経費: 270千円)
2023年度: 780千円 (直接経費: 600千円、間接経費: 180千円)
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| キーワード | Mechanotransduction / Innate Immune regulation / Oncoimmunology / Aging / Cell Signaling / Mechanoimmunology / CLR / Immunology |
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| 研究開始時の研究の概要 |
Identifying central regulatory pathways that control innate immune cell gene expression and resulting phenotypes in response to mechanical stimuli on resting cells and stimulated cells.
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| 研究実績の概要 |
The research project has progressed into three subprojects: 1) Innate immune cell type was found to depend on substrate stiffness (hard or soft) regardless of stimulation. This mechanism also works in the presence of cancer cells but is twisted to support cancer growth (manuscript was submitted). 2) The mechanism with which cells sense stiffness seems to be disturbed in aged immune cells. This might be due to decline of protein quality in age and might result in immune system dysregulation arising with advanced age. The manuscript is in preparation.
3) An important regulatory protein, that merges stiffness signals with bacterial signals inside of immune cells was identified. Other proteins interacting with this regulator will be identified to clarify the mechanism.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
The research project has yielded many results to the extend, that three subprojects have developed. The main project has progressed into a manuscript that is currently submitted and has been deposited into bioRxiv. A smaller manuscript on disturbed mechanosignaling in aged cells is in preparation and planned to be submitted by the end of the year.
A third project on key intracellular signaling regulators has emerged due to interesting findings but these findings are just initial results and much more work over next few years is required to yield another manuscript. Nevertheless these findings are novel and challenge the current view on intracellular signaling.
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| 今後の研究の推進方策 |
The main focus this year is on fully publishing the first manuscript and doing the required revisions. In the meantime work on the second manuscript is done. The age related manuscript has become a bit complicated and so a collaboration with an expert in protein translation is discussed and has already resulted in new ideas for experiments and a strategy for further progress. The same collaborator is also helping with establishing a key assay for the third project.
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