| 研究課題/領域番号 |
23K14927
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分52040:放射線科学関連
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| 研究機関 | 順天堂大学 |
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研究代表者 |
アンディカ クリスティーナ 順天堂大学, 健康データサイエンス学部, 講師 (00965460)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2025年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2024年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2023年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
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| キーワード | Glymphatic system / Metabolic sydrome / Marijuana / DTI-ALPS / Free water imaging / Metabolic syndrome / Cognitive decline / Motor impairment / MRI |
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| 研究開始時の研究の概要 |
Metabolic syndrome (MetS) has recently been linked to reduced removal of brain waste products, leading to cognitive decline and motor impairment. Our study aims to: (A) develop and validate noninvasive MRI-based biomarkers for elucidating the effect of MetS or its components on glymphatic system compartments; (B) predict subjects with MetS or its components at risk of developing glymphatic dysfunction-related cognitive decline and motor impairment; and (C) clarify vascular and modifiable lifestyle risk factors of glymphatic dysfunction for integrating preventive and therapeutic strategies.
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| 研究実績の概要 |
In the present research project, diffusion magnetic resonance imaging-based measures were applied to evaluate the glymphatic system function. The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance.
Our findings were as follows:
1. Glymphatic system alterations in older adults with metabolic sydrome: we showed reduced glymphatic clearance function in older adults with metabolic syndrome, possibly due to the adverse effects of vascular risk factors on the glymphatic system. Our findings also indicate associations between reduced glymphatic clearance function and elevated diastolic blood pressure, hyperglycemia, smoking habit, and poorer cognitive performance.
2. Glymphatic system alterations in marijuana users: we observed the adverse effects of younger age at first use of marijuana on glymphatic system function, which is associated with impaired working memory and fluid intelligence.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
As planned, data can be collected in a timely manner, and data analysis and paper writing can also proceed according to schedule.
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| 今後の研究の推進方策 |
Data analysis is currently underway to evaluate the relationship between impaired glymphatic system function and changes in brain microstructure.
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