| 研究課題/領域番号 |
23K15292
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| 研究種目 |
若手研究
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| 配分区分 | 基金 |
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| 審査区分 |
小区分53050:皮膚科学関連
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| 研究機関 | 順天堂大学 |
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研究代表者 |
趙 巧鳳 順天堂大学, 大学院医学研究科, 博士研究員 (60934601)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2025年度: 910千円 (直接経費: 700千円、間接経費: 210千円)
2024年度: 1,690千円 (直接経費: 1,300千円、間接経費: 390千円)
2023年度: 2,080千円 (直接経費: 1,600千円、間接経費: 480千円)
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| キーワード | Stress / Atopic dermatitis |
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| 研究開始時の研究の概要 |
Atopic dermatitis (AD), which is a chronic inflammatory skin disease, manifests as intractable itch. Psychological stress may have a role in the onset or exacerbation of skin disorders such as AD. However, pathophysiologic links between psychological stressors and cutaneous manifestations remain unclear. Therefore, this study focuses on the hypothalamic-pituitary-adrenal axis (HPA) and aims to elucidate the mechanism of exacerbation of the pathogenesis of atopic dermatitis, including itching and dermatitis, and delayed recovery by applying psychological stress to a mouse model of AD.
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| 研究実績の概要 |
Atopic dermatitis (AD), which is a chronic inflammatory skin disease, manifests as intractable itch. Psychological stress may have a role in the onset or exacerbation of skin disorders such as AD. Psychological stress may influence AD, but the links between psychological stressors and cutaneous manifestations remain unclear.
I have completed the essential techniques for studying Project 1, which include the following steps:
1. Inducing AD-like symptoms; 2. Selecting stressors: Three different types of stressors are selected for stress loading, including WS, RS, and R-SDS; 3. Evaluating the effects of stress on AD symptoms; 4. Studying the effects of stress on alloknesis.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The following research project 1(Generation of AD-like model and evaluation of psychological stress load) was completed last year.
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| 今後の研究の推進方策 |
The following research Project 2:Effects of psychological stress on the structure and function of skin barrier and sensory nerve fibers:
1, [Effects of stress on AD symptoms] The selected stresses will be given from the AD-induced process to NC/Nga mice to evaluate the skin barrier itch behavior and the degree of dermatitis to study the effect of stress on AD pathogenesis.
2, [Effects of stress on sensory nerve fibers] To further confirm the skin barrier disruption and sensory nerve fibers, I will collect and analyze the skin tissues from each group for immunohistochemical and histology.
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