| 研究課題/領域番号 |
23K19220
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| 研究種目 |
研究活動スタート支援
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| 配分区分 | 基金 |
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| 審査区分 |
0403:人間医工学およびその関連分野
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| 研究機関 | 九州大学 |
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研究代表者 |
WEN PANYUE 九州大学, 先導物質化学研究所, 学術研究員 (00976623)
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| 研究期間 (年度) |
2023-08-31 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
2024年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2023年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | poly(2-oxazoline) / medical devices / Biocompatible coatings / Medical devices / Biocompatibility / Polymer / Polyoxazoline |
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| 研究開始時の研究の概要 |
New poly(2-oxazoline)-based pseudo-peptido-coating (PP-coating) is proposed as biocompatible coating for high performance medical devices. The new poly(2-oxazoline) coating is expected to have strong hydration ability. The hydration can be further fine-tuned through changing the carbon number of alkyl group at side chain of poly(2-oxazoline), thus enabling PP-coating to maintain improved biocompatibility even working in the long-term.
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| 研究実績の概要 |
We successfully prepared a new poly(2-oxazoline), poly(2-ethoxycarbonylethyl-2-oxazoline) and applied coating to several common substrate materials of medical devices including PMMA, PP, PS, PC, and PET. The small contact angle clearly indicates that our new poly(2-oxazoline) coating is more hydrophilic than PMEA coating [~25° for poly(2-oxazoline) vs ~45° for PMEA].
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The Institute for Materials Chemistry and Engineering (IMCE) is an international research institute at Kyushu University promoting research related to the basic science and application of the structure and functions of materials from an atomic, molecular, to supramolecular scale. Particularly, the PI is now working in Prof. Masaru Tanaka Lab. Prof. Tanaka is an expert in the field of biocompatible materials and will provide advisory suggestions for this research. The multidisciplinary and international research team is organized in IMCE.These advanced facilities and multidisciplinary and international team would lay a solid foundation to achieve the research goal.
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| 今後の研究の推進方策 |
The applicant already synthesized one poly(2-oxazoline) and confirmed it can be solubilized in ethanol, allowing methanol-free operation. These preliminary results show that the proposed pseudo-peptido-coating is promising to serve as biocompatible coating for medical devices. The applicant will further control the structure of poly(2-oxazoline) and study performance in details including long-term efficacy, to find the best candidate of pseudo-peptido-coating.
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