| 研究課題/領域番号 |
23K19456
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| 研究種目 |
研究活動スタート支援
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| 配分区分 | 基金 |
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| 審査区分 |
0802:生体の構造と機能およびその関連分野
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| 研究機関 | 山口大学 |
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研究代表者 |
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| 研究期間 (年度) |
2023-08-31 – 2025-03-31
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| 研究課題ステータス |
交付 (2023年度)
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| 配分額 *注記 |
2,860千円 (直接経費: 2,200千円、間接経費: 660千円)
2024年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2023年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
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| キーワード | HAP1 / steroid / Brain / rodent / Steroid hormone / Stigmoid body |
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| 研究開始時の研究の概要 |
1. Elucidation of the relationships of STB/HAP1 with Steroid hormone receptors in vivo.
2. Assessments of effects of STB/HAP1 on serum hormone concentration.
3. Examination of effects of STB/HAP1 on the number of SHR-immunoreactive neurons.
4. Clarification of the effects of STB/HAP1 and steroid hormone-related functions.
5. Action in the event that the research does not progress as originally planned.
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| 研究実績の概要 |
Our previous in vitro findings suggest that STB/HAP1 could be related to the subcellular regulation of SHRs. In this research project to clarify the in vivo effects of STB/HAP1 in regulating or protecting the functions of sex steroids via their receptors; AR and ER, I examined the detailed in vivo immunohistochemical relationships of HAP1 with AR, and ER in the preoptic area and hypothalamic areas in adult mice. I found that HAP1 was highly coexpressed with both the sex steroid receptors in the different brain regions, which is suggestive of HAP1 modification of the steroidal functions in the brain.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
I have completed my first objective, clarifying the in vivo relationships of STB/HAP1 with different steroid receptors. I have presented my research findings at several academic conferences.
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| 今後の研究の推進方策 |
1. Assessments of effects of STB/HAP1 on serum hormone concentration.
2. Examination of effects of STB/HAP1 on the number of SHR-immunoreactive neurons.
3. Clarification of the effects of STB/HAP1 and steroid hormone-related functions.
4. Action if the research has yet to progress as planned initially.
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