| 研究課題/領域番号 |
23K20915
|
|---|
| 補助金の研究課題番号 |
21H01253 (2021-2023)
|
|---|
| 研究種目 |
基盤研究(B)
|
| 配分区分 | 基金 (2024)
補助金 (2021-2023) |
|---|
| 応募区分 | 一般 |
|---|
| 審査区分 |
小区分19010:流体工学関連
|
|---|
| 研究機関 | 熊本大学 |
|---|
研究代表者 |
ホサノ ハミド 熊本大学, 産業ナノマテリアル研究所, 教授 (00543406)
|
|---|
| 研究分担者 |
秀 拓一郎 北里大学, 医学部, 准教授 (40421820)
|
|---|
| 研究期間 (年度) |
2021-04-01 – 2025-03-31
|
| 研究課題ステータス |
交付 (2024年度)
|
| 配分額 *注記 |
16,510千円 (直接経費: 12,700千円、間接経費: 3,810千円)
2024年度: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円)
2023年度: 3,900千円 (直接経費: 3,000千円、間接経費: 900千円)
2022年度: 4,030千円 (直接経費: 3,100千円、間接経費: 930千円)
2021年度: 4,810千円 (直接経費: 3,700千円、間接経費: 1,110千円)
|
|---|
| キーワード | ワクチン/ドラッグデリバリー / マイクロフルイディクス / バイオエンジニアリング |
|---|
| 研究開始時の研究の概要 |
We will design, examine, and elucidate mechanisms/effectiveness of needleless, pain-free, inexpensive, small, controllable microjet vaccine/drug delivery systems. The main advantages are that they can be accurately controlled to deliver required amount of vaccine/drug to exact depth of dermis.
|
| 研究実績の概要 |
The goal of the research for year 2022 (R 4) was defined as investigation of nanosecond-pulsed-electric-field induced cavitation/shock wave streaming microjet; quantitative evaluation of in-vitro and ex-vivo deliveries; and publication.
According to the plan, electrodes with minimize erosion and appropriate nozzle configuration for nanosecond pulse discharge microjet delivery were designed and tested. The ultra-high-speed real-time highly magnified optical setup, which was constructed last year, was used to evaluate the microfluidic and flow physics of the electric discharge induced microstreaming for different applied energies. A manuscript from results has been prepared for submission to a high impact journal. Experiments were performed to evaluate microjet penetration depth and volume in ex-vivo vaccine/drug deliveries. Experiments have been continued to conjugate new protein nanoparticles to minimize the drug/vaccine volume, a new manuscript from the results has been prepared.
For quantitative evaluation, in-vitro and ex-vivo microscopic visualization of microjets in skin, soft tissue, and tumor models were performed. In-vivo experiments were performed to understand effects of microjet and shock waves microstreaming on cells. The interesting results was published in an article, additional manuscript has been prepared and is under submission. Histological evaluations of ex-vivo samples have been underway.
|
| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
The research has been progressing according to the plan. The goals for the year 2022 (R 4) have been achieved.
|
| 今後の研究の推進方策 |
Based on progress achieved during year 2022 (R 4), measures have been taken for the research to advance as planned. Further publication, international conference presentation, and international collaborations have been planned to advance the research.
|
