| 研究課題/領域番号 |
23K25176
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| 補助金の研究課題番号 |
22H03922 (2022-2023)
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| 研究種目 |
基盤研究(B)
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| 配分区分 | 基金 (2024)
補助金 (2022-2023) |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分90110:生体医工学関連
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| 研究機関 | 千葉大学 |
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研究代表者 |
ゴメスタメス ホセデビツト 千葉大学, フロンティア医工学センター, 准教授 (60772902)
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| 研究分担者 |
兪 文偉 千葉大学, フロンティア医工学センター, 教授 (20312390)
大鶴 直史 新潟医療福祉大学, リハビリテーション学部, 教授 (50586542)
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| 研究期間 (年度) |
2022-04-01 – 2025-03-31
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| 研究課題ステータス |
交付 (2024年度)
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| 配分額 *注記 |
17,940千円 (直接経費: 13,800千円、間接経費: 4,140千円)
2024年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2023年度: 4,810千円 (直接経費: 3,700千円、間接経費: 1,110千円)
2022年度: 11,570千円 (直接経費: 8,900千円、間接経費: 2,670千円)
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| キーワード | Brain Stimulation / Neural Engineering / Computational Biophysics / Deep Stimulation / Brain stimulation / Temporal Stimulation / Medical Imaging / Interferential |
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| 研究開始時の研究の概要 |
Brain stimulation is a therapeutic modality that uses electrical stimulation to control/regulate brain functions. There is high interest in targetting deep brain parts as a potential treatment of neurological disorders using non-invasive electrical stimulation. However, deep brain stimulation is difficult without superficial stimulation. A multiscale electrophysiological model is developed to investigate interferential stimulation as a method for achieving focal stimulation together with experimental measurements.
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| 研究実績の概要 |
We continued the investigation on precise focal deep brain stimulation based on a high-resolution physical model of the human head model for non-invasive brain stimulation. Firstly, the conducted studies demonstrated focal stimulation of deep brain tissues, achieved with reduced co-stimulation through interferential stimulation approach, presenting a marked improvement over conventional methods. Secondly, new insights were gained for deep cortical stimulation of the lower limb during dual-hemisphere stimulation protocol. Finally, progress was made in the development of micro-physical neuron model to investigate further interferential phenomena.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The developed personalized computational physical model for investigating focal and deep brain stimulation characteristics is in place. Simulation and experiments were conducted showing the feasibility of focal and deep stimulation providing a better understanding of the characteristics of the generated electric currents in the brain in terms of focality and depth. The model integrated the micro-physical brain neuron to investigate independent kilohertz stimulation and a combination of two-kilohertz stimulation (i.e., interferential stimulation) for further characterization of deep and focal brain stimulations. Publications in recognized journals and top conferences in the field demonstrate the progress of the work.
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| 今後の研究の推進方策 |
In FY2024, we will conduct an extended revision of stimulation parameters to optimize individualized-level and population-level focal deep brain stimulation. The multiscale electrophysiological model will undergo further refinement to explore focal and deep stimulation mechanisms, particularly focusing on high-frequency brain modulation. This will be grounded on mechanisms of high-frequency stimulation through experiments on the peripheral nervous system.
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