| 研究課題/領域番号 |
23K27432
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| 補助金の研究課題番号 |
23H02741 (2023)
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| 研究種目 |
基盤研究(B)
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| 配分区分 | 基金 (2024)
補助金 (2023) |
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| 応募区分 | 一般 |
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| 審査区分 |
小区分50010:腫瘍生物学関連
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| 研究機関 | 東北大学 |
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研究代表者 |
Rashad Sherif 東北大学, 医工学研究科, 准教授 (00824088)
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| 研究分担者 |
遠藤 俊毅 東北医科薬科大学, 医学部, 教授 (00535370)
七谷 圭 東北大学, 未来型医療創成センター, 助教 (00547333)
新妻 邦泰 東北大学, 医工学研究科, 教授 (10643330)
金森 政之 東北大学, 医学系研究科, 准教授 (60420022)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| 研究課題ステータス |
交付 (2024年度)
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| 配分額 *注記 |
18,720千円 (直接経費: 14,400千円、間接経費: 4,320千円)
2025年度: 6,110千円 (直接経費: 4,700千円、間接経費: 1,410千円)
2024年度: 5,980千円 (直接経費: 4,600千円、間接経費: 1,380千円)
2023年度: 6,630千円 (直接経費: 5,100千円、間接経費: 1,530千円)
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| キーワード | tRNA / Glioma / Codon bias / mRNA translation / Ferroptosis |
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| 研究開始時の研究の概要 |
tRNA modifications were shown to impact cancer pathophysiology. Here, using high throughput mass spectrometry coupled to sequencing analysis, we will identify target tRNA modifications that can be further explored for glioma therapy.
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| 研究実績の概要 |
During the past year, I was able to finish 2 manuscripts related to tRNA modifications and their potential role. The manuscripts were published as preprints and currently are under review (Al-Mesitef et al, 2024; Rashad et al, 2024). I also presented the preliminary results of my work in the RNA society meeting 2023 in Singapore and The American Society for Cell Biology 2023 in Boston. I was also able to improve the mass spectrometry method and analyze patient derived glioma samples that led to major discovery in terms of tRNA modifications and glioma that is currently being explored.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Analysis of patient drived glioma samples revealed many tRNA modifications of interest that will be systematically targeted in the next stage. The progress in the analysis of ALKBH1 in glioma is going smoothly and a manuscript is expected to be prepared this year. Structural studies are underway.
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| 今後の研究の推進方策 |
The orignal plan will continue with expansion to a number of tRNA modifications based on the analysis conducted.
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