| 研究開始時の研究の概要 |
Senescent cancer stem cells (CSCs) are thought to be therapeutic-resistant, leading to long-term recurrence and metastasis. In this study, we will confirm whether senescent CSCs return to a proliferative state. Then, we will investigate the changes of mitophagy in the reversal of senescent CSCs. Finally, we will investigate the potential role and the detailed mechanism of mitophagy in regulating the reversal of senescent CSCs and senescence-induced stemness of CSCs, further developing novel therapeutic strategies/approaches for cancers.
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