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ヒトの時間知覚メカニズムにおける2つのドーパミンシステムの役割の検証

研究課題

研究課題/領域番号 23KJ1880
研究種目

特別研究員奨励費

配分区分基金
応募区分国内
審査区分 小区分10040:実験心理学関連
研究機関慶應義塾大学

研究代表者

廣康 衣里紗まり  慶應義塾大学, 文学部(三田), 特別研究員(PD)

研究期間 (年度) 2023-04-25 – 2026-03-31
研究課題ステータス 交付 (2023年度)
配分額 *注記
4,550千円 (直接経費: 3,500千円、間接経費: 1,050千円)
2025年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円)
2024年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
2023年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
キーワードDopamine / Parkinson's disease / Timing
研究開始時の研究の概要

First, I will be investigating whether modality dependent temporal dysfunctions is observed in clinical patients (Study 1). Then, I plan to investigate whether differences in temporal cognition of patients stem from the sensory cortices by seeing whether there is modality, as well as attentional differences, in neural signals of patients with varying degrees of positive symptoms of schizophrenia (Study 2). Last, I plan to investigate whether patients with SZ and healthy controls have differences in neural signatures of temporal regularity when processing of rhythmic stimuli (Study 3)

研究実績の概要

My main focus this year was to identify predictors of finger tapping (spontaneous and subjective pacing of one-second) in both Parkinson's patients (PD) and healthy control patients. Results showed that the Trail Making Task part A (TMT-A) could be a better cognitive measure than the Montreal Cognitive Assessment (MoCA) in predicting finger tapping. This paper is now in preparation for getting published. As for my study about explicit and implicit timing, I have written the program for the data collection with PD patients, presented to the doctors that I will be collaborating with, and gotten IRB ethical approval for collecting data at Showa University Hospital.

現在までの達成度 (区分)
現在までの達成度 (区分)

3: やや遅れている

理由

This year, the progress on my project about explicit and implicit timing in Parkinson's disease has been slower than expected due to delays in collaboration. Sorting out the schedule with the doctors who I am collaborating with, and getting the IRB ethical review board to approve my experiments to be conducted with Parkinson's patients took more time than I had planned.

今後の研究の推進方策

Now that I have gotten the IRB ethical approval at Showa University Hospital, data collection will begin. I will be recruiting approximately 60 patients with Parkinson's disease. Moreover, once I know that the planned experiment works with patients with Parkinson's disease, and no modifications is needed for the script, I will also be collecting data from an age-matched healthy control group at Keio University. Moreover, I will be collaborating with other researchers for other experiments about pre-pulse inhibition in patients with Parkinson's disease.

報告書

(1件)
  • 2023 実施状況報告書
  • 研究成果

    (2件)

すべて 2023

すべて 雑誌論文 (1件) (うち国際共著 1件、 査読あり 1件、 オープンアクセス 1件) 学会発表 (1件) (うち国際学会 1件)

  • [雑誌論文] Longitudinal analysis of social isolation effects on finger tapping in the Blursday database2023

    • 著者名/発表者名
      Gallego Hiroyasu Elisa M.、Laje Rodrigo、Nomura Keishi、Spiousas Ignacio、Hayashi Masamichi J.、Yotsumoto Yuko
    • 雑誌名

      Scientific Reports

      巻: 13 号: 1 ページ: 11277-11277

    • DOI

      10.1038/s41598-023-38488-w

    • 関連する報告書
      2023 実施状況報告書
    • 査読あり / オープンアクセス / 国際共著
  • [学会発表] What does the Blursday Database, collected online, reveal about temporal cognition during the COVID-19 pandemic?2023

    • 著者名/発表者名
      Gallego Hiroyasu, E.M., Laje, R., Nomura, K., Spiousas, I. Hayashi, M.J., & Yotsumoto, Y.
    • 学会等名
      Timing Research Forum
    • 関連する報告書
      2023 実施状況報告書
    • 国際学会

URL: 

公開日: 2023-04-26   更新日: 2024-12-25  

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