ＨＣＶ培養系を用いたＩ型・ＩＩＩ型インターフェロン不応性機構の解析

• 研究課題/領域番号: 24590960
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 消化器内科学
• 研究機関: 東京医科歯科大学
• 研究代表者: 大岡 真也 東京医科歯科大学, 医歯(薬)学総合研究科, 特任准教授 (90361691)
• 研究分担者: 朝比奈 靖浩 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (00422692) ; 渡辺 守 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
• 連携研究者: 坂本 直哉 北海道大学, 医学研究科, 教授 (10334418)
• 研究期間 (年度): 2012-04-01 – 2015-03-31
• 研究課題ステータス: 完了 (2014年度)
• 配分額: 5,460千円 (直接経費: 4,200千円、間接経費: 1,260千円); 2014年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2013年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2012年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
• キーワード: ＨＣＶ / インターフェロン / ＮＳ4Ｂ / ＩＬ28Ｂ / HCV / Cardif / IFNλ / IL-6

研究成果の概要

HCVに対する新規DAA製剤導入後も宿主のインターフェロン不応性は難治の主因となる。本研究では、HCV-NS4BとRIG-I依存性IFN発現経路のシグナル分子であるSTINGとの蛋白相互作用の解析を行い、NS4B蛋白がSTINGに直接結合し、Cardif/STING間の結合を遮断することによってNS3/4Aとは独立かつ協調的にRIG-I依存性IFN-β活性化シグナルを抑制する事を明らかにした。またDAA治療における難治例では、Ｉ型・III型IFN応答系を抑制するSOCS3の上流分子であるIL6が高発現し、III型IFN (IL28B) のSNPが強く関連することを見出した。

研究成果

• [雑誌論文] Impaired induction of IL28B and expression of IFNλ4 associated with non-response to interferon-based therapy in chronic hepatitis C. (2015)
  • 著者名/発表者名: Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M
  • 雑誌名: J Gastroenterol Hepatol 巻: 印刷中 号: 6 ページ: 1075-84
  • DOI: 10.1111/jgh.12902
  • 査読あり / オープンアクセス
• [雑誌論文] Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions. (2015)
  • 著者名/発表者名: Suda G, Yamamoto Y, Nagasaka A, Furuya K, Kudo M, Chuganji Y, Tsukuda Y, Tsunematsu S, Sato F, Terasita K, Nakai M, Horimoto H, Sho T, Natsuizaka M, Ogawa K, Ohnishi S, Chuma M, Fujita Y, Abe R, Taniguchi M, Nakagawa M, Asahina Y, Sakamoto N
  • 雑誌名: Hepatol Res 巻: 印刷中 号: 8 ページ: 837-45
  • DOI: 10.1111/hepr.12421
  • NAID: 120005820706
  • 査読あり / オープンアクセス / 謝辞記載あり
• [雑誌論文] Hepatocellular carcinoma risk assessment using gadoxetic acid-enhanced hepatocyte phase magnetic resonance imaging. (2015)
  • 著者名/発表者名: Komatsu N, Motosugi U, Maekawa S, Shindo K, Sakamoto M, Sato M, Tatsumi A, Miura M, Amemiya F, Nakayama Y, Inoue T, Fukasawa M, Uetake T, Ohtaka M, Sato T, Asahina Y, Kurosaki M, Izumi N, Ichikawa T, Araki T, Enomoto N.
  • 雑誌名: Hepatol Res 巻: - 号: 13 ページ: 1339-1346
  • DOI: 10.1111/hepr.12309
  • 査読あり
• [雑誌論文] Risk factors for exceeding the Milan criteria after successful radiofrequency ablation in patients with early stage hepatocellular carcinoma. (2014)
  • 著者名/発表者名: Tsuchiya K, Asahina Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Kurosaki M, Enomoto N, Izumi N.
  • 雑誌名: Liver Transpl 巻: 20 ページ: 291-297
  • 査読あり / 謝辞記載あり
• [雑誌論文] Reduced organic anion transporter expression is a risk factor for hepatocellular carcinoma in chronic hepatitis C patients. (2014)
  • 著者名/発表者名: Yasui Y, Kudo A, Kurosaki M, Matsuda S, Muraoka M, Tamaki N, Suzuki S, Hosokawa T, Ueda K, Matsunaga K, Nakanishi H, Tsuchiya K, Itakura J, Takahashi Y, Tanaka S, Asahina Y, Enomoto N, Arii S, Izumi N.
  • 雑誌名: Oncology 巻: 86(1) 号: 1 ページ: 53-62
  • DOI: 10.1159/000356643
  • 査読あり
• [雑誌論文] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia. (2014)
  • 著者名/発表者名: Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, （省略）, Tokunaga K, and Mizokami M
  • 雑誌名: PLoS One 巻: 9 号: 2 ページ: e86449-e86449
  • DOI: 10.1371/journal.pone.0086449
  • 査読あり / オープンアクセス
• [雑誌論文] Prospective comparison of real-time tissue elastography and serum fibrosis markers for the estimation of liver fibrosis in chronic hepatitis C patients. (2014)
  • 著者名/発表者名: Tamaki N, Kurosaki M, Matsuda S, Nakata T, Muraoka M, Suzuki Y, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Takahashi Y, Matsunaga K, Taki K, Asahina Y, Izumi N.
  • 雑誌名: Hepatol Res 巻: 44 号: 7 ページ: 720-727
  • DOI: 10.1111/hepr.12179
  • 査読あり
• [雑誌論文] JSH Guidelines for the Management of Hepatitis B Virus Infection (2014)
  • 著者名/発表者名: Asahina Y, HayashinN, Hiramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H, Yotsuyanagi H.
  • 雑誌名: Hepatol Res 巻: 44 号: SUPPL1 ページ: 1
  • DOI: 10.1111/hepr.12269
  • 査読あり
• [雑誌論文] JSH Guidelines for the Management of Hepatitis C Virus Infection: A 2014 Update for Genotype 1 (2014)
  • 著者名/発表者名: Asahina Y, HayashinN, Hiramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H, Yotsuyanagi H.
  • 雑誌名: Hepatol Res 巻: 44 号: SUPPL1 ページ: 59
  • DOI: 10.1111/hepr.12272
  • 査読あり
• [雑誌論文] Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma. (2013)
  • 著者名/発表者名: Tsuchiya K, Asahina Y, Matsuda S, Muraoka M, Nakata T, Suzuki Y, Tamaki N, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N.
  • 雑誌名: Cancer. 巻: 15;120(2) 号: 2 ページ: 229-237
  • DOI: 10.1002/cncr.28384
  • 査読あり
• [雑誌論文] Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy: evaluation by near infrared spectroscopy. (2013)
  • 著者名/発表者名: Nakanishi H,Asahina Y, Izumi N et al
  • 雑誌名: Hepatol Res 巻: in press 号: 3 ページ: 319-326
  • DOI: 10.1111/hepr.12127
  • 査読あり
• [雑誌論文] α-fetoprotein levels afterinterferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C (2013)
  • 著者名/発表者名: Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M,Izumi N
  • 雑誌名: Hepatology 巻: (in press) 号: 4 ページ: 1253-1262
  • DOI: 10.1002/hep.26442
  • 査読あり
• [雑誌論文] Guidelines for the Management of Hepatitis C Virus Infection: First edition, May 2012, The Japan Society of Hepatology Guidelines for the Management of Hepatitis C Virus Infection: First edition, May 2012, The Japan Society of Hepatology (2013)
  • 著者名/発表者名: Asahina Y, Hayashi N, Izumi N, Koike K, Kumada H, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tsubouchi H, Yotsuyanagi H: editors of the Drafting Committee for Hepatitis Management Guidelines.
  • 雑誌名: Hepatol Res 巻: 43 号: 1 ページ: 1
  • DOI: 10.1111/hepr.12020
  • URL: https://pure.teikyo.jp/en/publications/e2e3698a-ca6c-457e-8394-cb4726cf0cf7
  • 査読あり
• [雑誌論文] Inhibition of hepatocellular carcinoma by PegIFNα2a in patients with chronic hepatitis C: a nationwide multi-center cooperative study. (2013)
  • 著者名/発表者名: Izumi N, Asahina Y, Kumada H et al
  • 雑誌名: J Gastroenterol 巻: 48 号: 3 ページ: 382-390
  • DOI: 10.1007/s00535-012-0641-9
  • 査読あり
• [雑誌論文] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity (2013)
  • 著者名/発表者名: Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, asahina Y, Yoneyama M, Fujita T, Watanabe M
  • 雑誌名: Hepatology 巻: 57 号: 1 ページ: 46-58
  • DOI: 10.1002/hep.26017
  • 査読あり
• [雑誌論文] Wnt5a Signaling Mediates Biliary Differentiation of Fetal Hepatic Stem/Progenitor Cells (2013)
  • 著者名/発表者名: Kakinuma S, Kiyohashi K, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, YoshinoK, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, and *WatanabeM
  • 雑誌名: Hepatology 巻: (in press) 号: 6 ページ: 2502-2513
  • DOI: 10.1002/hep.26293
  • 査読あり
• [雑誌論文] Clinical Characteristics of Patients who Developed Hepatocellular Carcinoma after Hepatitis C Virus Eradication with Interferon Therapy: Current Status in Japan (2013)
  • 著者名/発表者名: Sato A, SataM, Ikeda K, Kumada T, Izumi N, Asahina Y, Osaki Y, Chayama K, Kaneko S, Sakai A, Onji M, Hiasa Y, Omura T, Ozeki I, Yokosuka O, Shiina S, Itsubo M, Nishiguchi S, Hirano K, Ide T, Sakisaka S, Yamasaki T, Hidaka I, Tanaka M, Kim SR, Ichida T.
  • 雑誌名: Internal Medicine 巻: 52 号: 24 ページ: 2701-2706
  • DOI: 10.2169/internalmedicine.52.1180
  • NAID: 130003383756
  • ISSN: 0918-2918, 1349-7235
  • 査読あり
• [雑誌論文] Noninvasive estimation of fibrosis progression overtime using the FIB-4 index in chronic hepatitis C. (2013)
  • 著者名/発表者名: Tamaki N, Asahina Y, Izumi N et al
  • 雑誌名: J Viral Hepat 巻: 20 号: 1 ページ: 72-76
  • DOI: 10.1111/j.1365-2893.2012.01635.x
  • 査読あり
• [雑誌論文] Virological response and safety of 24-week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b. (2013)
  • 著者名/発表者名: Toyota J, Asahina Y, Kumada H et al
  • 雑誌名: J Viral Hepat 巻: 20 号: 3 ページ: 167-173
  • DOI: 10.1111/j.1365-2893.2012.01640.x
  • 査読あり
• [雑誌論文] Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells (2013)
  • 著者名/発表者名: Kiyohashi K
  • 雑誌名: Hepatology 巻: in press
  • 査読あり
• [雑誌論文] α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C (2013)
  • 著者名/発表者名: Asahina Y
  • 雑誌名: Hepatology 巻: in press
  • 査読あり
• [雑誌論文] Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy: evaluation by near infrared spectroscopy (2013)
  • 著者名/発表者名: Nakanishi H
  • 雑誌名: Hepatol Res 巻: in press
  • 査読あり
• [雑誌論文] No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations. (2012)
  • 著者名/発表者名: Sawai H, Asahina Y, Tokunaga K et al
  • 雑誌名: BMC Med Genet 巻: 13 号: 1 ページ: 47-47
  • DOI: 10.1186/1471-2350-13-47
  • 査読あり
• [雑誌論文] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. (2012)
  • 著者名/発表者名: Nishida N, Asahina Y, Mizokami M et al
  • 雑誌名: PLoS One 巻: 7 号: 6 ページ: 1-8
  • DOI: 10.1371/journal.pone.0039175
  • 査読あり
• [雑誌論文] Randomized phase IIstudy of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Oeganization PC-01 study) (2012)
  • 著者名/発表者名: Ozaka M
  • 雑誌名: Cancer Chemother Pharmacol 巻: 69 号: 5 ページ: 1197-1204
  • DOI: 10.1007/s00280-012-1822-1
  • 査読あり
• [雑誌論文] Association of gene expression involving innate immunity and genetic variation in IL28B with antiviral response (2011)
  • 著者名/発表者名: Asahina Y, Sakamoto N, et al
  • 雑誌名: Hepatology 巻: 55(1) 号: 1 ページ: 20-29
  • DOI: 10.1002/hep.24623
  • 査読あり
• [学会発表] Gene Alterations in TERT promoter, CTNNB1, and TP53 are closely associated with development and prognosis of hepatocellular carcinoma: comprehensive analyses by next generation sequencing technology. (2015)
  • 著者名/発表者名: Asahina Y, Kawai-Kitahata F, Kaneko S, Nagata H, Goto F, Otani S, Taniguchi M, Murakawa M, Nitta S, Watanabe T, Tasaka-Fujita M, Itsui Y, Nakagawa M, Kakinuma S, Tanaka S, Tanabe M, Enomoto N, Watanabe M.
  • 学会等名: he 50th annual meeting of the European association for the study of the liver (EASL The International Liver Congress 2015)
  • 発表場所: Vienna, Austria
  • 年月日: 2015-04-23
• [学会発表] Gene alterations in β-catenin and p53/ cell cycle control pathway are closely associated with development and prognosis of hepatocellular carcinoma: Comprehensive analyses by next generation sequencing technology. (2014)
  • 著者名/発表者名: Kawai-Kitahata F, Asahina Y, Kaneko S, Nagata H, Goto F, Otani S, Taniguchi M, Murakawa M, Nitta S, Watanabe T, Tasaka-Fujita M, Itsui Y, Nakagawa M, Kakinuma S, Enomoto N, Watanabe M.
  • 学会等名: The 65th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2014)
  • 発表場所: Boston, USA
  • 年月日: 2014-11-07 – 2014-11-11
• [学会発表] Matrix Metalloproteinase-14 regulates the maturation of fetal hepatic stem/progenitor cells in mice. (2014)
  • 著者名/発表者名: Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M.
  • 学会等名: The 65th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2014)v
  • 発表場所: Boston, USA
  • 年月日: 2014-11-07 – 2014-11-11
• [学会発表] Impact of host and therapeutic factors and resistant associated variants on response to interferon based- direct acting antiviral treatment in difficult-to-treat chronic hepatitis C patients. (2014)
  • 著者名/発表者名: Nakagawa M, Asahina Y, Taniguchi M, Watanabe T, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Watanabe M.
  • 学会等名: The 65th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2014)
  • 発表場所: Boston, USA
  • 年月日: 2014-11-07 – 2014-11-11
• [学会発表] Expression of IFN/.4 in liver and PBMC is closely associated with higher basal expression of ISGs and impaired induction of IL28B by interferon treatment in chronic hepatitis C non-responder patients. (2014)
  • 著者名/発表者名: Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kawai-Kitahata F, Taniguchi M, Watanabe T, Itsui Y, Kakinuma S, Watanabe M.
  • 学会等名: The 65th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2014)
  • 発表場所: Boston, USA
  • 年月日: 2014-11-07 – 2014-11-11
• [学会発表] Emergence or selection of resistant associated variant immediately after initiation of the therapy is predictive for failure of direct acting antiviral therapy: ultra-deep sequencing analyses for serial time points. (2014)
  • 著者名/発表者名: Watanabe T, Asahina Y, Nakagawa M, Kakinuma S, YItsui Y, Taniguchi T, Murakawa M, Nagata H, Miura M, Maekawa S, Enomoto E, Watanabe M.
  • 学会等名: The 65th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2014)
  • 発表場所: Boston, USA
  • 年月日: 2014-11-07 – 2014-11-11
• [学会発表] Clinical outcomes in patients who develop hepatocellular carcinoma after hepatitis C viral eradication by antiviral therapy. (2014)
  • 著者名/発表者名: Tsuchiya K, Yasui Y, Tamaki N, Suzuki S, Hosokawa T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Asahina Y, Izumi N.
  • 学会等名: The 65th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2014)
  • 発表場所: Boston, USA
  • 年月日: 2014-11-07 – 2014-11-11
• [学会発表] Associations of HLA-DPB1 with CHB infection and HBV related HCC in Asia. (2014)
  • 著者名/発表者名: Nishida N, Sawai H, Asahina Y, Mizokami M, et al.
  • 学会等名: The 65th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2014)
  • 発表場所: Boston, USA
  • 年月日: 2014-11-07 – 2014-11-11
• [学会発表] Impaired IL28B gene induction and expression of IFNλ4 influenced by the polymorphisms near IL28B gene are closely associated with a non-response to interferon in chronic hepatitis C patients. (2014)
  • 著者名/発表者名: Asahina Y, Murakawa M, NittaS, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Watanabe M.
  • 学会等名: The 49th annual meeting of the European association for the study of the liver (EASL The International Liver Congress 2014)
  • 発表場所: London, UK
  • 年月日: 2014-04-08 – 2014-04-14
• [学会発表] Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid magnetic resonance imaging and contrast enhanced ultrasonography with sonazoid as part of therapeutic strategies for small nonhypervascular hepatic nodular lesions. (2014)
  • 著者名/発表者名: Tsuchiya K, Yasui Y, Takada N, Nakakuki S, Matsuda S, Kaneko S, Muraoka M, Yamashita N, Hattori N, Tamaki N, Osaki S, Suzuki T, Hosokawa K, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Asahina Y, Izumi N.
  • 学会等名: The 49th annual meeting of the European association for the study of the liver (EASL The International Liver Congress 2014)
  • 発表場所: London, UK
  • 年月日: 2014-04-08 – 2014-04-14
• [学会発表] Serum interleukin-6 levels during treatment correlate with resistance to telaprevir-based triple therapy in chronic hepatitis C (2013)
  • 著者名/発表者名: Asahina Y, Nakagawa M, Taniguchi M, Kawai F, Fujiki J, Otani T, Yamanaka H, Murakawa M, Nitta S, Kitazume A, Watanabe T, Sakurai Y, Azuma S, Kakinuma S, Watanabe M.
  • 学会等名: The 48th annual meeting of the European association for the study of the liver (EASL The International Liver Congress 2013)
  • 発表場所: Amusterdam(Netherlands)
• [学会発表] Substitution of amino acid 70/91 in the hepatitis C virus core region affects infectious virus production and cell surface expression of MHC class I. (2013)
  • 著者名/発表者名: Tasaka-Fujita M, Sugiyama N, Kang W, Murayama A, Asahina Y, Sakamoto N, Wakita T, Shin EC, Kato T.
  • 学会等名: The 64th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2013)
  • 発表場所: Washington DC(USA)
• [学会発表] Impaired IL28B gene induction and expression of IFNλ4 are closely associated with a non-response to interferon-based therapy in chronic hepatitis C patients. (2013)
  • 著者名/発表者名: Asahina Y, Murakawa M, NittaS, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Watanabe M.
  • 学会等名: The 64th Annual Meeting of the American Association for the Study of Liver Disease (AASLD The Liver Meeting 2013)
  • 発表場所: Washington DC(USA)
• [学会発表] Serum interleukin-6 levels during treatment correlate with resistance to telaprevir-based triple therapy in chronic hepatitis C (2013)
  • 著者名/発表者名: Asahina Y
  • 学会等名: EASL: The international liver congress 2013
  • 発表場所: Amsterdam
• [学会発表] Supression of Alpha-fetoprotein by Interferon Therapy Reduces The Risk of Hepatocarcinogenesis in Patients with Chronic Hepatitis C (2012)
  • 著者名/発表者名: Asahina Y
  • 学会等名: EASL: The international liver congress 2012
  • 発表場所: Barelona
• [学会発表] Association of Gene Expression Involving Innate Immunity and IFN Signaling with Genetic Variation in IL28B in Patients with Chronic Hepatitis C. (2012)
  • 著者名/発表者名: Asahina Y
  • 学会等名: The 10th JSH Single Topic Conference
  • 発表場所: Tokyo
  • 招待講演
• [学会発表] HCV-NS4B Protein Binds STING and Blocks the RIG-I Mediated IFN Pathway. (2012)
  • 著者名/発表者名: Nitta S
  • 学会等名: The 10th JSH Single Topic Conference
  • 発表場所: Tokyo
• [学会発表] Discovery of N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication. (2012)
  • 著者名/発表者名: Akiko Kusano-Kitazume
  • 学会等名: The 10th JSH Single Topic Conference
  • 発表場所: Tokyo
• [学会発表] Impaired induction of IL28B expression in PBMC is associated with null response to interferon therapy in chronic hepatitis C. (2012)
  • 著者名/発表者名: Murakawa M
  • 学会等名: 19th International Symposium on Hepatitis C Virus and Related Viruses
  • 発表場所: Venice
• [学会発表] HCV-NS4B blocks the RIG-I mediated IFN pathway through targeting of STING. (2012)
  • 著者名/発表者名: Nitta S
  • 学会等名: 19th International Symposium on Hepatitis C Virus and Related Viruses
  • 発表場所: Venice
• [学会発表] Imparied IL28B gene induction and poor IL28B promoter activity influenced by the IL28B minor allele are closely associated with a null response to interferon in chronic hepatitis C patients. (2012)
  • 著者名/発表者名: Asahina Y
  • 学会等名: AASLD The Liver Meeting 2012
  • 発表場所: Boston
• [学会発表] Risk factors for exceeding the Milan criteria following successful radiofrequency ablation in patients with early stage hepatocellular carcinoma: determination of patients requiring early transplantation or new adjuvant therapy (2012)
  • 著者名/発表者名: Tsuchiya K
  • 学会等名: AASLD The Liver Meeting 2012
  • 発表場所: Boston
• [学会発表] Reduced organic anion transporter 2 expression is associated with a high risk for hepatocellulare carcinoma in chronic hepatitis C patients: a propensity score-matched study. (2012)
  • 著者名/発表者名: Yasui Y
  • 学会等名: AASLD The Liver Meeting 2012
  • 発表場所: Boston
• [学会発表] Antiviral effects and action mechanisms of novel N-(morpholine-4-carbonyloxy) amidine compaunds against hepatitis C virus. (2012)
  • 著者名/発表者名: Kusano-Kitazume A
  • 学会等名: AASLD The Liver Meeting 2012
  • 発表場所: Boston
• [図書] 肝癌治療実践のKnack & Pitfalls RFAのoutcome診療ガイドラインに沿った肝癌治療の要点と盲点 (2013)
  • 著者名/発表者名: 高山忠利、泉並木、朝比奈靖浩
  • 出版者: 文光堂
• [図書] 肝臓病診療 ゴールデンハンドブック 改訂第2版 (2013)
  • 著者名/発表者名: 泉並木、朝比奈靖浩
  • 出版者: 南江堂
• [図書] 肝炎ウイルスーB型・C型 (2012)
  • 著者名/発表者名: 熊田博光、朝比奈靖浩
  • 出版者: 医薬ジャーナル社
• [図書] 臨床検査のガイドライン (2012)
  • 著者名/発表者名: 日本臨床検査医学会ガイドライン作成委員会、朝比奈靖浩
  • 出版者: 株式会社宇宙堂八木書店