分子進化から予測される新規インターフェロン誘導経路

• 研究課題/領域番号: 24659214
• 研究種目: 挑戦的萌芽研究
• 配分区分: 補助金
• 研究分野: 免疫学
• 研究機関: 北海道大学
• 研究代表者: 瀬谷 司 北海道大学, 医学(系)研究科(研究院), 教授 (10301805)
• 研究期間 (年度): 2012-04-01 – 2014-03-31
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 3,900千円 (直接経費: 3,000千円、間接経費: 900千円); 2013年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円); 2012年度: 1,950千円 (直接経費: 1,500千円、間接経費: 450千円)
• キーワード: 自然免疫 / パターン認識レセプター / インターフェロン

研究概要

細胞外にIg ドメイン、細胞内にToll-IL-1 homology domain (TIR)を持つ1型膜蛋白質Ig-TIRをサカナ(zebrafish database)で2種同定し、cDNA cloning した。Overexpression とsiRNAでその自然免疫パターン認識分子としての機能を調べたが、予想に反してNF-kB活性化、IFN誘導、サイトカイン誘導のどれも検知できなかった。本分子群はTLRのようなパターン認識機能ではない別な機能を担う分子と想定された。

研究成果

• [雑誌論文] IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection (2014)
  • 著者名/発表者名: Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T.
  • 雑誌名: J Immunol 巻: (Epub ahead of print)
• [雑誌論文] Beyond dsRNA : Toll-like receptor 3 signalling in RNA-induced immune responses (2014)
  • 著者名/発表者名: Tatematsu M, Seya T, Matsumoto M.
  • 雑誌名: Biochem J 巻: 458(2) ページ: 195-201
• [雑誌論文] MAVS-dependent IRF3/7 bypass of interferonβ-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells (2014)
  • 著者名/発表者名: Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T.
  • 雑誌名: Mol Immunol 巻: 57(2) ページ: 100-10
• [雑誌論文] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic : polycytidylic acid treatment in mouse tumor models (2014)
  • 著者名/発表者名: Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T.
  • 雑誌名: J Innate Immun 巻: 6 ページ: 293-305
• [雑誌論文] Assessment of the Toll-like receptor 3 pathway in endosomal signaling (2014)
  • 著者名/発表者名: Matsumoto M, Funami K, Tatematsu M, Azuma M, Seya T.
  • 雑誌名: Methods Enzymol 巻: 535 ページ: 149-65
• [雑誌論文] IPS-1 Is Essential for Type III IFN Production by Hepetocytes and bendritic Cells in Response to Hepatitis C Virus Infection. (2014)
  • 著者名/発表者名: Masaaki Okamoto, et al.
  • 雑誌名: Journal of immunology 巻: 192 号: 6 ページ: 2770-7
  • DOI: 10.4049/jimmunol.1301459
  • 査読あり
• [雑誌論文] Beyond double-stranded RNA : TLR3 signaling in RNA-induced immune responses (2014)
  • 著者名/発表者名: Tatematsu, M., T. Seya, M. Matsumoto
  • 雑誌名: Biochem. J 巻: 458 号: 2 ページ: 195-201
  • DOI: 10.1042/bj20131492
  • 査読あり
• [雑誌論文] MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Ta mouse bone marrow-derived dendritic cells. (2014)
  • 著者名/発表者名: Hiromi Takaki, et al.
  • 雑誌名: Molecular Immunology 巻: 57 号: 2 ページ: 100-110
  • DOI: 10.1016/j.molimm.2013.08.007
  • 査読あり
• [雑誌論文] Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA (2013)
  • 著者名/発表者名: Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T.
  • 雑誌名: PLoS One 巻: 8(12)
  • NAID: 120005372326
• [雑誌論文] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling (2013)
  • 著者名/発表者名: Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
  • 雑誌名: Proc Natl Acad Sci U S A 巻: 110(49) ページ: 19908-13
• [雑誌論文] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model (2013)
  • 著者名/発表者名: Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.
  • 雑誌名: J Immunol 巻: 191(9) ページ: 4740-7
• [雑誌論文] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses (2013)
  • 著者名/発表者名: Oshiumi H, Miyashita M, Matsumoto M, Seya T.
  • 雑誌名: PLoS Pathog 巻: 9(8)
  • NAID: 120005326762
• [雑誌論文] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion (2013)
  • 著者名/発表者名: Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
  • 雑誌名: J Virol 巻: 87(19) ページ: 10900-3
• [雑誌論文] Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells (2013)
  • 著者名/発表者名: Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K.
  • 雑誌名: J Virol 巻: 87 ページ: 8169-78
• [雑誌論文] Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA (2013)
  • 著者名/発表者名: Tatematsu M, Nishikawa F, Seya T, Matsumoto M.
  • 雑誌名: Nat Commun 巻: 4 ページ: 1833-1833
• [雑誌論文] Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer (2013)
  • 著者名/発表者名: Seya T, Azuma M, Matsumoto M.
  • 雑誌名: Expert Opin Ther Targets 巻: 17(5) ページ: 533-44
• [雑誌論文] Multi-step regulation of interferon induction by hepatitis C virus (2013)
  • 著者名/発表者名: Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
  • 雑誌名: Arch Immunol Ther Exp (Warsz) 巻: 61(2) ページ: 127-38
• [雑誌論文] Cleaved/associated TLR3 represents the primary form of the signaling receptor (2013)
  • 著者名/発表者名: Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T, Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
  • 雑誌名: J Immunol 巻: 190(2) ページ: 764-73
• [雑誌論文] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. (2013)
  • 著者名/発表者名: Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
  • 雑誌名: Proc Natl Acad Sci U S A. 巻: 110(49) 号: 49 ページ: 19908-19913
  • DOI: 10.1073/pnas.1222811110
  • 査読あり
• [雑誌論文] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model. (2013)
  • 著者名/発表者名: Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.
  • 雑誌名: J Immunol. 巻: 191(9) ページ: 4740-4747
  • 査読あり
• [雑誌論文] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses. (2013)
  • 著者名/発表者名: Oshiumi H, Miyashita M, Matsumoto M, Seya T.
  • 雑誌名: PLoS Pathog. 巻: 9(8) 号: 8 ページ: e1003533-e1003533
  • DOI: 10.1371/journal.ppat.1003533
  • NAID: 120005326762
  • 査読あり
• [雑誌論文] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion. (2013)
  • 著者名/発表者名: Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
  • 雑誌名: J Virol. 巻: 87(19) 号: 19 ページ: 10900-10903
  • DOI: 10.1128/jvi.01427-13
  • 査読あり
• [雑誌論文] Hepatitis C Virus Infection Induces Inflammatory Cytokines and Chemokines Mediated by the Cross Talk between Hepatocytes and Stellate Cells. (2013)
  • 著者名/発表者名: Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K.
  • 雑誌名: J. Viol 巻: 87 号: 14 ページ: 8169-8178
  • DOI: 10.1128/jvi.00974-13
  • 査読あり
• [雑誌論文] Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA (2013)
  • 著者名/発表者名: Tatematsu, M., F. Nishikawe, T. Seya, M. Matsumoto
  • 雑誌名: Nat Commun. 巻: 4 号: 1 ページ: 1-833
  • DOI: 10.1038/ncomms2857
  • 査読あり
• [雑誌論文] Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer. (2013)
  • 著者名/発表者名: Seya T, Azuma M, Matsumoto M.
  • 雑誌名: Expert Opin Ther Targets. 巻: 17(5) 号: 5 ページ: 533-544
  • DOI: 10.1517/14728222.2013.765407
  • 査読あり
• [雑誌論文] Multi-step regulation of interferon induction by hepatitis C virus. (2013)
  • 著者名/発表者名: Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
  • 雑誌名: Arch Immunol Ther Exp (Warsz) 巻: 61(2) 号: 2 ページ: 127-138
  • DOI: 10.1007/s00005-012-0214-x
  • 査読あり
• [雑誌論文] Cleaved/associated TLR3 represents the primary form of the signaling receptor. (2013)
  • 著者名/発表者名: Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T,Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
  • 雑誌名: J Immunol. 巻: 190(2) 号: 2 ページ: 764-773
  • DOI: 10.4049/jimmunol.1202173
  • 査読あり
• [雑誌論文] Structures and interface mapping of the Toll/Interleukin-1 receptor-domain-containing adaptor molecules involved in interferon signaling. (2013)
  • 著者名/発表者名: Enokizono, Y., H. Kumeta, K. Funami, M. Horiuchi, J. Sarmiento, K. Yamashita, D. Standley, T. Seya, M. Matsumoto, F. Inagaki
  • 雑誌名: Proc Natl Acad Sci USA 巻: 印刷中
  • 査読あり
• [雑誌論文] Riplet ubiquitin ligase plays a pivotal role in TRIM25-mediated RIG-I activation and is targeted by Hepatitis C Virus. (2013)
  • 著者名/発表者名: Oshiumi, H., M. Miyashita, M. Matsumoto, and T. Seya
  • 雑誌名: PLoS Pathog. 巻: 印刷中
  • 査読あり
• [雑誌論文] Toll-like receptor 3 recognizes single-stranded RNA with incomplete stem structures. (2013)
  • 著者名/発表者名: Tatematsu, M., F. Nishikawa, T. Seya, M. Matsumoto.
  • 雑誌名: Nat Commun. 巻: 印刷中
  • 査読あり
• [雑誌論文] TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors (2012)
  • 著者名/発表者名: Shime H, M. Matsumoto, H. Oshiumi, S. Tanaka, A. Nakane, Y. Iwakura, H. Tahara, N. Inoue, and T. Seya.
  • 雑誌名: Proc Natl Acad Sci USA 巻: 109 ページ: 2066-2071
• [雑誌論文] Toll-like receptor 3-mediated antivirus response is important for protection against poliovirus infection in poliovirus receptor transgenic mice (2012)
  • 著者名/発表者名: Abe, Y., K. Fujii, N. Nagata, O. Takeuchi, S. Akira, H. Oshiumi, M. Matsumoto, T. Seya, and S. Koike.
  • 雑誌名: J. Virol 巻: 86 ページ: 185-194
• [雑誌論文] Dendritic cells from oral cavity induce Foxp3+ regulatory T cells upon antigen stimulation (2012)
  • 著者名/発表者名: Yamazaki, S., A. Maruyama, K. Okada, M. Matsumoto, A. Morita, and T. Seya.
  • 雑誌名: PLoS ONE 巻: 7
  • NAID: 120005208896
• [雑誌論文] TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis. (2012)
  • 著者名/発表者名: Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M.
  • 雑誌名: Oncoimmunol. 巻: 1 号: 6 ページ: 917-923
  • DOI: 10.4161/onci.21244
  • NAID: 120005228664
  • 査読あり
• [雑誌論文] TAMable tumor-associated macrophages in response to innate RNA sensing. (2012)
  • 著者名/発表者名: Seya T, Shime H, Matsumoto M.
  • 雑誌名: Oncoimmunol. 巻: 1 号: 6 ページ: 1000-1001
  • DOI: 10.4161/onci.19894
  • NAID: 120005228653
  • 査読あり
• [雑誌論文] Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I (2012)
  • 著者名/発表者名: Oshiumi, H., M.Matsumoto, T.Seya
  • 雑誌名: J.Biochem. 巻: 151 号: 1 ページ: 5-11
  • DOI: 10.1093/jb/mvr111
  • NAID: 10031166037
  • 査読あり
• [雑誌論文] Dendritic cells from oral cavity induce Foxp3^+ regulatory T cells upon antigen stimulation (2012)
  • 著者名/発表者名: Yamazaki S #, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T(#Corresponding author)
  • 雑誌名: PLosOne 巻: 7 号: 12 ページ: 1-9
  • DOI: 10.1371/journal.pone.0051665
  • NAID: 120005208896
  • 査読あり
• [雑誌論文] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors (2012)
  • 著者名/発表者名: H.Shime
  • 雑誌名: Proc Natl Acad Sci USA 巻: 109 号: 6 ページ: 2066-2071
  • DOI: 10.1073/pnas.1113099109
  • 査読あり
• [雑誌論文] The Toll-like receptor 3-mediayed antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice (2012)
  • 著者名/発表者名: Abe, Y., K.Fujii, N.Nagata, O.Takeuchi, S.Akira, H.Oshiumi, M.Matsumoto, T.Seya, S.Koike
  • 雑誌名: J.Virol 巻: 86 号: 1 ページ: 185-194
  • DOI: 10.1128/jvi.05245-11
  • 査読あり
• [雑誌論文] Cross-presentation and antitumor CTL induced by soluble Ag + polyI:C largely depend on the TICAM-1 pathway in mouse CD11c+/CD8a+ dendritic cells. (2012)
  • 著者名/発表者名: Azuma M., T. Ebihara, H. Oshiumi, M. Matsumoto, and T. Seya.
  • 雑誌名: OncoImmunol. 巻: 1 号: 5 ページ: 581-592
  • DOI: 10.4161/onci.19893
  • 査読あり
• [雑誌論文] In vitro models for the analysis of HCV life cycle (2011)
  • 著者名/発表者名: Aly HH, Shimotohno K, Hijikata M, Seya T
  • 雑誌名: Microbiol Immunol 巻: 56 号: 1 ページ: 1-9
  • DOI: 10.1111/j.1348-0421.2011.00403.x
  • 査読あり
• [雑誌論文] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages (2011)
  • 著者名/発表者名: Hazeki, K., Kametani, Y., et al, (11名中7番目)
  • 雑誌名: PLoS One. 巻: 6 号: 10 ページ: e26836-e26836
  • DOI: 10.1371/journal.pone.0026836
  • 査読あり
• [図書] Oligomerization in Health and Diseases. (2013)
  • 著者名/発表者名: Matsumoto, M., K. Funami, H. Oshiumi, and T. Seya
  • 出版者: Academic Press, ELSEVIER INC.
• [備考] HP
  • URL: http://www.hucc.hokudai.ac.jp/~e20536/
• [備考] 免疫学分野のホームページ
  • URL: http://www.hucc.hokudai.ac.jp/~e20536/