細胞の遺伝子発現解析に基づく機能性分子発現系を利用した腫瘍診断薬の設計戦略の検証

• 研究課題/領域番号: 24659558
• 研究種目: 挑戦的萌芽研究
• 配分区分: 基金
• 研究分野: 放射線科学
• 研究機関: 金沢大学
• 研究代表者: 川井 恵一 金沢大学, 保健学系, 教授 (30204663)
• 連携研究者: 玉井 郁巳 金沢大学, 薬学系, 教授 (20155237) ; 岡沢 秀彦 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
• 研究期間 (年度): 2012-04-01 – 2015-03-31
• 研究課題ステータス: 完了 (2014年度)
• 配分額: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円); 2014年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円); 2013年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円); 2012年度: 1,300千円 (直接経費: 1,000千円、間接経費: 300千円)
• キーワード: ヒト培養細胞 / 遺伝子発現解析 / 機能性分子発現系 / ポストＦＤＧ / 腫瘍診断薬 / アミノ酸トランスポータ / 薬物トランスポータ / 設計戦略 / ポストＦＤＧ製剤 / 細胞集積機序 / 腫瘍細胞集積機序

研究成果の概要

本研究では、薬剤評価に用いるヒト培養細胞の遺伝子発現レベルをデータベース化し、癌細胞に高発現している機能性分子を予め探索するとともに、ヒト腫瘍培養細胞で高発現を確認した機能性分子安定発現系を分子プローブのスクリーニングに利用して、ポストFDG製剤の有力候補である標識アミノ酸製剤のアミノ酸トランスポータ及び薬物トランスポータに対する親和性を詳細に検討し、アミノ酸トランスポータ遺伝子発現と腫瘍集積性との相関からその設計戦略の妥当性を検証した。

研究成果

• [雑誌論文] In vivo radioactive metabolite analysis for individualized medicine: a basic study of a new method of CYP activity assay using (123)I-IMP. (2015)
  • 著者名/発表者名: Nishi K, Mizutani A, Shikano N, Fujita K, Kobayashi M, Ono M, Nishii R, Sasaki Y, Kinuya S, Kawai K.
  • 雑誌名: Nucl Med Biol 巻: 2 号: 2 ページ: 171-176
  • DOI: 10.1016/j.nucmedbio.2014.08.015
  • NAID: 120006986250
  • 査読あり / オープンアクセス
• [雑誌論文] A Novel Injection Strategy of Flurbiprofen-axetil by Inhibiting Protein Binding with 6-Methoxy-2-naphthylacetic Acid. (2015)
  • 著者名/発表者名: Ogata K., Takamura N., Tokunaga J., Ikeda T., Setoguchi N., Tanda K,., Yamasaki T., Nishio T., Kawai K.
  • 雑誌名: Eur. J. Drug Metab. Pharmacok. 巻: 40
  • 査読あり
• [雑誌論文] A strategy for improving FDG accumulation for early detection of metastasis from primary pancreatic cancer: Stimulation of the Warburg effect in AsPC-1 cells. (2015)
  • 著者名/発表者名: Ogura M, Shikano N, Nakajima S, Sagara J, Yamaguchi N, Kusanagi K, Okui Y, Mizutani A, Kobayashi M, Kawai K.
  • 雑誌名: Nuclear Medicine and Biology 巻: 42 号: 5 ページ: 475-481
  • DOI: 10.1016/j.nucmedbio.2014.12.017
  • 査読あり / オープンアクセス / 謝辞記載あり
• [雑誌論文] Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma. (2015)
  • 著者名/発表者名: Kobayashi M, Nishii R, Shikano N, Flores LG 2nd, Mizutani A, Ogai K, Sugama J, Nagamachi S, Kawai K.
  • 雑誌名: Nucl Med Biol 巻: 6 号: 6 ページ: 536-540
  • DOI: 10.1016/j.nucmedbio.2015.02.004
  • 査読あり / オープンアクセス
• [雑誌論文] Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan. (2014)
  • 著者名/発表者名: Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K.
  • 雑誌名: Nucl Med Biol 巻: 4 号: 4 ページ: 338-342
  • DOI: 10.1016/j.nucmedbio.2014.01.004
  • 査読あり
• [雑誌論文] Differences in Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic Acid in Inflammatory, Prostate Cancer, and Glioma Cells: Comparison with L-[Methyl-11C]methionine and 2-Deoxy-2-[18F]fluoro-D-glucose. (2014)
  • 著者名/発表者名: Oka S., Okudaira H., Ono M., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
  • 雑誌名: Mol. Imaging Biol. 巻: 16(3) 号: 3 ページ: 322-329
  • DOI: 10.1007/s11307-013-0693-0
  • 査読あり
• [雑誌論文] Performance evaluation of the eXplore speCZT preclinical imaging system. (2014)
  • 著者名/発表者名: Matsunari I, Miyazaki Y, Kobayashi M, Nishi K, Mizutani A, Kawai K, Hayashi A, Komatsu R, Yonezawa R, Kinuya S.
  • 雑誌名: Annuls of Nuclear medicine 巻: 28 号: 5 ページ: 484-497
  • DOI: 10.1007/s12149-014-0828-7
  • 査読あり / 謝辞記載あり
• [雑誌論文] Application of a medium-energy collimator for I-131 imaging after ablation treatment of differentiated thyroid cancer. (2014)
  • 著者名/発表者名: Kobayashi M, Wakabayashi H, Kayano D, Konishi T, Kojima H, Okuda K, Yoneyama H, Tsushima H, Onoguchi M, Kawai K, Kinuya S.
  • 雑誌名: Annuls of Nuclear medicine 巻: 28 号: 6 ページ: 551-558
  • DOI: 10.1007/s12149-014-0845-6
  • 査読あり / 謝辞記載あり
• [雑誌論文] Accumulation of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in prostate cancer due to androgen-induced expression of amino-acid transporters. (2014)
  • 著者名/発表者名: Okudaira H, Oka S, Ono M, Nakanishi T, Shuster DM, Kobayashi M, Goodman MM, Tamai I, Kawai K, Shirakami Y.
  • 雑誌名: Molecular Imaging and Biology 巻: 16 号: 6 ページ: 756-764
  • DOI: 10.1007/s11307-014-0756-x
  • 査読あり / 謝辞記載あり
• [雑誌論文] Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage (2014)
  • 著者名/発表者名: Atsushi Yamashita, Yan Zhao, Yunosuke Matsuura, Kazuaki Yamasaki, Sayaka Moriguchi-Goto, Chihiro Sugita, Takashi Iwakiri, Nozomi Okuyama, Chihiro Koshimoto, Keiichi Kawai, Nagara Tamaki, Songji Zhao, Yuji Kuge, Yujiro Asada
  • 雑誌名: PLos One 巻: 9 号: 1 ページ: e86426-e86426
  • DOI: 10.1371/journal.pone.0086426
  • 査読あり / オープンアクセス
• [雑誌論文] Influences of Artificial Heart-lung Machine Operation on the Binding Sites of Albumin: Possibility of an Effective Administration Plan. (2014)
  • 著者名/発表者名: Totoribe K., Takamura N., Ogata K., Tokunaga J., Kawai K., Nakamura K., Ieiri I., Higuchi S.
  • 雑誌名: Int. J. Artif. Organs 巻: 2(37) 号: 2 ページ: 99-108
  • DOI: 10.5301/ijao.5000299
  • 査読あり
• [雑誌論文] Monitoring of Gefitinib Sensitivity with Radioiodinated PHY based on EGFR Expression. (2014)
  • 著者名/発表者名: Yoshimoto M., Hirata M., Kanai Y., Naka S., Nishii R., Kagawa S., Kawai K., Ohmomo Y.
  • 雑誌名: Biol. Pharm. Bull. 巻: 37(3) ページ: 355-360
  • NAID: 130003390939
  • 査読あり
• [雑誌論文] Differences in Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in Inflammatory, Prostate Cancer, and Glioma Cells: Comparison with L-[Methyl-11C]methionine and [18F]Fluoro-D-deoxy glucose. (2014)
  • 著者名/発表者名: Oka S., Okudaira H., Ono M., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
  • 雑誌名: Mol. Imaging Biol. 巻: 16
  • 査読あり
• [雑誌論文] Appropriate collimators in a small animal SPECT scanner with CZT detector. (2013)
  • 著者名/発表者名: Higaki Y, Kobayashi M, Uehara K, Hanaoka H, Arano Y, Kawai K.
  • 雑誌名: Annals of Nuclear Medicine 巻: 27 号: 3 ページ: 271-278
  • DOI: 10.1007/s12149-012-0681-5
  • NAID: 10031168094
  • 査読あり
• [雑誌論文] Predominant contribution of L-type amino acid transporter to 4-borono-2-18F-fluoro-phenylalanine uptake in human glioblastoma cells (2013)
  • 著者名/発表者名: Yoshimoto M, Kurihara H, Honda N, Kawai K, Ohe K, Fujii H, Itami J, Arai Y.
  • 雑誌名: Nuclear Medicine and Biology 巻: 40 号: 5 ページ: 625-629
  • DOI: 10.1016/j.nucmedbio.2013.02.010
  • 査読あり
• [雑誌論文] Kinetic analyses of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2. (2013)
  • 著者名/発表者名: Okudaira H, Nakanishi T, Oka S, Kobayashi M, Tamagami H, Schuster DM, Goodman MM, Shirakami Y, Tamai I, Kawai K.
  • 雑誌名: Nuclear Medicine and Biology 巻: 40 号: 5 ページ: 670-675
  • DOI: 10.1016/j.nucmedbio.2013.03.009
  • 査読あり
• [雑誌論文] The Usefulness of 18F-FDG PET/MRI Fusion Image in Diagnosing Pancreatic Tumor: Comparison with 18F-FDG PET/CT. (2013)
  • 著者名/発表者名: Nagamachi S., Nishii R., Wakamatsu H., Mizutani Y., Kiyohara S., Fujita S., Futami S., Sakae T., Furukoji E., Tamura S., Arita H., Chijiiwa K., Kawai K.
  • 雑誌名: Ann. Nucl. Med. 巻: 27(6) 号: 6 ページ: 554-563
  • DOI: 10.1007/s12149-013-0719-3
  • NAID: 10031189359
  • 査読あり
• [雑誌論文] Binding of Sulforhodamine B to Human Serum Albumin: A Spectroscopic Study. (2013)
  • 著者名/発表者名: Kitamura M., Murakami K., Yamada K., Kawai K., Kunishima M.
  • 雑誌名: Dyes and Pigments. 巻: 99(3) ページ: 588-593
  • 査読あり
• [雑誌論文] Diagnostic usefulness of an amino acid tracer, α-[N-methyl- ^11C]-methylaminoisobutyric acid ( ^<11>C-MeAIB), in the PET diagnosis of chest malignancies (2013)
  • 著者名/発表者名: Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M
  • 雑誌名: Ann Nucl Med 巻: 27(9) 号: 9 ページ: 808-21
  • DOI: 10.1007/s12149-013-0750-4
  • 査読あり
• [雑誌論文] Arterial 18F-Fluorodeoxyglucose Uptake Reflects Balloon Catheter-Induced Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions. (2013)
  • 著者名/発表者名: Yamashita A., Zhao Y., Zhao S., Matsuura Y., Sugita C., Iwakiri T., Okuyama N., Ohe K., Koshimoto C., Kawai K., Tamaki N., Kuge Y., Asada Y.
  • 雑誌名: Circ. J. 巻: 77(10) ページ: 2626-2635
  • 査読あり
• [雑誌論文] Comparative Evaluation of Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutane- carboxylic Acid and L-[Methyl-11C]methionine in Human Glioma Cell Lines. (2013)
  • 著者名/発表者名: Ono M., Oka S., Okudaira H., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.
  • 雑誌名: Brain Res. 巻: 1535 ページ: 24-37
  • DOI: 10.1016/j.brainres.2013.08.037
  • 査読あり
• [雑誌論文] Prototype Imaging Protocols for Monitoring the Efficacy of Iodine-131 Ablation in Differentiated Thyroid Cancer. (2013)
  • 著者名/発表者名: Kobayashi M., Wakabayashi H., Kojima H., Konishi T., Okuda K., Yoneyama H., Kayano D., Tobisaka M., Tsushima H., Onoguchi M., Kawai K., Kinuya S.
  • 雑誌名: Hell. J. Nucl. Med. 巻: 16(3) ページ: 175-180
  • 査読あり
• [雑誌論文] A diclofenac suppository-nabumetone combination therapy for arthritic pain relief and a monitoring method for the diclofenac binding capacity of HSA site II in rheumatoid arthritis (2013)
  • 著者名/発表者名: Nao Setoguchi, Norito Takamura, Ken-ichi Fujita, Kenji Ogata, Jin Tokunaga, Toyotaka Nishio, Etsuo Chosa, Kazuhiko Arimori, Keiichi Kawai, Ryuichi Yamamoto
  • 雑誌名: Biopharmaceutics & Drug Disposition 巻: 34 (2) 号: 2 ページ: 125-136
  • DOI: 10.1002/bdd.1829
  • 査読あり
• [雑誌論文] Pharmacokinetic Alteration of 99mTc-MAG3 using Serum Protein Binding Displacement Method. (2013)
  • 著者名/発表者名: K Nishi, M Kobayashi, R Nishii, N Shikano, N Takamura, N Kuga, K Yamasaki, S Nagamachi, S Tamura, M Otagiri, K Kawai.
  • 雑誌名: Nucl Med Biol 巻: 40 号: 3 ページ: 366-370
  • DOI: 10.1016/j.nucmedbio.2012.12.002
  • 査読あり
• [雑誌論文] N-Isopropyl-p-iodoamphetamine Hydrochloride (IMP) is Predominantly Metabolized by CYP2C19. (2012)
  • 著者名/発表者名: Fujita K., Sugiyama M., Akiyama Y., Hioki K., Kunishima M., Nishi K., Kobayashi M., Kawai K., Sasaki Y.
  • 雑誌名: Drug Metab. Dispos. 巻: 40 号: 5 ページ: 843-846
  • DOI: 10.1124/dmd.111.043893
  • 査読あり
• [雑誌論文] Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. (2012)
  • 著者名/発表者名: Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A, Namiki M, Kawai K, Tamai I.
  • 雑誌名: Biochem Pharmacol 巻: 84 号: 8 ページ: 1070-1077
  • DOI: 10.1016/j.bcp.2012.07.026
  • NAID: 120004997008
  • 査読あり
• [雑誌論文] Transport mechanism of (11)C-labeled L- and D-methionine in human-derived tumor cells. (2012)
  • 著者名/発表者名: M Kobayashi, F Hashimoto, K Ohe, T Nadamura, K Nishi, N Shikano, R Nishii, T Higashi, H Okazawa, K Kawai.
  • 雑誌名: Nucl Med Biol 巻: 39 号: 8 ページ: 1213-1218
  • DOI: 10.1016/j.nucmedbio.2012.06.006
  • 査読あり
• [雑誌論文] Down-regulation of Calcium/calmodulin-dependent Protein Kinase Kinase 2 by Androgen Deprivation Induces Castration-resistant Prostate Cancer. (2012)
  • 著者名/発表者名: Shima T., Mizokami A., Miyagi T., Kawai K., Izumi K., Kumaki M., Ofude M., Zhang J., Keller E.T., Namiki M.
  • 雑誌名: Prostate 巻: 72 号: 16 ページ: 1789-1801
  • DOI: 10.1002/pros.22533
  • 査読あり
• [学会発表] Transport Mechanism of the Amino Acid Positron Emission Tomography Tracer [18F]Fluciclovine and its Application to Glioma Diagnosis. (2014)
  • 著者名/発表者名: Ono M., Doi Y., Oka S., Okudaira H., Schuster D.M., Goodman M.M., Matsumoto H. Kawai K., Shirakami Y
  • 学会等名: 19th North American ISSX Meeting / 29th JSSX Meeting
  • 発表場所: Hilton San Francisco, San Francisco, California, U.S.A
  • 年月日: 2014-10-19
• [学会発表] Pharmacokinetics and Anti-tumor Activity of AY002 with High Affinity to EGFR-TK. (2014)
  • 著者名/発表者名: Yoshimoto M., Kimura S., Hirata M., Ohmomo Y., Kawai K., Fujii H.
  • 学会等名: The Society of Nuclear Medicine 61th Annual Meeting
  • 発表場所: Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
  • 年月日: 2014-06-07
• [学会発表] Radiosynthesis of [18F]FPYBF-2, a Novel PET Imaging Probe for β-Amyloid Plaques in Brain. (2014)
  • 著者名/発表者名: Kagawa S., Nishii R., Higashi T., Yamauchi H., Kawai K., Watanabe H., Kimura H., Ono M., Saji H.
  • 学会等名: The Society of Nuclear Medicine 61th Annual Meeting
  • 発表場所: Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
  • 年月日: 2014-06-07
• [学会発表] Introduction of Radiobromine Labeled Decalinvesamicol Analogue as a New and Promising PET Vesicular Acetylcholine Transporter (VAChT) Imaging Probe. (2014)
  • 著者名/発表者名: Azim M.A., Kosaka T., Uno I., Miwa D., Kitamura Y., Ogawa K., Kawai K., Kiyono Y., Shiba K.
  • 学会等名: The Society of Nuclear Medicine 61th Annual Meeting
  • 発表場所: Renaissance St. Louis Grand Hotel, St. Louis, Missouri, U.S.A.
  • 年月日: 2014-06-07
• [学会発表] Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage. (2014)
  • 著者名/発表者名: Yamashita A., Zhao Y., Matsuura Y., Yamasaki K., Moriguchi-Goto S., Iwakiri T., Okuyama N., Koshimoto C., Kawai K., Tamaki N., Zhao S., Kuge Y., Asada Y.
  • 学会等名: Arteriosclerosis, Thrombosis and Vascular Biology
  • 発表場所: Sheraton Centre Toronto Hotel, Toronto, Canada
  • 年月日: 2014-05-01
• [学会発表] 18F-FDG Uptake Reflects Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions. (2012)
  • 著者名/発表者名: Yamashita A., Zhao Y., Zhao S., Matsuura Y., Sugita C., Iwakiri T., Ohe K., Koshimoto C., Kawai K., Tamaki N., Kuge Y., Asada Y.
  • 学会等名: American Heart Association Scientific Sessions 2012
  • 発表場所: Los Angeles Convention Center (USA)
• [学会発表] Synthesis and Evaluation of Iodinated Cyclopropanecarboxylic Acid {3-[6-(Phenylamino)- pyrimidin-4-ylamino]-phenyl}-amides as EGFR-TK Imaging Agents.
  • 著者名/発表者名: Yoshimoto M., Kimura S., Yamada K., Hirata M., Ohmomo Y., Kunishima M., Kawai K., Fujii H.
  • 学会等名: 20th International Symposium on Radiopharmaceutical Sciences
  • 発表場所: Jeju International Convention Center (Korea)
• [学会発表] Radiosynthesis of [18F]Fluoroacetate by a One-pot Distillation Procedure: A Novel Approach of the Solid-phase Synthesis.
  • 著者名/発表者名: Kagawa S., Nishii R., Higashi T., Yamauchi H., Takemoto K., Hatano E., Tachibana A., Takahashi K., Mizuma H., Onoe H., Nagamachi S., Kawai K., Tamura S.
  • 学会等名: 20th International Symposium on Radiopharmaceutical Sciences
  • 発表場所: Jeju International Convention Center (Korea)
• [学会発表] Development of Novel EGFR-TK Imaging Agents based on Anilinopyrimidine Structure.
  • 著者名/発表者名: Yoshimoto M., Kimura S., Hirata M., Ohmomo Y., Kawai K., Fujii H.
  • 学会等名: The Society of Nuclear Medicine 60th Annual Meeting
  • 発表場所: Vancouver Convention Centre (Canada)
• [学会発表] Novel Approach for Solid-phase Radiosynthesis of 18F-Fluoroacetate: Comparison between One-pot and Two-pot Distillation Procedure.
  • 著者名/発表者名: Kagawa S., Nishii R., Higashi T., Yamauchi H., Takemoto K., Tachibana A., Takahashi K., Mizuma H., Onoe H., Kawai K.
  • 学会等名: The Society of Nuclear Medicine 60th Annual Meeting
  • 発表場所: Vancouver Convention Centre (Canada)
• [学会発表] The Development of Potential Vesicular Acetylcholine Transporter (VAChT) PET Imaging Probes.
  • 著者名/発表者名: Kosaka T., Miwa D., Uno I., Kitamura Y., Azim M.A., Ogawa K., Kinuya S., Kawai K., Shiba K.
  • 学会等名: The Society of Nuclear Medicine 60th Annual Meeting
  • 発表場所: Vancouver Convention Centre (Canada)
• [学会発表] In vivo Evaluation of Radioiodinated o-Iodo-trans-decalinvesamicol (OIDV) as a Vesicular Acetylcholine Transporter (VAChT ) Imaging Agent.
  • 著者名/発表者名: Uno I., Kosaka T., Kitamura Y., Miwa D., Azim M.A., Ogawa K., Kawai K., Taki J., Kinuya S., Shiba K.
  • 学会等名: The Society of Nuclear Medicine 60th Annual Meeting
  • 発表場所: Vancouver Convention Centre (Canada)
• [学会発表] Comparison between a High- and Medium-energy Collimator for Na131I Imaging of Differentiated Thyroid Cancer.
  • 著者名/発表者名: Kobayashi M., Wakabayashi H., Kayano D., Nishi K., Onoguchi M., Kawai K., Kinuya S.
  • 学会等名: The Society of Nuclear Medicine 60th Annual Meeting
  • 発表場所: Vancouver Convention Centre (Canada)
• [学会発表] Development of Ultra-high-resolution Pinhole Collimator for Small-animal SPECT with CZT Detector.
  • 著者名/発表者名: Nishi K., Kobayashi M., Matsunari I., Miyazaki Y., Shiba K., Kawai K., Kinuya S.
  • 学会等名: The Society of Nuclear Medicine 60th Annual Meeting
  • 発表場所: Vancouver Convention Centre (Canada)
• [学会発表] Transport Mechanism of Trans-1-amino-3-18F-fluorocyclobutanecarboxylic Acid (18F-FACBC) PET Radiotracer in Human Prostate Cancer.
  • 著者名/発表者名: Okudaira H., Oka S., Nakanishi T., Kobayashi M., Tamagami H., Schuster D.M., Goodman M.M., Shirakami Y., Tamai I., Kawai K.
  • 学会等名: The Society of Nuclear Medicine 60th Annual Meeting
  • 発表場所: Vancouver Convention Centre (Canada)
• [学会発表] System A Amino Acid Transport C-11 MeAIB PET/CT Imaging for Diagnosing Prostate Cancer.
  • 著者名/発表者名: Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Nagamachi S., Mizutani Y., Kawai K., Tamura S.
  • 学会等名: World Molecular Imaging Congress 2013
  • 発表場所: Savannah International Trade & Convention Centre (USA)
• [学会発表] Correlations between FDG Uptake Indices and the Expression of Various Type Oncogenes (KRAS, BRAF, HIF-1, EGFR, CDH13, p53, Ki67, Glut 1 and Glut 3) in Biliary Cancer: A Comparison Study to MRI Diffusion Weighted Image Parameters.
  • 著者名/発表者名: Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Shibata N., Kondo K., Kai M., Tamura S., Chijiiwa K., Kawai K., Fujita S., Wakamatsu H., Futami S.
  • 学会等名: Radiological Society of North America 2013, 99th Scientific Assembly and Annual Meeting
  • 発表場所: McCormick Place, Chicago (USA)
• [学会発表] The Correlation between SUVmax of 18F-FDG PET/CT and Apparent Diffusion Coefficients (ADC) in Pancreas Cancer and Biliary Cancer?
  • 著者名/発表者名: Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Furukoji E., Sakae T., Tamura S., Wakamatsu H., Fujita S., Futami S., Kawai K.
  • 学会等名: Radiological Society of North America 2013, 99th Scientific Assembly and Annual Meeting
  • 発表場所: McCormick Place, Chicago (USA)
• [学会発表] Evaluation of Radioiodinated PYK for Monitoring Active Mutation of EGFR-TK.
  • 著者名/発表者名: Yoshimoto M., Hirata M., Magata Y., Nishii R., Kawai K., Ohmomo Y.
  • 学会等名: The Society of Nuclear Medicine 59th Annual Meeting
  • 発表場所: Miami Beach Convention Center (USA)
• [学会発表] Accumulation Mechanism of 11C Labeled D-Methionine in Human-Derived Tumor Cells: Comparison with Gene Expression of Amino Acid Transporter System.
  • 著者名/発表者名: Kobayashi M., Hashimoto F., Ohe K., Nadamura T., Nishi K., Okudaira H., Higashi T., Shikano N., Nishii R., Kawai K.
  • 学会等名: The Society of Nuclear Medicine 59th Annual Meeting
  • 発表場所: Miami Beach Convention Center (USA)
• [学会発表] Assessment of Efficacy of [11C]MeAIB PET/CT as a Biomarker of the System A Amino Acid Transport: Comparison with [18F]FDG and MRI in the Patients with Prostate Cancer.
  • 著者名/発表者名: Higashi T., Nishii R., Kagawa S., Takahashi M., Kishibe Y., Yamauchi H., Ishitoya S., Oonishi H., Kawai K., Kobayashi M.
  • 学会等名: The Society of Nuclear Medicine 59th Annual Meeting
  • 発表場所: Miami Beach Convention Center (USA)
• [学会発表] Imaging Acquisition and Processing Protocols during Iodine-131 Therapy for Differentiated Thyroid Cancer.
  • 著者名/発表者名: Kobayashi M., Wakabayashi H., Kojima H., Konishi T., Okuda K., Kayano D., Tobisaka M., Onoguchi M., Kawai K., Kinuya S.
  • 学会等名: The Society of Nuclear Medicine 59th Annual Meeting
  • 発表場所: Miami Beach Convention Center (USA)
• [学会発表] Usefulness of System A Amino Acid Transport PET Imaging with C-11-MeAIB in Diagnosing Brain Tumors: A Comparison Study with C-11-Methionine PET Imaging.
  • 著者名/発表者名: Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Kobayashi M., Ohe K., Kawai K., Nagamachi S., Tamura S.
  • 学会等名: The Society of Nuclear Medicine 59th Annual Meeting
  • 発表場所: Miami Beach Convention Center (USA)
• [学会発表] Mechanism of Hepatic Uptake Transport and Bile Excretion in Hepatobiliary Scintigraphy with A 99mTc Labeled Pyridoxylaminate Group.
  • 著者名/発表者名: Kobayashi M., Ohe K., Nadamura T., Nishi K., Higashi T., Okudaira H., Shikano N., Nishii R., Kawai K.
  • 学会等名: The Society of Nuclear Medicine 59th Annual Meeting
  • 発表場所: Miami Beach Convention Center (USA)
• [学会発表] The Usefulness of 18F-PET/MRI Fusion Image in Diagnosing Pancreatic Tumor: Comparison with 18F-FDG PET/CT.
  • 著者名/発表者名: Nagamachi S., Nishii R., Mizutani Y., Kiyohara S., Wakamatsu H., Fujita S., Futami S., Tamura S., Kawai K.
  • 学会等名: The Society of Nuclear Medicine 59th Annual Meeting
  • 発表場所: Miami Beach Convention Center (USA)
• [学会発表] 薬物動態解析に特化した小動物用インビボ分子イメージング装置の開発
  • 著者名/発表者名: 川井恵一
  • 学会等名: 石川県産業創出支援機構 平成24年度医療機器開発マッチングフォーラム
  • 発表場所: 金沢大学 （石川県）
  • 招待講演
• [図書] 「放射線関係法規概説 －医療分野も含めて－」（第５版） (2013)
  • 著者名/発表者名: 川井恵一
  • 総ページ数: 222
  • 出版者: 通商産業研究社
• [備考] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html
• [備考] 金沢大学 研究者情報
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=
• [備考] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html
• [備考] 金沢大学 研究紹介
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=
• [備考] 金沢大学 研究紹介データベース
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2789&page=1&search=1&keyword=%E5%B7%9D%E4%BA%95%E3%80%80%E6%83%A0%E4%B8%80&andor=AND&tgt1=1&tgt2=&tgt3=&tgt4=
• [備考] 金沢大学医薬保健研究域保健学系 量子医療技術学講座 川井研究室
  • URL: http://kawai.w3.kanazawa-u.ac.jp/index.html