がん幹細胞のＧｅｎｅｔｉｃ ｉｎｓｔａｂｉｌｉｔｙに着目した新しい癌治療の構築

• 研究課題/領域番号: 24659614
• 研究種目: 挑戦的萌芽研究
• 配分区分: 補助金
• 研究分野: 消化器外科学
• 研究機関: 九州大学
• 研究代表者: 前原 喜彦 九州大学, 医学(系)研究科(研究院), 教授 (80165662)
• 研究期間 (年度): 2012-04-01 – 2014-03-31
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 3,770千円 (直接経費: 2,900千円、間接経費: 870千円); 2013年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円); 2012年度: 2,210千円 (直接経費: 1,700千円、間接経費: 510千円)
• キーワード: 染色体不安定性 / 酸化ストレス / BuBR1 / p53 / がん幹細胞 / LgR5 / LGR5 / 遺伝子不安定性 / 癌幹細胞 / CD44

研究概要

がん幹細胞は化学療法や放射線などの治療へ抵抗性を示すために残存しやすく、がん幹細胞を標的とした治療法を確立することで再発、転移のリスクが少ない新しいがん治療が構築できるものと期待されている。私達は、癌が部分的に低酸素や化学刺激に暴露されている状況で、一部の細胞が幹細胞化するとともに遺伝子の不安定性を生じやすくなっており、これが治療抵抗性を生じさせている原因の一つと考えている。細胞株を用いた検討で、酸化ストレスで染色体不安定性が生じる原因を検討するとともに、臨床検体を用いて、実際の癌で治療後に幹細胞化や遺伝子不安定性が生じているのかを検討した。

研究成果

• [雑誌論文] Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy (2014)
  • 著者名/発表者名: Umemoto Y, Okano S, Matsumoto Y, Nakagawara H, Matono R, Yoshiya S, Yamashita YI, Yoshizumi T, Ikegami T, Soejima Y, Harada M, Aishima S, Oda Y, Shirabe K, Maehara Y
  • 雑誌名: J Gastroenterol
• [雑誌論文] A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP), for assessing liver fibrosis (2014)
  • 著者名/発表者名: Toshima T, Shirabe K, Ikegami T, Yoshizumi T, Kuno A, Togayachi A, Gotoh M, Narimatsu H, Korenaga M, Mizokami M, Nishie A, Aishima S, Maehara Y
  • 雑誌名: J Gastroenterol
• [雑誌論文] Allelic Imbalance at an 8q24 Oncogenic SNP is Involved in Activating MYC in Human Colorectal Cancer (2014)
  • 著者名/発表者名: Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K
  • 雑誌名: Ann Surg Oncol
• [雑誌論文] Phase II Study of Docetaxel and S-1 (DS) as Neoadjuvant Chemotherapy for Clinical Stage III Resectable Gastric Cancer (2014)
  • 著者名/発表者名: Oki E, Emi Y, Kusumoto T, Sakaguchi Y, Yamamoto M, Sadanaga N, Shimokawa M, Yamanaka T, Saeki H, Morita M, Takahashi I, Hirabayashi N, Sakai K, Orita H, Aishima S, Kakeji Y, Yamaguchi K, Yoshida K, Baba H, Maehara Y
  • 雑誌名: Ann Surg Oncol
• [雑誌論文] Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus (2014)
  • 著者名/発表者名: Nakanoko T, Saeki H, Morita M, Nakashima Y, Ando K, Oki E, Ohga T, Kakeji Y, Toh Y, Maehara Y
  • 雑誌名: Ann Surg Oncol 巻: 21 ページ: 597-604
• [雑誌論文] Balloon-occluded retrograde transvenous obliteration is feasible for prolonged portosystemic shunts after living donor liver transplantation (2014)
  • 著者名/発表者名: Nagao Y, Akahoshi T, Uehara H, Hashimoto N, Kinjo N, Kawanaka H, Tomikawa M, Uchiyama H, Yoshizumi T, Soejima Y, Shirabe K, Maehara Y
  • 雑誌名: Surg Today 巻: 44 ページ: 633-639
• [雑誌論文] Technical improvement of total pharyngo-laryngo-esophagectomy for esophageal cancer and head and neck cancer (2014)
  • 著者名/発表者名: Morita M, Saeki H, Ito S, Ikeda K, Yamashita N, Ando K, Hiyoshi Y, Ida S, Tokunaga E, Uchiyama H, Oki E, Ikeda T, Yoshida S, Nakashima T, Maehara Y
  • 雑誌名: Ann Surg Oncol 巻: 21 ページ: 1671-1677
• [雑誌論文] Gender differences in prognosis after esophagectomy for esophageal cancer (2014)
  • 著者名/発表者名: Morita M, Otsu H, Kawano H, Kasagi Y, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Tokunaga E, Ikeda T, Kusumoto T, Maehara Y
  • 雑誌名: Surg Today 巻: 44 ページ: 505-512
• [雑誌論文] Prognostic and Therapeutic Implications of Aromatase Expression in Lung Adenocarcinomas with EGFR mutations (2014)
  • 著者名/発表者名: Kohno M, Okamoto T, Suda K, Shimokawa M, Kitahara H, Shimamatsu S, Konishi H, Yoshida T, Takenoyama M, Yano T, Maehara Y
  • 雑誌名: Clin Cancer Res
• [雑誌論文] Significance of preoperative evaluation of the right gastroepiploic artery graft to the coronary artery in patients undergoing abdominal surgery (2014)
  • 著者名/発表者名: Ito S, Yamaguchi S, Saeki H, Oki E, Tayama E, Ikejiri K, Morita M, Maehara Y
  • 雑誌名: World JSurg 巻: 38 ページ: 1051-1057
• [雑誌論文] Splenic volume may be a useful indicator of the protective effect of bevacizumab against oxaliplatin-induced hepatic sinusoidal ostruction syndrome (2014)
  • 著者名/発表者名: Imai K, Emi Y, Iyama KI, Beppu T, Ogata Y, Kakeji Y, Samura H, Oki E, Akagi Y, Maehara Y, Baba H
  • 雑誌名: Ear JSurg Oncol 巻: 40 ページ: 559-566
• [雑誌論文] A high MELD score, combined with the presence of hepatitis C, is associated with a poor prognosis in living donor liver transplantation (2014)
  • 著者名/発表者名: Ikegami T, Shirabe K, Yoshiya S, Yoshizumi T, Yamashita Y, Harimoto N, Toshima T, Uchiyama H, Soejima Y, Maehara Y
  • 雑誌名: Surg Today 巻: 44 ページ: 233-240
• [雑誌論文] Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer (2014)
  • 著者名/発表者名: Ida S, Morita M, Hiyoshi Y, Ikeda K, Ando K, Kimura Y, Saeki H, Oki E, Kusumoto T, Yoshida S, Nakashima T, Watanabe M, Baba H, Maehara Y
  • 雑誌名: Ann Surg Oncol 巻: 21 ページ: 1175-1181
• [雑誌論文] Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers (2014)
  • 著者名/発表者名: Honma K, Nakanishi R, Nakanoko T, Ando K, Saeki H, Oki E, Iimori M, Kitao H, Kakeji Y, Maehara Y
  • 雑誌名: Surg Today 巻: 44 ページ: 454-461
• [雑誌論文] Impact of GATA-3 and FOXA1 expression in patients with hormone receptor-positive/HER2-negative breast cancer (2014)
  • 著者名/発表者名: Hisamatsu Y, Tokunaga E, Yamashita N, Akiyoshi S, Okada S, Nakashima Y, Taketani K, Aishima S, Oda Y, Morita M, Maehara Y
  • 雑誌名: Breast Cancer
• [雑誌論文] Mortalin is a prognostic factor of gastric cancer with normal p53 function (2014)
  • 著者名/発表者名: Ando K, Oki E, Zhao Y, Ikawa-Yoshida A, Kitao H, Saeki H, Kimura Y, Ida S, Morita M, Kusumoto T, Maehara Y
  • 雑誌名: Gastric Cancer 巻: 17 ページ: 255-262
• [雑誌論文] Mortalin is a prognostic factor of gastric cancer with normal p53 function. (2014)
  • 著者名/発表者名: Ando K., Oki E., Zhao Y., Yoshida A., Kitao H., Saeki H., Kimura Y., Ida S., Morita M., Kusumoto T., Maehara Y.
  • 雑誌名: Gastric Cancer 巻: 17(2) 号: 2 ページ: 255-262
  • DOI: 10.1007/s10120-013-0279-1
  • 査読あり / オープンアクセス
• [雑誌論文] Rendezvous ductoplasty for biliary anastomotic stricture after living-donor liver transplantation (2013)
  • 著者名/発表者名: Yoshiya S, Shirabe K, Matsumoto Y, Ikeda T, Soejima Y, Yoshizumi T, Uchiyama H, Ikegami T, Harimoto N, Maehara Y
  • 雑誌名: Transplantation 巻: 95 ページ: 1278-1283
• [雑誌論文] DVC1-0101 to treat peripheral arterial disease : a Phase I/IIa open-label dose-escalation clinical trial (2013)
  • 著者名/発表者名: Yonemitsu Y, Matsumoto T, Itoh H, Okazaki J, Uchiyama M, Yoshida K, Onimaru M, Onohara T, Inoguchi H, Kyuragi R, Shimokawa M, Ban H, Tanaka M, Inoue M, Shu T, Hasegawa M, Nakanishi Y, Maehara Y
  • 雑誌名: Mol Ther 巻: 21 ページ: 707-714
• [雑誌論文] Surgical outcomes of pancreaticoduodenectomy for periampullary tumors in elderly patients (2013)
  • 著者名/発表者名: Yamashita Y, Shirabe K, Tsujita E, Takeishi K, Ikeda T, Yoshizumi T, Furukawa Y, Ishida T, Maehara Y
  • 雑誌名: Langenbecks Arch Surg 巻: 398 ページ: 539-545
• [雑誌論文] Third or more repeat hepatectomy for recurrent hepatocellular carcinoma (2013)
  • 著者名/発表者名: Yamashita Y, Shirabe K, Tsuijita E, Takeishi K, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Utsunomiya T, Maehara Y
  • 雑誌名: Surgery 巻: 154 ページ: 1038-1045
• [雑誌論文] Risk factors for recurrence after curative resection of hepatitis C-related hepatocellular carcinoma in patients without postoperative interferon therapy (2013)
  • 著者名/発表者名: Yamashita Y, Shirabe K, Toshima T, Tsuijita E, Takeishi K, Harimoto N, Ikegami T, Yoshizumi T, Ikeda T, Soejima Y, Maehara Y
  • 雑誌名: Hepatol Res 巻: 43 ページ: 1313-1320
• [雑誌論文] Vimentin as a poor prognostic factor for triple-negative breast cancer (2013)
  • 著者名/発表者名: Yamashita N, Tokunaga E, Kitao H, Hisamatsu Y, Taketani K, Akiyoshi S, Okada S, Aishima S, Morita M, Maehara Y
  • 雑誌名: J Cancer Res Clin Oncol 巻: 139 ページ: 739-746
• [雑誌論文] Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance (2013)
  • 著者名/発表者名: Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, Oki E, Morita M, Maehara Y
  • 雑誌名: PLoS One 巻: 8
• [雑誌論文] Image-guided laparoscopic surgery in an open MRI operating theater (2013)
  • 著者名/発表者名: Tsutsumi N, Tomikawa M, Uemura M, Akahoshi T, Nagao Y, Konishi K, Ieiri S, Hong J, Maehara Y, Hashizume M
  • 雑誌名: Surg Endosc 巻: 27 ページ: 2178-2184
• [雑誌論文] Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer (2013)
  • 著者名/発表者名: Takeshita M, Koga T, Takayama K, Ijichi K, Yano T, Maehara Y, Nakanishi Y, Sueishi K
  • 雑誌名: Lung Cancer 巻: 80 ページ: 85-90
• [雑誌論文] Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells (2013)
  • 著者名/発表者名: Sugimachi K, Yokobori T, Iinuma H, Ueda M, Ueo H, Shinden Y, Eguchi H, udo T, Suzuki A, Maehara Y, Mori M,Mimori K
  • 雑誌名: Ann Surg Oncol
• [雑誌論文] Multimodal treatment strategy for clinical T3 thoracic esophageal cancer (2013)
  • 著者名/発表者名: Saeki H, Morita M, Tsuda Y, Hidaka G, Kasagi Y, Kawano H, Otsu H, Ando K, Kimura Y, Oki E, Kusumoto T, Maehara Y
  • 雑誌名: Ann Surg Oncol 巻: 20 ページ: 4267-4273
• [雑誌論文] Impact of second-line and later cetuximab-containing therapy and KRAS genotypes in patients with metastatic colorectal cancer : a multicenter study in Japan (2013)
  • 著者名/発表者名: Saeki H, Emi Y, Kumashiro R, Otsu H, Kawano H, Ando K, Ida S, Kimura Y, Tokunaga E, Oki E, Morita M, Shimokawa M, Maehara Y
  • 雑誌名: Surg Today
• [雑誌論文] Phase II trial of alternating mFOLFOX6 and FOLFIRI regimens in the first-line treatment for unresectable or metastatic colorectal cancer (KSCC0701) (2013)
  • 著者名/発表者名: Oki E, Emi Y, Akagi Y, Tokunaga S, Sadanaga N, Tanaka T, Ogata Y, Saeki H, Kakeji Y, Baba H, Nishimaki T, Natsugoe S, Shirouzu K, Maehara Y
  • 雑誌名: Oncology 巻: 84 ページ: 233-239
• [雑誌論文] Dedifferentiated liposarcoma of the spermatic cord with a hemangioendothelioma-like component : a case report and review of the literature (2013)
  • 著者名/発表者名: Okano S, Yamamoto H, Kono S, Fujii H, Shirabe K, Maehara Y, Oda Y
  • 雑誌名: Pathol Res Pract 巻: 209 ページ: 596-604
• [雑誌論文] CD4 T cell-mediated masking effects of the immunogenicity of tumor-associated antigens are qualitatively and quantitatively different depending on the individual antigens (2013)
  • 著者名/発表者名: Okano S, Matsumoto Y, Yoshiya S, Yamashita Y, Harimoto N, Ikegami T, Shirabe K, Harada M, Yoshikai Y, Maehara Y
  • 雑誌名: Fukuoka Igaku Zasshi 巻: 104 ページ: 1-14
  • NAID: 120005227183
• [雑誌論文] Fas-deficient fully allogeneic dendritic cells administered via an intratumoral injection route show efficient antitumor effects in murine models (2013)
  • 著者名/発表者名: Okano S, Kondoh H, Toshima T, Nakagawara H, Yoshizumi T, Soejima Y. Shirabe K, Harada M, Yoshikai Y, Maehara Y
  • 雑誌名: Fukuoka Igaku Zasshi 巻: 104 ページ: 15-26
  • NAID: 120005227184
• [雑誌論文] Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion (2013)
  • 著者名/発表者名: Nakashima Y, Yoshinaga K, Kitao H, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Kakeji Y, Hirahashi M, Oda Y, Maehara Y
  • 雑誌名: Cancer Sci 巻: 104 ページ: 1718-1725
• [雑誌論文] Advances in esophageal surgery in elderly patients with thoracic esophageal cancer (2013)
  • 著者名/発表者名: Morita M, Otsu H, Kawano H, Kumashiro R, Taketani K, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Tokunaga E, Ikeda T, Kusumoto T, Maehara Y
  • 雑誌名: Anticancer Res 巻: 33 ページ: 1641-1647
• [雑誌論文] Surgical resection for esophageal cancer synchronously or metachronously associated with head and neck cancer (2013)
  • 著者名/発表者名: Morita M, Kawano H, Otsu H, Kimura Y, aeki H, Ando K, Ida S, Oki E, Ikeda T, Kusumoto T, Fukushima J, Nakashima T, Maehara Y
  • 雑誌名: Ann Surg Oncol 巻: 20 ページ: 2434-2439
• [雑誌論文] Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma (2013)
  • 著者名/発表者名: Mano Y, Aishima S, Fukuhara T, Tanaka Y, Kubo Y, Motomura T, Toshima T, Iguchi T, Shirabe K, Maehara Y, Oda Y
  • 雑誌名: Hum Pathol 巻: 44 ページ: 2419-2426
• [雑誌論文] Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma (2013)
  • 著者名/発表者名: Mano Y, Aishima S, Fujita N, Tanaka Y, Kubo Y, Motomura T, Taketomi A, Shirabe K, Maehara Y, Oda Y
  • 雑誌名: Pathobiology 巻: 80 ページ: 146-154
• [雑誌論文] Endovascular aneurysm repair for an abdominal aortic aneurysm and a left ruptured common iliac artery aneurysm in a patient with hepatocellular carcinoma : report of a case (2013)
  • 著者名/発表者名: Kyuragi R, Matsumoto T, Okadome J, Kawakubo E, Homma K, Iwasa K, Guntani A, Okazaki J, Maehara Y
  • 雑誌名: Surg Today
• [雑誌論文] Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C (2013)
  • 著者名/発表者名: Konishi H, Shirabe K, Yoshiya S, Ikeda T, Ikegami T, Yoshizumi T, Ikawa-Yoshida A, Motomura T, Fukuhara T, Maehara Y
  • 雑誌名: Hepatol Res 巻: 43 ページ: 1139-1147
• [雑誌論文] Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients (2013)
  • 著者名/発表者名: Kinjo N, Nagao Y, Akahoshi T, Masahiro K, Hashimoto N, Uehara H, Kawanaka H, Tomikawa M, Shirabe K, Hashizume M, Maehara Y
  • 雑誌名: Hepatol Res 巻: 43 ページ: 933-941
• [雑誌論文] Liver regeneration and venous collateral formation in the right lobe living-donor remnant : segmental volumetric analysis and three-dimensional visualization (2013)
  • 著者名/発表者名: Kayashima H, Shirabe K, Morita K, Hashimoto N, Ikegami T, Yoshizumi T, Soejima Y, Maehara Y
  • 雑誌名: Transplantation 巻: 95 ページ: 353-360
• [雑誌論文] Use of the SAND balloon catheter in single-incision laparoscopic cholecystectomy for acute cholecystitis (2013)
  • 著者名/発表者名: Ikegami T, Shirabe K, Yoshizumi T, Kayashima H, Maehara Y
  • 雑誌名: Asian JEndosc Surg 巻: 6 ページ: 134-136
• [雑誌論文] Obstructing spontaneous major shunt vessels is mandatory to keep adequate portal inflow in living-donor liver transplantation (2013)
  • 著者名/発表者名: Ikegami T, Shirabe K, Nakagawara H, Yoshizumi T, Toshima T, Soejima Y, Uchiyama H, Yamashita Y, Harimoto N, Maehara Y
  • 雑誌名: Transplantation 巻: 95 ページ: 1270-1277
• [雑誌論文] Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells (2013)
  • 著者名/発表者名: Ikawa-Yoshida A, Ando K, Oki E, Saeki H, Kumashiro R, Taketani K, Ida S, Tokunaga E, Kitao H, Morita M, Maehara Y
  • 雑誌名: Cancer Med 巻: 2 ページ: 447-456
• [雑誌論文] Expression of Brachyury gene is a significant prognostic factor for primary lung carcinoma (2013)
  • 著者名/発表者名: Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T, Takenoyama M, Maehara Y
  • 雑誌名: Ann Surg Oncol 巻: 20 Suppl 3
• [雑誌論文] Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma (2013)
  • 著者名/発表者名: Harimoto N, Shirabe K, Yamashita YI, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Maehara Y, Nishie A, Yamanaka T
  • 雑誌名: Br JSurg 巻: 100 ページ: 1523-1530
• [雑誌論文] Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells. (2013)
  • 著者名/発表者名: Ikawa-Yoshida A., Ando K., Oki E., Saeki H., Kumashiro R., Taketani K., Ida S., Tokunaga E., Kitao H., Morita M., Maehara Y.
  • 雑誌名: Cancer Medicine 巻: 2(4) 号: 4 ページ: 447-456
  • DOI: 10.1002/cam4.101
  • 査読あり
• [雑誌論文] Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion. (2013)
  • 著者名/発表者名: Nakashima Y, Yoshinaga K, Kitao H, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Kakeji Y, Hirahashi M, Oda Y, Maehara Y
  • 雑誌名: Cancer Sci 巻: 104 号: 12 ページ: 1718-1725
  • DOI: 10.1111/cas.12286
  • 査読あり
• [雑誌論文] Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer (2013)
  • 著者名/発表者名: Nakanishi R
  • 雑誌名: Int J Clin Oncol 巻: Nov 29
  • 査読あり
• [雑誌論文] Vimentin as a poor prognostic factor for triple-negative breast cancer. (2013)
  • 著者名/発表者名: Yamashita N
  • 雑誌名: J Cancer Res Clin Oncol 巻: Jan 26
  • 査読あり
• [雑誌論文] Technical evolution of laparoscopic hepatic resection : a single institutional experience (2012)
  • 著者名/発表者名: Soejima Y, Ikegami T, Ijichi H, Ikeda T, Shirabe K, Yoshizumi T, Uchiyama H, Yamashita Y, Harimoto N, Toshima T, Matsuura H, Okadome K, Maehara Y
  • 雑誌名: Fukuoka Igaku Zasshi 巻: 103 ページ: 226-232
  • NAID: 120005068814
• [雑誌論文] Surgical management of hepatocellular carcinoma in Child-Pugh class B cirrhotic patients : hepatic resection and/or microwave coagulation therapy versus living donor liver transplantation (2012)
  • 著者名/発表者名: Harada N, Shirabe K, Ikeda Y, Korenaga D, Takenaka K, Maehara Y
  • 雑誌名: Ann Transplant 巻: 17 ページ: 11-20
• [雑誌論文] CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication (2012)
  • 著者名/発表者名: Sakasai R
  • 雑誌名: Genes Cells 巻: 17 ページ: 962-970
  • 査読あり
• [雑誌論文] FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer (2012)
  • 著者名/発表者名: Nakanishi R
  • 雑誌名: Ann Surg Oncol 巻: 19 ページ: 3627-3635
  • 査読あり
• [雑誌論文] Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers. (2012)
  • 著者名/発表者名: Oki E
  • 雑誌名: J Gastroenterol 巻: 47 ページ: 351-358
  • 査読あり
• [学会発表] 胃癌における細胞周期の制御因子Plk1過剰発現と染色体不安定性の関連 (2012)
  • 著者名/発表者名: 大津 甫他
  • 学会等名: 日本消化器外科学会総会
  • 発表場所: 富山
• [学会発表] 胃癌における紡錘体形成チェックポイントタンパク質BUBR1発現およびDNA aneuploidyの意義 (2012)
  • 著者名/発表者名: 安藤幸滋他
  • 学会等名: 日本外科学会定期学術集会
  • 発表場所: 千葉