肝癌幹細胞におけるｍｉＲＮＡの解析：発癌予防と抑制そして転移制圧に向けて

• 研究課題/領域番号: 24890081
• 研究種目: 研究活動スタート支援
• 配分区分: 補助金
• 研究分野: 消化器内科学
• 研究機関: 岐阜大学
• 研究代表者: 末次 淳 岐阜大学, 医学部附属病院, 助教 (30340079)
• 研究期間 (年度): 2012-08-31 – 2014-03-31
• 研究課題ステータス: 完了 (2013年度)
• 配分額: 2,990千円 (直接経費: 2,300千円、間接経費: 690千円); 2013年度: 1,430千円 (直接経費: 1,100千円、間接経費: 330千円); 2012年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
• キーワード: 肝癌 / 癌幹細胞 / miRNA

研究概要

癌は,原発巣及び転移巣において微小環境を形成し、その癌組織内は癌細胞のみでなく、周囲の癌関連細胞が重要な役割を果たしている。原発巣及び肝転移において、癌細胞周囲の癌関連繊維芽細胞や腫瘍関連マクロフャージの重要性が明らかにされた。癌細胞内のエクソソームが転移前に繊維芽細胞内に入り込み、転移する環境を形成することを視覚的に証明した。さらに、血液などの体液中に分泌され、他の細胞に取り込まれることを確かめられ、エクソソームを介した細胞間コミュニケーションが存在することを示唆していた。癌形成及び転移時において,癌細胞と周囲の細胞間のコミュニケーションは必要であることが証明された。

研究成果

• [雑誌論文] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis : chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids (2014)
  • 著者名/発表者名: Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H
  • 雑誌名: Mol Nutr Food Res. 巻: 58(1) ページ: 124-35
• [雑誌論文] Free fatty acid as a marker of energy malnutrition in liver cirrhosis (2014)
  • 著者名/発表者名: Hanai T, Shiraki M, Nishimura K, Imai K, Suetsugu A, Takai K, Shimizu M, Naiki T, Moriwaki H
  • 雑誌名: Hepatol Res. 巻: 44(2) ページ: 218-28
• [雑誌論文] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids. (2014)
  • 著者名/発表者名: Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H.
  • 雑誌名: Mol Nutr Food Res. 巻: 58 号: 1 ページ: 124-135
  • DOI: 10.1002/mnfr.201300538
  • 査読あり
• [雑誌論文] Efficacy of Salmonella typhimurium A1-R Versus Chemotherapy on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX). (2014)
  • 著者名/発表者名: Hiroshima Y, Zhao M, Maawy A, Zhang Y, Katz MH, Fleming JB, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
  • 雑誌名: J Cell Biochem 巻: 115(7) 号: 7 ページ: 1254-61
  • DOI: 10.1002/jcb.24769
  • 査読あり
• [雑誌論文] Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level (2013)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM
  • 雑誌名: J Cell Biochem. 巻: 114(2) ページ: 428-34
• [雑誌論文] Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude mouse models (2013)
  • 著者名/発表者名: Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM
  • 雑誌名: Adv Drug Deliv Rev. 巻: 65(3) ページ: 383-90
• [雑誌論文] Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice (2013)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 33(1) ページ: 103-6
• [雑誌論文] Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice (2013)
  • 著者名/発表者名: Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Yano S, Bouvet M, Chishima T, Endo I, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 33(1) ページ: 107-11
• [雑誌論文] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer (2013)
  • 著者名/発表者名: Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O
  • 雑誌名: J Clin Invest. 巻: 123(2) ページ: 834-43
• [雑誌論文] Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice (2013)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 33(4) ページ: 1367-71
• [雑誌論文] In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells (2013)
  • 著者名/発表者名: Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM
  • 雑誌名: PLoS One 巻: 8(7)
• [雑誌論文] Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells (2013)
  • 著者名/発表者名: Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM
  • 雑誌名: Cell Cycle 巻: 12(17) ページ: 2774-80
• [雑誌論文] Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling (2013)
  • 著者名/発表者名: He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M
  • 雑誌名: Cell 巻: 155(2) ページ: 384-96
• [雑誌論文] Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice (2013)
  • 著者名/発表者名: Suetsugu A, Jiang P, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 33(10) ページ: 4229-36
• [雑誌論文] Development of a clinically-precise mouse model of rectal cancer (2013)
  • 著者名/発表者名: Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM
  • 雑誌名: PLoS One 巻: 8(11)
• [雑誌論文] Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level. (2013)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM.
  • 雑誌名: J Cell Biochem 巻: 114 (2) 号: 2 ページ: 428-34
  • DOI: 10.1002/jcb.24381
  • 査読あり
• [雑誌論文] Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude mouse models. (2013)
  • 著者名/発表者名: Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM.
  • 雑誌名: Adv Drug Deliv Rev. 巻: 65 号: 3 ページ: 383-390
  • DOI: 10.1016/j.addr.2012.08.007
  • 査読あり
• [雑誌論文] Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. (2013)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM.
  • 雑誌名: Anticancer Res. 巻: 33 ページ: 103-106
  • 査読あり
• [雑誌論文] Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice. (2013)
  • 著者名/発表者名: Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Yano S, Bouvet M, Chishima T, Endo I, Hoffman RM.
  • 雑誌名: Anticancer Res. 巻: 33 ページ: 107-111
  • 査読あり
• [雑誌論文] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer． (2013)
  • 著者名/発表者名: Osawa Y,Saibara T et.al
  • 雑誌名: Journal Clin Invest 巻: 123(2) ページ: 834-843
  • DOI: 10.1172/jci65188
  • 査読あり
• [雑誌論文] Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice. (2013)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM.
  • 雑誌名: Anticancer Res. 巻: 33 ページ: 1367-1371
  • 査読あり
• [雑誌論文] Free fatty acid as a marker of energy malnutrition in liver cirrhosis. (2013)
  • 著者名/発表者名: Hanai T, Shiraki M, Nishimura K, Imai K, Suetsugu A, Takai K, Shimizu M, Naiki T, Moriwaki H.
  • 雑誌名: Hepatol Res. 巻: 44 号: 2 ページ: 218-228
  • DOI: 10.1111/hepr.12112
  • 査読あり
• [雑誌論文] In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. (2013)
  • 著者名/発表者名: Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM.
  • 雑誌名: PLoS One. 巻: 8 号: 7 ページ: e69658-e69658
  • DOI: 10.1371/journal.pone.0069658
  • 査読あり
• [雑誌論文] Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells. (2013)
  • 著者名/発表者名: Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
  • 雑誌名: Cell Cycle 巻: 1;12(17) 号: 17 ページ: 2774-80
  • DOI: 10.4161/cc.25872
  • 査読あり
• [雑誌論文] Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. (2013)
  • 著者名/発表者名: He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M.
  • 雑誌名: Cell. 巻: 155 号: 2 ページ: 384-396
  • DOI: 10.1016/j.cell.2013.09.031
  • 査読あり
• [雑誌論文] Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice. (2013)
  • 著者名/発表者名: Suetsugu A, Jiang P, Moriwaki H, Saji S, Bouvet M, Hoffman RM.
  • 雑誌名: Anticancer Res. 巻: 33 ページ: 4229-4236
  • 査読あり
• [雑誌論文] Development of a clinically-precise mouse model of rectal cancer. (2013)
  • 著者名/発表者名: Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM
  • 雑誌名: PLoS One 巻: 8 号: 11 ページ: e79453-e79453
  • DOI: 10.1371/journal.pone.0079453
  • 査読あり
• [雑誌論文] Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. (2013)
  • 著者名/発表者名: 13. Momiyama M
  • 雑誌名: Anticancer Res 巻: 33 ページ: 103-106
  • 査読あり
• [雑誌論文] Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice. (2013)
  • 著者名/発表者名: 15. Momiyama M
  • 雑誌名: Anticancer Res 巻: 33 ページ: 107-111
  • 査読あり
• [雑誌論文] Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice (2012)
  • 著者名/発表者名: Zhao M, Suetsugu A, Ma H, Zhang L, Liu F, Zhang Y, Tran B, Hoffman RM
  • 雑誌名: Cell Cycle 巻: 1 ページ: 187-93
• [雑誌論文] The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments (2012)
  • 著者名/発表者名: Suetsugu A, Hassanein MK, Reynoso J, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 1 ページ: 31-8
• [雑誌論文] Imageable Metastasis Occuring in Transgenic GFP Mice Orthotopically Implanted with Human-Patient Primary Pancreatic Cancer Specimens (2012)
  • 著者名/発表者名: Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 4 ページ: 1175-80
• [雑誌論文] Major liver resection stimulates atromal recruitment and metastasis compared with repeated minor resection (2012)
  • 著者名/発表者名: Momiyama M, Kumamoto T, Suetsugu A, Kishimoto H, Chishima T, Tanaka K, Akiyama H, Ichikawa Y, Bouvet M, Endo I, Hoffman RM
  • 雑誌名: J Surg Res. 巻: 178(1) ページ: 280-7
• [雑誌論文] Multi-color pallet of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens (2012)
  • 著者名/発表者名: Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • 雑誌名: J Cell Biochem. 巻: 7 ページ: 2290-5
• [雑誌論文] Inhibition of metastasis of circulating human prostate cancer cells in the chick embryo by an extracellular matrix produced by foreskin fibroblasts in culture (2012)
  • 著者名/発表者名: Menen R, Pinney E, Hassanein MK, Kolostova K, Bobek V, Suetsugu A, Zhang N, Bouvet M, Naughton GK, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 5 ページ: 1573-7
• [雑誌論文] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice (2012)
  • 著者名/発表者名: Zhang Y, Tome Y, Suetsugu A, Zhang L, Zhang N, Hoffman RM, Zhao M
  • 雑誌名: Anticancer Res. 巻: 7 ページ: 2501-8
• [雑誌論文] Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu (2012)
  • 著者名/発表者名: Hu M, Zhao M, An C, Yang M, Li Q, Zhang Y, Suetsugu A, Tome Y, Yano S, Fu Y, Hoffman RM, Hu K
  • 雑誌名: Anticancer Res. 巻: 7 ページ: 2509-14
• [雑誌論文] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer (2012)
  • 著者名/発表者名: Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Moossa AR, Hoffman RM, Bouvet M
  • 雑誌名: In Vivo. 巻: 26(4) ページ: 565-9
• [雑誌論文] Non-invasive Fluorescent-protein Imaging of Orthotopic Pancreatic-cancer-patient Tumorgraft Progression in Nude Mice (2012)
  • 著者名/発表者名: Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 8 ページ: 3063-7
• [雑誌論文] Fluorescent proteins enhance UVC PDT of cancer cells (2012)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Bulgakova NN, Endo I, Hoffman RM
  • 雑誌名: Anticancer Res. 巻: 10
• [雑誌論文] Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice. (2012)
  • 著者名/発表者名: Zhao M
  • 雑誌名: Cell Cycle 巻: 1 号: 1 ページ: 187-193
  • DOI: 10.4161/cc.11.1.18667
  • 査読あり
• [雑誌論文] The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments. (2012)
  • 著者名/発表者名: Suetsugu A
  • 雑誌名: Anticancer Res 巻: 1 ページ: 31-38
  • 査読あり
• [雑誌論文] Imageable Metastasis Occuring in Transgenic GFP Mice Orthotopically Implanted with Human-Patient Primary Pancreatic Cancer Specimens. (2012)
  • 著者名/発表者名: Suetsugu A
  • 雑誌名: Anticancer Res 巻: 4 ページ: 1175-1180
  • 査読あり
• [雑誌論文] Major liver resection stimulates atromal recruitment and metastasis compared with repeated minor resection. (2012)
  • 著者名/発表者名: Momiyama M
  • 雑誌名: J Surg Res 巻: 178 号: 1 ページ: 280-287
  • DOI: 10.1016/j.jss.2012.03.020
  • 査読あり
• [雑誌論文] Multi-color pallet of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. (2012)
  • 著者名/発表者名: Suetsugu A
  • 雑誌名: J Cell Biochem 巻: 7 号: 7 ページ: 2290-2295
  • DOI: 10.1002/jcb.24099
  • 査読あり
• [雑誌論文] Inhibition of metastasis of circulating human prostate cancer cells in the chick embryo by an extracellular matrix produced by foreskin fibroblasts in culture. (2012)
  • 著者名/発表者名: Menen R
  • 雑誌名: Anticancer Res 巻: 5 ページ: 1573-1577
  • 査読あり
• [雑誌論文] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice. (2012)
  • 著者名/発表者名: Zhang Y
  • 雑誌名: Anticancer Res 巻: 7 ページ: 2501-2508
  • 査読あり
• [雑誌論文] Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu. (2012)
  • 著者名/発表者名: Hu M
  • 雑誌名: Anticancer Res 巻: 7 ページ: 2509-2514
  • 査読あり
• [雑誌論文] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer. (2012)
  • 著者名/発表者名: Menen RS
  • 雑誌名: In Vivo 巻: 26 ページ: 565-569
  • 査読あり
• [雑誌論文] Non-invasive Fluorescent-protein Imaging of Orthotopic Pancreatic-cancer-patient Tumorgraft Progression in Nude Mice. (2012)
  • 著者名/発表者名: Suetsugu A
  • 雑誌名: Anticancer Res 巻: 8 ページ: 3063-3067
  • 査読あり
• [雑誌論文] Fluorescent proteins enhance UVC PDT of cancer cells. (2012)
  • 著者名/発表者名: Momiyama M
  • 雑誌名: Anticancer Res 巻: 10 ページ: 4327-4330
  • 査読あり
• [学会発表] HIV感染治療開始後に伴うB型肝炎の免疫再構築症候群の検討末次淳 (2013)
  • 著者名/発表者名: 宮崎恒起、華井竜徳、今井健二、白木亮、高井光治、清水雅仁、内木隆文、鶴見寿、森脇久隆
  • 学会等名: JDDW
  • 発表場所: 東京
  • 年月日: 2013-10-10
• [学会発表] 当院におけるC型慢性肝炎に対する3剤併用療法の初期治療効果と副作用の検討末次淳 (2013)
  • 著者名/発表者名: 宮崎恒起、華井竜徳、今井健二、白木亮、高井光治、大澤陽介、清水雅仁、内木隆文、森脇久隆
  • 学会等名: JDDW
  • 発表場所: 東京
  • 年月日: 2013-10-09
• [学会発表] Comparison of Salmonella typhimurium A1-R and chemotherapy of human-patient pancreatic tumorgrafts (2013)
  • 著者名/発表者名: Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Hassanein MK, Suetsugu A, Chishima T, Kuniya Tanaka, Micheal Bouvet, Endo I, Hoffman RM
  • 学会等名: 第72回日本癌学会学術総会
  • 発表場所: 東京
  • 年月日: 2013-10-05
• [学会発表] Cell cycle position and chemoresponse depends on location in tumor (2013)
  • 著者名/発表者名: Tome Y, Michelle A. Digman, Momiyama M, Suetsugu A, Enrico Gratton, Yano S, Hoffman RM
  • 学会等名: 第72回日本癌学会学術総会
  • 発表場所: 東京
  • 年月日: 2013-10-03
• [学会発表] C型慢性肝炎IFN治療SVR後の発癌症例の検討末次淳 (2013)
  • 著者名/発表者名: 内木隆文、森脇久隆
  • 学会等名: 第40回日本肝臓学会西部会 シンポジウム
• [学会発表] Salmonella typhimurium A1-R targets chemoresistant stem-like human pancreatic cancer cells (2013)
  • 著者名/発表者名: Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Hassanein MK, Suetsugu A, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM
  • 学会等名: American Society of Clinical Oncology (ASCO)
  • 発表場所: Chicago, Illinois
• [学会発表] Salmonella typhimurium A1-R effectively targets human-patient pancreatic tumorgrafts in nude mice (2013)
  • 著者名/発表者名: Zhao M, Katz MH, Fleming J, Suetsugu A, Zhang Y, Ali Maawy, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM, Hiroshima Y
  • 学会等名: American Society of Clinical Oncology (ASCO)
  • 発表場所: Chicago, Illinois
• [学会発表] CHARACTERIZATION AND IMAGING OF CD133+ LIVER CANCER STEM CELLS (2013)
  • 著者名/発表者名: Suetsugu A, Y. Osawa, H. Aoki, T. Kunisada, H. Tsurumi,R.M. Hoffman, H. Moriwaki
  • 学会等名: European Association for the Study of the Liver (EASL)
  • 発表場所: Amsterdam (The Netherlands)
• [学会発表] ACID SPHINGOMYELINASE INHIBITS GROWTH OF METASTATIC LIVER TUMOR (2013)
  • 著者名/発表者名: Y. Osawa, A. Suetsugu, H. Moriwaki, O. Kozawa
  • 学会等名: European Association for the Study of the Liver (EASL)
  • 発表場所: Amsterdam (The Netherlands)
• [学会発表] Efficacy of Salmonella typhimurium A1-R on chemoresistant stem-like human pancreatic cancer cells (2013)
  • 著者名/発表者名: Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Mohamed Hassanein, Suetsugu A, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC
• [学会発表] Cancer cell location in tumor determines cell cycle position and dormancy (2013)
  • 著者名/発表者名: Yano S, Tome Y, Michelle Digman, Momiyama M, Suetsugu A, Enrico Gratton, Hoffman RM
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC
• [学会発表] Imaging of methioninase-induced S/G_2-phase-trapping for subsequent effective chemotherapy (2013)
  • 著者名/発表者名: Yano S, Tome Y, Michelle Digman, Momiyama M, Suetsugu A, Enrico Gratton, Hoffman RM
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC
• [学会発表] Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts (2013)
  • 著者名/発表者名: Zhao M, Katz MH, Fleming J, Suetsugu A, Zhang Y, Ali Maawy, Chishima T, Kuniya Tanaka, Bouvet M, Hiroshima Y, Endo I, Hoffman RM
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC
• [学会発表] Imaging exosome transfer from colon cancer cells to stroma at liver metastatic sites in nude mouse (2013)
  • 著者名/発表者名: Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. Hoffman RM
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC
• [学会発表] Efficacy of Salmonella typhimurium A1-R on chemoresistant stem-like human pancreatic cancer cells (2013)
  • 著者名/発表者名: Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman.
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC, （アメリカ）
• [学会発表] Cancer cell location in tumor determines cell cycle position and dormancy (2013)
  • 著者名/発表者名: Shuya Yano, Yasunori Tome, Michelle Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Robert M. Hoffman.
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC, （アメリカ）
• [学会発表] Imaging of methioninase-induced S/G2-phase-trapping for subsequent effective chemotherapy (2013)
  • 著者名/発表者名: Shuya Yano, Yasunori Tome, Michelle Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Robert M. Hoffman.
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC, （アメリカ）
• [学会発表] Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts (2013)
  • 著者名/発表者名: Ming Zhao, Matthew H.G. Katz, Jason B. Fleming, Atsushi Suetsugu, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Yukihiko Hiroshima, Itaru Endo, Robert M. Hoffman.
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC, （アメリカ）
• [学会発表] Imaging exosome transfer from colon cancer cells to stroma at liver metastatic sites in nude mouse (2013)
  • 著者名/発表者名: Atsushi Suetsugu, Kimi Homma, Shigetoyo Saji, Hisataka Moriwaki, Takahiro Ochiya, Robert M. Hoffman.
  • 学会等名: AACR annual meeting 2013
  • 発表場所: Washington DC, （アメリカ）
• [学会発表] CHARACTERIZATION AND IMAGING OF CD133+ LIVER CANCER STEM CELLS (2013)
  • 著者名/発表者名: A. Suetsugu, Y. Osawa, H. Aoki, T. Kunisada, H. Tsurumi,R.M. Hoffman, H. Moriwaki
  • 学会等名: European Association for the Study of the Liver (EASL)
  • 発表場所: Amsterdam, （オランダ）
• [学会発表] ACID SPHINGOMYELINASE INHIBITS GROWTH OF METASTATIC LIVER TUMOR (2013)
  • 著者名/発表者名: Y. Osawa, A. Suetsugu, H. Moriwaki, O. Kozawa
  • 学会等名: European Association for the Study of the Liver (EASL)
  • 発表場所: Amsterdam, （オランダ）
• [学会発表] Salmonella typhimurium A1-R targets chemoresistant stem-like human pancreatic cancer cells. (2013)
  • 著者名/発表者名: Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed K. Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
  • 学会等名: American Society of Clinical Oncology (ASCO)
  • 発表場所: Chicago, （アメリカ）
• [学会発表] Salmonella typhimurium A1-R effectively targets human-patient pancreatic tumorgrafts in nude mice. (2013)
  • 著者名/発表者名: Ming Zhao, Matthew H. G. Katz, Jason B. Fleming, Atsushi Suetsugu, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman, Yukihiko Hiroshima
  • 学会等名: American Society of Clinical Oncology (ASCO)
  • 発表場所: Chicago, （アメリカ）
• [学会発表] シンポジウム C型慢性肝炎IFN治療SVR後の発癌症例の検討 (2013)
  • 著者名/発表者名: 末次 淳、内木隆文、森脇久隆
  • 学会等名: 第40回日本肝臓学会西部会
  • 発表場所: 岐阜
• [学会発表] Highly-effective resection of orthotopic human glioma by fluorescence-guided surgry in nude mice (2012)
  • 著者名/発表者名: Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Micheal Bouvet, Chishima T, Endo I, Hoffman RM
  • 学会等名: 第71回日本癌学会学術総会
  • 発表場所: 札幌
  • 年月日: 2012-09-21
• [学会発表] Treatment of brain tumors in nude mice with intra-cranial UV irradiation (2012)
  • 著者名/発表者名: Satoshi Hasegawa, Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Chishima T, Micheal Bouvet, Hoffman RM
  • 学会等名: 第71回日本癌学会学術総会
  • 発表場所: 札幌
  • 年月日: 2012-09-21
• [学会発表] Role of stellate cells during liver metastasis of pancreatic cancer in nude mice Cynthia Snyder (2012)
  • 著者名/発表者名: Suetsugu A, Moriwaki H, Saji S, Micheal Bouvet, Hoffman RM
  • 学会等名: 第71回日本癌学会学術総会
  • 発表場所: 札幌
  • 年月日: 2012-09-20
• [学会発表] Paxillin-expressing breast cancer imaged by raster-image-correlation spectroscopy of GFP in vivo and in vitro (2012)
  • 著者名/発表者名: Suetsugu A, Michelle Digman, Federica Sabatini, Moriwaki H, Saji S, Micheal Bouvet, Enrico Grattion, Hoffman RM
  • 学会等名: 第71回日本癌学会学術総会
  • 発表場所: 札幌
  • 年月日: 2012-09-19
• [学会発表] Use of fluorescent protein labeling of storoma to image orthotopic pancreatic patient tumors in nude mice (2012)
  • 著者名/発表者名: Hoffman RM, Suetsugu A, Matthew H Katz, Fleming J, Mark Truty, Ryan Thomas, Hassanein MK, Moriwaki H, Micheal Bouvet, Saji S
  • 学会等名: 第71回日本癌学会学術総会
  • 発表場所: 札幌
  • 年月日: 2012-09-19
• [学会発表] Trafficking of exosomes imaged in vivo with GFP (2012)
  • 著者名/発表者名: Ochiya T, Kimi Honma, Suetsugu A
  • 学会等名: 第71回日本癌学会学術総会
  • 発表場所: 札幌
  • 年月日: 2012-09-19
• [学会発表] Making patient tumors glow in nude mice by coloring the stroma with fluorescent proteins (2012)
  • 著者名/発表者名: Suetsugu A, Katz MH, Fleming J, Mark Truty, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • 学会等名: 第10回日本臨床腫瘍学会
  • 発表場所: 大阪
  • 年月日: 2012-07-27
• [学会発表] RFP-expressing glioma successfully resected in othotopic mouse models using fluorescence-guided surgery (2012)
  • 著者名/発表者名: Momiyama M, Suetsugu A, Kishimoto H, Chishima T, Bouvet M, Endo I
  • 学会等名: World Molecular imaging congress (WMIC) 2012
  • 発表場所: Dublin
• [学会発表] Multi-color imaging model of the tumor environment (2012)
  • 著者名/発表者名: Suetsugu A, Katz MH, Fleming J, Hassanein MK, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • 学会等名: 第21回日本がん転移学会学術集会・総会
  • 発表場所: 金沢
• [学会発表] Salmonella typhimurim can eradicate human glioma in a nude mouse orthotopic model (2012)
  • 著者名/発表者名: Momiyama M, Zhao M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Micheal Bouvet, Chishima T, Endo I, Hoffman RM
  • 学会等名: 第21回日本がん転移学会学術集会・総会
  • 発表場所: 金沢
• [学会発表] Effect of major liver resection on colon cancer metastasis in the lung and liver (2012)
  • 著者名/発表者名: Hoffman RM, Momiyama M, Suetsugu A, Kishimoto H, Chishima T, Bouvet M, Endo I
  • 学会等名: American Society of Clinical Oncology (ASCO) 2012
  • 発表場所: Chicago
• [学会発表] Determining the metastatic potential of circulating tumor cells (2012)
  • 著者名/発表者名: Menen RS, Emmett Pinney, Katarina Kolostova, Vladimir Bobek, Suetsugu A, Nan Zhang, Hoffman RM
  • 学会等名: American Society of Clinical Oncology (ASCO) 2012
  • 発表場所: Chicago
• [学会発表] L-tryptophan-mediated enhancement of susceptibility to NAFLD is dependent on the mTOR (2012)
  • 著者名/発表者名: Yosuke Osawa, Yoichi Yasuda, Suetsugu A, Moriwaki H, Osamu Kozawa
  • 学会等名: Asian pacific Digestive Week 2012
  • 発表場所: Bangkok,Thailand
• [学会発表] Potential use of CD133-positive bone marrow cells in the treatment of liver fibrosis (2012)
  • 著者名/発表者名: Suetsugu A, Yosuke Osawa, Hitomi Aoki, Takahiro Kunisada, Ogata H, Hisashi Tsurumi, Hoffman RM, Moriwaki H
  • 学会等名: Asian pacific Digestive Week 2012
  • 発表場所: Bangkok,Thailand
• [学会発表] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice (2012)
  • 著者名/発表者名: Zhang Y, Suetsugu A, Nan Zhang, Lei Zhang, Hoffman RM, Zhao M
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] In vivo tracking of cancer-cell-derived exosomes (2012)
  • 著者名/発表者名: Honma K, Suetsugu A, Ochiya T, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Multicolor imageable orthotopic tumorgraft models of human patient pancreatic cancer (2012)
  • 著者名/発表者名: Suetsugu A, Katz MH, Fleming J, Hassanein MK, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Imaging stromal recruitment during liver metastasis formation in the GFP-MUP-uPA mouse (2012)
  • 著者名/発表者名: Suetsugu A, Ogata H, Moriwaki H, Saji S, Karin M, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer (2012)
  • 著者名/発表者名: Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Abdool R. Moossa, Bouvet M, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Imaging sub-cellular dynamics of proliferating intra- and extra-vascular cancer cells (2012)
  • 著者名/発表者名: Suetsugu A, Michelle Digman, Jose A. Aguilar, Ping Jiang, Mohamed Hassanein, Moriwaki H, Bouvet M, Saji S, Enrico Gratton, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Imaging cell cycle progression in gastric cancer lymph node metastasis indicates large fraction of proliferating cancer cells (2012)
  • 著者名/発表者名: Suetsugu A, Mohamed Hassanein, Moriwaki H, Yano S, Toshiyoshi Fujiwara, Bouvet M, Saji S, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Color-coded imaging of the pre-metastatic niche in the lung and liver indicates the involvement of cancer-associated fibroblasts (2012)
  • 著者名/発表者名: Suetsugu A, Momiyama M, Yosuke Osawa, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Raster-image-correlation spectroscopy of paxillin-GFP-expressing breast cancer cell in vitro and in vivo (2012)
  • 著者名/発表者名: Suetsugu A, Michelle Digman, Federica Sabatini, Moriwaki H, Saji S, Enrico Gratton, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Imaging of the interaction of pancreatic cancer and stellate cells during liver metastasis (2012)
  • 著者名/発表者名: Suetsugu A, Cynthia Snyder, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Real-time imaging of inter-cellular communication via exosomes (2012)
  • 著者名/発表者名: Honma K, Suetsugu A, Ochiya T, Hoffman RM
  • 学会等名: AACR annual meeting 2012
  • 発表場所: Chicago
• [学会発表] Fluorescence lifetime imaging microcopy of extravasating cancer cells in the mouse microenvironment (2012)
  • 著者名/発表者名: Michelle A. Digman, Suetsugu A, Federica Sabatini, Hoffman RM, Enrico Gratton
  • 学会等名: 56th Annual Meeting of the Biophysical Society
  • 発表場所: San Diego, California
• [学会発表] RFP-expressing glioma successfully resected in othotopic mouse models using fluorescence-guided surgery. (2012)
  • 著者名/発表者名: Masashi Momiyama
  • 学会等名: World Molecular imaging congress (WMIC)
  • 発表場所: Dublin, Ireland
• [学会発表] Non-invasive imaging of orthotopic patient pancreatic tumors in nude mice using fluorescent proteins. (2012)
  • 著者名/発表者名: Atsushi Suetsugu
  • 学会等名: World Molecular imaging congress (WMIC)
  • 発表場所: Dublin, Ireland
• [学会発表] In vivo imaging of human pancreatic cancer liver metastasis in orthotopic nude mouse models indicates the importance of pancreatic stellate cells. (2012)
  • 著者名/発表者名: Atsushi Suetsugu
  • 学会等名: World Molecular imaging congress (WMIC)
  • 発表場所: Dublin, Ireland
• [学会発表] Cell cycle position and chemoresponse depends on location in tumor
  • 著者名/発表者名: Yasunori Tome, Michelle A. Digman, Masashi Momiyama, Atsushi Suetsugu, Enrico Gratton, Shuya Yano, Robert M. Hoffman
  • 学会等名: 第72回日本癌学会学術総会
  • 発表場所: 東京
• [学会発表] Comparison of Salmonella typhimurium A1-R and chemotherapy of human-patient pancreatic tumorgrafts
  • 著者名/発表者名: Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed K. Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Micheal Bouvet, Itaru Endo, Robert M. Hoffman
  • 学会等名: 第72回日本癌学会学術総会
  • 発表場所: 東京
• [学会発表] 当院におけるC型慢性肝炎に対する3剤併用療法の初期治療効果と副作用の検討
  • 著者名/発表者名: 末次 淳、宮崎恒起、華井竜徳、今井健二、白木 亮、高井光治、大澤陽介、清水雅仁、内木隆文、森脇久隆
  • 学会等名: JDDW2013
  • 発表場所: 東京
• [学会発表] HIV感染治療開始後に伴うB型肝炎の免疫再構築症候群の検討
  • 著者名/発表者名: 末次 淳、宮崎恒起、華井竜徳、今井健二、白木 亮、高井光治、清水雅仁、内木隆文、鶴見寿、森脇久隆
  • 学会等名: JDDW2013
  • 発表場所: 東京
• [学会発表] Paxillin-expressing breast cancer imaged by raster-image-correlation spectroscopy of GFP in vivo and in vitro
  • 著者名/発表者名: Atsushi Suetsugu
  • 学会等名: 第71回日本癌学会学術総会
  • 発表場所: ロイトン札幌（札幌）
• [学会発表] シンポジウム 肝組織幹細胞および肝癌幹細胞における表面マーカーCD133の意義
  • 著者名/発表者名: 末次 淳
  • 学会等名: 第99回日本消化器病学会総会
  • 発表場所: 城山観光ホテル（鹿児島市）