| 配分額 *注記 |
18,590千円 (直接経費: 14,300千円、間接経費: 4,290千円)
2026年度: 5,200千円 (直接経費: 4,000千円、間接経費: 1,200千円)
2025年度: 5,460千円 (直接経費: 4,200千円、間接経費: 1,260千円)
2024年度: 7,930千円 (直接経費: 6,100千円、間接経費: 1,830千円)
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| 研究開始時の研究の概要 |
We plan to explain the currently unknown dependence of SPO-11, the enzyme that cuts DNA to initiate recombination in meiosis, on DSB-1, a conserved cofactor whose regulation by phosphorylation controls the number of double-strand breaks. We will use biochemistry to determine points of contact between DSB-1 and SPO-11, and high-resolution live microscopy imaging to see where DSB-1 localizes under conditions when it cannot be phosphorylated to turn down its activity. These complementary approaches will present new information about a key protein enabling genetic inheritance through meiosis.
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