Development of new therapeutic drugs for drug addiction targeting potassium channels

• 研究課題/領域番号: 24K18291
• 研究種目: 若手研究
• 配分区分: 基金
• 審査区分: 小区分47040:薬理学関連
• 研究機関: 藤田医科大学
• 研究代表者: 張 心健 藤田医科大学, 精神・神経病態解明センター, 助教 (10850430)
• 研究期間 (年度): 2024-04-01 – 2026-03-31
• 研究課題ステータス: 交付 (2024年度)
• 配分額: 4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円); 2025年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円); 2024年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
• キーワード: drug addiction / potassium channels / nucleus accumbens / medium spiny neurons / neuronal excitability

研究開始時の研究の概要

Although drug addiction is a serious social problem, there is no effective solution, yet. Previously, we have analyzed intracellular dopamine signaling pathways in NAc and elucidated that dopamine increases neuronal excitability by targeting potassium channels to regulate rewarding behavior. In this study, I will manipulate the activity of potassium channel to examine its effect on addictive drug-associated memory. I will also elucidate the mechanism between potassium channel and reward memory, and screen useful potassium channel openers that may become potential therapy for drug addiction.