| 配分額 *注記 |
4,680千円 (直接経費: 3,600千円、間接経費: 1,080千円)
2025年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
2024年度: 2,340千円 (直接経費: 1,800千円、間接経費: 540千円)
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| 研究開始時の研究の概要 |
Few studies have investigated how DEL-1 promotes bone growth and inhibits pro-resorptive activities. Established molecular biology and cell imaging, techniques will be used to show 1) how DEL-1 modulates intracellular Ca2+ signaling, 2) determine if DEL-1 induces EV formation by modulating intracellular Ca2+ signaling in osteoclasts and osteoblasts, and 3) if/how specific EV subpopulations from DEL-1 stimulated cells to promote calcification and bone growth.
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