| 研究課題/領域番号 |
24K23047
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| 研究種目 |
研究活動スタート支援
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| 配分区分 | 基金 |
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| 審査区分 |
0403:人間医工学およびその関連分野
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| 研究機関 | 東京大学 |
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研究代表者 |
LI RUICHEN 東京大学, ニューロインテリジェンス国際研究機構, 特任研究員 (71001070)
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| 研究期間 (年度) |
2024-07-31 – 2026-03-31
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| 研究課題ステータス |
交付 (2024年度)
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| 配分額 *注記 |
2,600千円 (直接経費: 2,000千円、間接経費: 600千円)
2025年度: 1,040千円 (直接経費: 800千円、間接経費: 240千円)
2024年度: 1,560千円 (直接経費: 1,200千円、間接経費: 360千円)
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| キーワード | Multi-system Model / Autonomic Nervous System / Heart Rate / Blood Pressure / Neurodiversity / Interoception / Multi-system modeling / Autonomic nervous system / Emotional states |
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| 研究開始時の研究の概要 |
This project will provide a computational modeling method by integrating cardiovascular, respiratory, and autonomic nervous systems. The multi-system model will be established to reproduce and predict the interoceptive signals representing mental performances, such as blood pressure and heart rate variability, and further investigate the interaction mechanisms between them and emotional fluctuations.
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| 研究実績の概要 |
I developed a computational model that integrates the cardiovascular, respiratory, and autonomic nervous systems to simulate how heart rate and blood pressure are regulated. This model was used to compare individuals with typical development and those with different conditions of neurodiversity, such as autism spectrum disorder.
By fitting the model to existing physiological data, I identified differences in how the autonomic nervous system functions in these groups under specific tests, such as posture change and breathing tasks. The results suggest that individuals with autism may show increased sensitivity to nervous system signals and may benefit from breathing-based support.
In the next stage, I will apply this model to analyze more detailed individual differences.
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| 現在までの達成度 |
現在までの達成度
1: 当初の計画以上に進展している
理由
In line with the original plan, I developed a multi-system computational model to simulate how the autonomic nervous system (ANS) regulates heart rate and blood pressure under both typical developmental (TD) and neurodivergent conditions, such as autism spectrum disorder (ASD).
The model construction was completed more smoothly than expected, and promising results were obtained in investigating autonomic control modes on interoceptive responses and simulating these responses based on sympathetic-parasympathetic balance during various autonomic function tests.
I have presented the findings at three international conferences. A journal paper and another conference presentation are currently in preparation.
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| 今後の研究の推進方策 |
In the next stage, I will apply the model to analyze individual differences more precisely, focusing on how different autonomic control patterns affect heart rate (HR) and blood pressure (BP) responses. Published HR and BP data will be used for model fitting and validation. Specifically, I will map reported data onto simulation surfaces defined by sympathetic and parasympathetic activity under various autonomic tests in both autism and control groups. I will also incorporate respiratory inputs with varying rates and amplitudes to explore their effects on restoring HR and BP responses under dysfunctional ANS regulation. A journal paper and a new conference presentation are currently in preparation.
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