| 研究開始時の研究の概要 |
Synaptic plasticity, crucial for memory and other brain functions, involves synaptic proteins with unclear regulation. We propose that synaptic protein condensates formed via liquid-liquid phase separation (LLPS) are key to synaptic plasticity.
This study aims to explore memory mechanisms through LLPS in vivo. By using photoactivatable proteins, we will manipulate LLPS in living cultures and observe neuron network changes with light stimulation.
The findings could uncover mechanisms of memory formation and extinction, potentially leading to therapies for disorders like dementia and PTSD.
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