公募研究
新学術領域研究(研究領域提案型)
In the last fiscal year we examined how locus coeruleus noradrenaline neurons in the brainstem encode information when animals are learning to fear a sensory stimulus and when the animals realizes that the sensory stimulus is no longer threatening and reduce their fear responses (a process termed fear extinction). We found that some LC-noradrenaline neurons increased their firing rate in high fear states while others increased their response when animals realized they should no longer be afraid during extinction. In addition we found that LC-noradrenaline synaptic inputs to the amygdala are important for fear learning while synaptic innervation of the medial prefrontal cortex is important for extinction. Together with our previous results this showed that different populations of LC-noradrenaline neurons control fear and extinction learning.
29年度が最終年度であるため、記入しない。
すべて 2018 2017 2016
すべて 雑誌論文 (7件) (うち国際共著 7件、 査読あり 7件、 オープンアクセス 4件、 謝辞記載あり 2件) 学会発表 (4件) (うち国際学会 2件、 招待講演 4件)
Nature Communications
巻: In press
Current Opinion in Neurobiology
巻: 49 ページ: 148-157
10.1016/j.conb.2018.02.010
巻: 48 ページ: 37-44
10.1016/j.conb.2017.09.006
Nature Neuroscience
巻: 20 号: 11 ページ: 1602-1611
10.1038/nn.4642
巻: 20(1) 号: 1 ページ: 90-97
10.1038/nn.4439
Neuropsychopharmacology
巻: 42(4) 号: 4 ページ: 895-903
10.1038/npp.2016.238
巻: In press 号: 7 ページ: 965-972
10.1038/nn.4308
