| 配分額 *注記 |
6,240千円 (直接経費: 4,800千円、間接経費: 1,440千円)
2017年度: 3,120千円 (直接経費: 2,400千円、間接経費: 720千円)
2016年度: 3,120千円 (直接経費: 2,400千円、間接経費: 720千円)
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| 研究実績の概要 |
Whereas hibernation is common in rodents and other animals, there are only a very few cases of suspected hibernation or states similar to hibernation in humans. Induced hibernation, also known as suspended animation, is the slowing or stopping of life processes without termination by cooling the body down. This technology has great potential for long distance space travel and medicine. Induced hypothermia has been used for open-heart surgeries and other clinical procedures, but the risk for brain functions is largely unknown. We elucidated the effects of chemogenetically induced hypothermia on the consolidation of fear memory. Therefore, we developed a telemetric system to measure sleep and body temperature. Moreover, we used an innovative genetically engineered system to induce hypothermia by activating GABAergic neurons in the median preoptic area of the hypothalamus. The induced hypothermia resulted in reduced learning and expression of fear.
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