| 研究領域 | マルチスケール精神病態の構成的理解 |
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| 研究課題/領域番号 |
19H05234
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| 研究種目 |
新学術領域研究(研究領域提案型)
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| 配分区分 | 補助金 |
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| 審査区分 |
生物系
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
JOHANSEN JOSHUA 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (80625351)
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| 研究期間 (年度) |
2019-04-01 – 2021-03-31
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| 研究課題ステータス |
完了 (2020年度)
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| 配分額 *注記 |
7,800千円 (直接経費: 6,000千円、間接経費: 1,800千円)
2020年度: 3,900千円 (直接経費: 3,000千円、間接経費: 900千円)
2019年度: 3,900千円 (直接経費: 3,000千円、間接経費: 900千円)
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| キーワード | Noradrenaline / Emotion / PTSD / Amygdala / medial prefrontal cortex / Learning & Memory / Locus Coeruleus / Prefrontal Cortex / Fear Extinction / Anxiety / prefrontal cortex / locus coeruleus / neuromodulation / emotion / anxiety disorder / stress |
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| 研究開始時の研究の概要 |
We will study the neural mechanisms for how emotional fear responses are controlled when they are innapropriate and how this control is dysregulated in conditions such as post-traumatic stress and anxiety disorders. Specifically we will examine how the brain noradrenaline system is regulated by the medial prefrontal cortex, a brain region important in cognition and emotional control.
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| 研究実績の概要 |
Controlling and extinguishing memories of traumatic experiences is critical in the treatment of post-traumatic stress disorder and certain anxiety disorders. Dysregulation of the noradrenaline system occurs in PTSD and anxiety disorder patients, but the underlying mechanisms for this are unclear. In previous research related to this grant we showed that the locus coeruleus (LC), the major source of noradrenaline to the forebrain, contains distinct cell populations that project to the amygdala or medial prefrontal cortex (mPFC). In the last year we've established a retrograde monosynaptic rabies tracing approach in mice and rats to map the brainwide afferent inputs to these cell populations. We've found that both cell populations receive some common inputs, but certain connections are specific. Notably, amygdala projecting LC neurons preferentially receive recurrent inputs from the amygdala while mPFC projecting LC neurons preferentially receive afferents from the mPFC. This shows that recurrent connectivity is an important organizational feature of this modularly organized neuromodulatory system and provides a circuit mechanism for their unique response properties and functionality related to emotional learning and memory. We are now finalizing analysis of how stress alters this connectivity.
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| 現在までの達成度 (段落) |
令和2年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
令和2年度が最終年度であるため、記入しない。
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